Dear Editor,I am Shoichiro Ota from Hokkaido University hospital,Japan.Conjunctival intraepithelial neoplasia(CIN)is a disease concept that includes dysplasia and carcinoma in situ.Pathologically,CIN is characterized ...Dear Editor,I am Shoichiro Ota from Hokkaido University hospital,Japan.Conjunctival intraepithelial neoplasia(CIN)is a disease concept that includes dysplasia and carcinoma in situ.Pathologically,CIN is characterized by tumor cell proliferation located within the epithelium with preservation of the basement membrane[1].In addition to histological diagnosis,anterior segment optical coherence tomography(ASOCT)plays an important role in clinical diagnosis,showing diffuse epithelial thickening with homogeneous high-intensity reflection in case of CIN[2-3].展开更多
Buchwald-Hartwig amination of 5,15-dibromo and 5,10-dibromo Ni(Ⅱ)porphyrins with 5-amino Ni(Ⅱ)porphyrin gave linear and bent trimers 4Ni and 5Ni with a central quinodiimine-type Ni(Ⅱ)porphyrinoid.The structures of ...Buchwald-Hartwig amination of 5,15-dibromo and 5,10-dibromo Ni(Ⅱ)porphyrins with 5-amino Ni(Ⅱ)porphyrin gave linear and bent trimers 4Ni and 5Ni with a central quinodiimine-type Ni(Ⅱ)porphyrinoid.The structures of 4Ni and 5Ni have been confirmed by X-ray diffraction analysis in both cases.The formation of unusual products 4Ni and 5Ni has been ascribed to facile oxidation of 5,15-and 5,10-amino Ni(Ⅱ)porphyrin unit.Reduction of 4Ni and 5Ni under proper conditions gave NH-bridged Ni(Ⅱ)porphyrin trimers 4Ni-2H and 5Ni-2H in high yields.Trimers 4Ni and 5Ni exhibit the lowest energy band as compared with 4Ni-2H and 5Ni-2H.Especially the bent trimer 5Ni exhibits a broad absorption tail beyond 1400 nm.展开更多
文摘Dear Editor,I am Shoichiro Ota from Hokkaido University hospital,Japan.Conjunctival intraepithelial neoplasia(CIN)is a disease concept that includes dysplasia and carcinoma in situ.Pathologically,CIN is characterized by tumor cell proliferation located within the epithelium with preservation of the basement membrane[1].In addition to histological diagnosis,anterior segment optical coherence tomography(ASOCT)plays an important role in clinical diagnosis,showing diffuse epithelial thickening with homogeneous high-intensity reflection in case of CIN[2-3].
基金supported by the National Natural Science Foundation of China(Nos.21772036,22071052,21602058,21702057)the Science and Technology Planning Project of Hunan Province(No.2018TP1017)+1 种基金the Scientific Research Fund of Hunan Provincial Education Department(No.19A331)Hunan Provincial Innovation Foundation for Postgraduate(No.CX20210473)。
文摘Buchwald-Hartwig amination of 5,15-dibromo and 5,10-dibromo Ni(Ⅱ)porphyrins with 5-amino Ni(Ⅱ)porphyrin gave linear and bent trimers 4Ni and 5Ni with a central quinodiimine-type Ni(Ⅱ)porphyrinoid.The structures of 4Ni and 5Ni have been confirmed by X-ray diffraction analysis in both cases.The formation of unusual products 4Ni and 5Ni has been ascribed to facile oxidation of 5,15-and 5,10-amino Ni(Ⅱ)porphyrin unit.Reduction of 4Ni and 5Ni under proper conditions gave NH-bridged Ni(Ⅱ)porphyrin trimers 4Ni-2H and 5Ni-2H in high yields.Trimers 4Ni and 5Ni exhibit the lowest energy band as compared with 4Ni-2H and 5Ni-2H.Especially the bent trimer 5Ni exhibits a broad absorption tail beyond 1400 nm.
