Aim:A“seed”of lung cancer metastasis is circulating tumor cells(CTCs),which may be dislodged from a tumor during biopsy.This possibility was assessed among patients who underwent lung tumor biopsy using flexible fib...Aim:A“seed”of lung cancer metastasis is circulating tumor cells(CTCs),which may be dislodged from a tumor during biopsy.This possibility was assessed among patients who underwent lung tumor biopsy using flexible fiber-topic bronchoscopy(FFB).Methods:The study involved six patients with non-small cell lung cancer who underwent FFB biopsy to diagnose a lesion pathologically(5 males and 1 female,median age 63 years,6 adenocarcinomas,of 4 clinical-stage IA,1 stage IB,and 1 stage IIIA),CTCs were extracted from the peripheral vein blood at pre-FFB and at post-FFB using a size selection method.Results:No t umor c ell was d etected a t p re-a nd p ost-FFB was i n t hree c ases(50%);no tumor cells were detected pre-FFB while CTCs were detected at post-FFB in two cases(33.3%);and CTCs were detected at pre-FFB with numerous CTCs detected at post-FFB in one case(17.7%).In addition,similar tendencies were observed in each analysis of single-cell and clustered-cell categories.Conclusion:These results suggest that a FFB biopsy of lung cancer may potentially dislodge CTCs from a tumor into the circulating peripheral blood.展开更多
基金supported by a Grant-in-Aid for Scientific Research[(B)25293301]from the Japan Ministry of Education,Science,Sports and Culture.
文摘Aim:A“seed”of lung cancer metastasis is circulating tumor cells(CTCs),which may be dislodged from a tumor during biopsy.This possibility was assessed among patients who underwent lung tumor biopsy using flexible fiber-topic bronchoscopy(FFB).Methods:The study involved six patients with non-small cell lung cancer who underwent FFB biopsy to diagnose a lesion pathologically(5 males and 1 female,median age 63 years,6 adenocarcinomas,of 4 clinical-stage IA,1 stage IB,and 1 stage IIIA),CTCs were extracted from the peripheral vein blood at pre-FFB and at post-FFB using a size selection method.Results:No t umor c ell was d etected a t p re-a nd p ost-FFB was i n t hree c ases(50%);no tumor cells were detected pre-FFB while CTCs were detected at post-FFB in two cases(33.3%);and CTCs were detected at pre-FFB with numerous CTCs detected at post-FFB in one case(17.7%).In addition,similar tendencies were observed in each analysis of single-cell and clustered-cell categories.Conclusion:These results suggest that a FFB biopsy of lung cancer may potentially dislodge CTCs from a tumor into the circulating peripheral blood.
