In the future electronics,all device components will be connected wirelessly to displays that serve as information input and/or output ports.There is a growing demand of flexible and wearable displays,therefore,for in...In the future electronics,all device components will be connected wirelessly to displays that serve as information input and/or output ports.There is a growing demand of flexible and wearable displays,therefore,for information input/output of the nextgeneration consumer electronics.Among many kinds of light-emitting devices for these next-generation displays,quantum dot light-emitting diodes(QLEDs)exhibit unique advantages,such as wide color gamut,high color purity,high brightness with low turn-on voltage,and ultrathin form factor.Here,we review the recent progress on flexible QLEDs for the next-generation displays.First,the recent technological advances in device structure engineering,quantum-dot synthesis,and high-resolution full-color patterning are summarized.Then,the various device applications based on cutting-edge quantum dot technologies are described,including flexible white QLEDs,wearable QLEDs,and flexible transparent QLEDs.Finally,we showcase the integration of flexible QLEDs with wearable sensors,micro-controllers,and wireless communication units for the next-generation wearable electronics.展开更多
Intracerebral hemorrhage （ICH） is a devastating subtype of stroke with a high mortality rate, for which there currently is no effective treatment. A perihematomal edema caused by an intense inflammatory reaction is ...Intracerebral hemorrhage （ICH） is a devastating subtype of stroke with a high mortality rate, for which there currently is no effective treatment. A perihematomal edema caused by an intense inflammatory reaction is more deleterious than the hematoma itself and can result in neurological deterioration and death. Ceria nanoparticles （CeNPs） are potent free radical scavengers with potential for biomedical applications. As oxidative stress plays a major role in post-ICH inflammation, we hypothesized that CeNPs might protect against ICH. To test this hypothesis, core CeNPs were synthesized using a modified reverse micelle method and covered with phospholipid-polyethylene glycol （PEG） to achieve biocompatibility. We investigated whether our custom-made biocompatible CeNPs have protective effects against ICH. The CeNPs reduced oxidative stress, hemin-induced cytotoxicity, and inflammation in vitro. In a rodent ICH model, intravenously administered CeNPs were mainly distributed in the hemorrhagic hemisphere, suggesting that they could diffuse through the damaged blood-brain barrier. Moreover, CeNPs attenuated microglia/macrophage recruitment around the hemorrhagic lesion and inflammatory protein expression. Finally, CeNP treatment reduced the brain edema by 68.4% as compared to the control. These results reveal the great potential of CeNPs as a novel therapeutic agent for patients with ICH.展开更多
基金This research was supported by IBS-R006-D1 and IBS-R006-A1.
文摘In the future electronics,all device components will be connected wirelessly to displays that serve as information input and/or output ports.There is a growing demand of flexible and wearable displays,therefore,for information input/output of the nextgeneration consumer electronics.Among many kinds of light-emitting devices for these next-generation displays,quantum dot light-emitting diodes(QLEDs)exhibit unique advantages,such as wide color gamut,high color purity,high brightness with low turn-on voltage,and ultrathin form factor.Here,we review the recent progress on flexible QLEDs for the next-generation displays.First,the recent technological advances in device structure engineering,quantum-dot synthesis,and high-resolution full-color patterning are summarized.Then,the various device applications based on cutting-edge quantum dot technologies are described,including flexible white QLEDs,wearable QLEDs,and flexible transparent QLEDs.Finally,we showcase the integration of flexible QLEDs with wearable sensors,micro-controllers,and wireless communication units for the next-generation wearable electronics.
文摘Intracerebral hemorrhage （ICH） is a devastating subtype of stroke with a high mortality rate, for which there currently is no effective treatment. A perihematomal edema caused by an intense inflammatory reaction is more deleterious than the hematoma itself and can result in neurological deterioration and death. Ceria nanoparticles （CeNPs） are potent free radical scavengers with potential for biomedical applications. As oxidative stress plays a major role in post-ICH inflammation, we hypothesized that CeNPs might protect against ICH. To test this hypothesis, core CeNPs were synthesized using a modified reverse micelle method and covered with phospholipid-polyethylene glycol （PEG） to achieve biocompatibility. We investigated whether our custom-made biocompatible CeNPs have protective effects against ICH. The CeNPs reduced oxidative stress, hemin-induced cytotoxicity, and inflammation in vitro. In a rodent ICH model, intravenously administered CeNPs were mainly distributed in the hemorrhagic hemisphere, suggesting that they could diffuse through the damaged blood-brain barrier. Moreover, CeNPs attenuated microglia/macrophage recruitment around the hemorrhagic lesion and inflammatory protein expression. Finally, CeNP treatment reduced the brain edema by 68.4% as compared to the control. These results reveal the great potential of CeNPs as a novel therapeutic agent for patients with ICH.
