Alzheimer’s disease(AD)is the most common cause of dementia.Although AD was initially considered to be a cell autonomous neurodegenerative disorder,marked neuroinflammation has been observed in brains of AD patients....Alzheimer’s disease(AD)is the most common cause of dementia.Although AD was initially considered to be a cell autonomous neurodegenerative disorder,marked neuroinflammation has been observed in brains of AD patients.Genetic and molecular biological findings have suggested the central nervous system(CNS)inflammatory processes to be involved in the etiopathogenesis of AD,in which the activated microglia play a key role.展开更多
基金mainly supported in part by a grant from the Japan Agency for Medical Research and Developm ent(AMED)(to T.T.)partially by Grants-in-Aid(Nos.15 K09319 and 18 K07506 to T.K.,No.20 K16605 to T.O.,No.18K15461 to H.T.)from the Ministry of Education,Culture,Sports,Science and Technology of Japanresearch grants from Dainippon Sumitomo Pharma in 2018(to T.O.)and 2017(to T.K.).
文摘Alzheimer’s disease(AD)is the most common cause of dementia.Although AD was initially considered to be a cell autonomous neurodegenerative disorder,marked neuroinflammation has been observed in brains of AD patients.Genetic and molecular biological findings have suggested the central nervous system(CNS)inflammatory processes to be involved in the etiopathogenesis of AD,in which the activated microglia play a key role.
