The Spontaneously Diabetic Torii (SDT) rat is a nonobese type 2 diabetic model, showing the overt hyperglycemia after about 16 weeks of age. In this study, we investigated the protein tyrosine phosphatase (PTPase) act...The Spontaneously Diabetic Torii (SDT) rat is a nonobese type 2 diabetic model, showing the overt hyperglycemia after about 16 weeks of age. In this study, we investigated the protein tyrosine phosphatase (PTPase) activities in insulin-sensitive tissues in SDT rats. PTPase activities in the liver, muscle, and fat were examined at 8 weeks (pre-diabetes), 16 weeks (onset-diabetes), and 24 weeks (diabetes). SDT rats showed glucose intolerance at 8 weeks and hyperglycemia after 16 weeks. The PTPase activities in fat increased at 8 weeks and the increase was sustained to 24 weeks. In the liver, PTPase activities increased only at 24 weeks. On the other hand, the PTPase activities in muscle did not change. The increase of PTPase activity in fat might be related to progression of glucose intolerance and diabetes in SDT rats.展开更多
Nutritional regulation plays a critical role to reduce the incidence or progression of diabetes mellitus. In this study, we investigated the effects of a high-fat diet on Spontaneously Diabetic Torii Leprfa (SDT fatty...Nutritional regulation plays a critical role to reduce the incidence or progression of diabetes mellitus. In this study, we investigated the effects of a high-fat diet on Spontaneously Diabetic Torii Leprfa (SDT fatty) rats, a novel model for obese type 2 diabetes. The SDT fatty rats were divided into two dietary groups, which were fed a high-fat diet or a standard diet for 18 weeks, from 6 to 24 weeks of age. The calorie intake in the high-fat diet (HF) group was reduced after 10 weeks of age and the group inhibited an incidence of diabetes. Interestingly, the HF induced an increase of serum glucagon-like peptide-1 (GLP-1) levels in SDT fatty rats with refeeding. Fat tissue weights in the HF group increased, but the visceral fat/subcutaneous fat (V/S) ratio decreased. Moreover, histopathological observations revealed an improvement of the pancreatic abnormalities and fatty liver in the HF group. In conclusion, a preventive effect on diabetes in rats fed a high-fat diet has a relation with an increase in incretin hormone, and it might be advantageous for prevention of incidence or progression of diabetes to develop functional foods inducing an increase in incretin hormone.展开更多
文摘The Spontaneously Diabetic Torii (SDT) rat is a nonobese type 2 diabetic model, showing the overt hyperglycemia after about 16 weeks of age. In this study, we investigated the protein tyrosine phosphatase (PTPase) activities in insulin-sensitive tissues in SDT rats. PTPase activities in the liver, muscle, and fat were examined at 8 weeks (pre-diabetes), 16 weeks (onset-diabetes), and 24 weeks (diabetes). SDT rats showed glucose intolerance at 8 weeks and hyperglycemia after 16 weeks. The PTPase activities in fat increased at 8 weeks and the increase was sustained to 24 weeks. In the liver, PTPase activities increased only at 24 weeks. On the other hand, the PTPase activities in muscle did not change. The increase of PTPase activity in fat might be related to progression of glucose intolerance and diabetes in SDT rats.
文摘Nutritional regulation plays a critical role to reduce the incidence or progression of diabetes mellitus. In this study, we investigated the effects of a high-fat diet on Spontaneously Diabetic Torii Leprfa (SDT fatty) rats, a novel model for obese type 2 diabetes. The SDT fatty rats were divided into two dietary groups, which were fed a high-fat diet or a standard diet for 18 weeks, from 6 to 24 weeks of age. The calorie intake in the high-fat diet (HF) group was reduced after 10 weeks of age and the group inhibited an incidence of diabetes. Interestingly, the HF induced an increase of serum glucagon-like peptide-1 (GLP-1) levels in SDT fatty rats with refeeding. Fat tissue weights in the HF group increased, but the visceral fat/subcutaneous fat (V/S) ratio decreased. Moreover, histopathological observations revealed an improvement of the pancreatic abnormalities and fatty liver in the HF group. In conclusion, a preventive effect on diabetes in rats fed a high-fat diet has a relation with an increase in incretin hormone, and it might be advantageous for prevention of incidence or progression of diabetes to develop functional foods inducing an increase in incretin hormone.
