Background: Many studies have shown that up- regulation of angiotensin- converting enzyme (ACE) participates in adverse fibrous remodeling. Although this has become an accepted fact in the cardiovascular field, the re...Background: Many studies have shown that up- regulation of angiotensin- converting enzyme (ACE) participates in adverse fibrous remodeling. Although this has become an accepted fact in the cardiovascular field, the relationship between ACE and cutaneous fibrous remodeling, such as keloid or hypertrophic scars, remains unknown. Objective: We sought to investigate ACE in normal skin, wounded skin, and pathologic scars. Methods: Ten samples undergoing a normal woundhealing process, 14 samples of pathologic scar tissue, and 15 samples of normal skin were used in this study. Cutaneous tissue ACE activities were measured with high- pressure liquid chromatography. Localization of ACE was assessed by immunohistochemistry. Results: The ACE activity in pathologic scar tissue was significantly higher than in normal and wounded skin. Immunohistochemical studies demonstrated that myofibroblasts were stained with anti- ACE antibody. Limitations: The study is small. Conclusions: These results suggest that up- regulated ACE may participate in cutaneous pathologic scar formation the same as the cardiovascular system.展开更多
Congenital malignant melanoma (MM) is an uncommon condition that is defined as MM recognized at birth. Its incidence is difficult to determine because of the small number of reported cases and because of problems asso...Congenital malignant melanoma (MM) is an uncommon condition that is defined as MM recognized at birth. Its incidence is difficult to determine because of the small number of reported cases and because of problems associated with diagnosis. Generally, Spitz naevus and melanoma have many clinical and histopathological similarities, so it is difficult to differentiate between the two. We describe a rare case of congenitalMM in which differential diagnosis from Spitz naevus was problematic. In addition, we review the literature and comment on the prognostic differences among the three types of congenital and infantile MM.展开更多
文摘Background: Many studies have shown that up- regulation of angiotensin- converting enzyme (ACE) participates in adverse fibrous remodeling. Although this has become an accepted fact in the cardiovascular field, the relationship between ACE and cutaneous fibrous remodeling, such as keloid or hypertrophic scars, remains unknown. Objective: We sought to investigate ACE in normal skin, wounded skin, and pathologic scars. Methods: Ten samples undergoing a normal woundhealing process, 14 samples of pathologic scar tissue, and 15 samples of normal skin were used in this study. Cutaneous tissue ACE activities were measured with high- pressure liquid chromatography. Localization of ACE was assessed by immunohistochemistry. Results: The ACE activity in pathologic scar tissue was significantly higher than in normal and wounded skin. Immunohistochemical studies demonstrated that myofibroblasts were stained with anti- ACE antibody. Limitations: The study is small. Conclusions: These results suggest that up- regulated ACE may participate in cutaneous pathologic scar formation the same as the cardiovascular system.
文摘Congenital malignant melanoma (MM) is an uncommon condition that is defined as MM recognized at birth. Its incidence is difficult to determine because of the small number of reported cases and because of problems associated with diagnosis. Generally, Spitz naevus and melanoma have many clinical and histopathological similarities, so it is difficult to differentiate between the two. We describe a rare case of congenitalMM in which differential diagnosis from Spitz naevus was problematic. In addition, we review the literature and comment on the prognostic differences among the three types of congenital and infantile MM.
