The effects of Chinese herbal medicines including Hachimi-jio-gan(HJG)and/or Hochu-ekki-to(HET)on osteopenia inrats were investigated.The Chinese herbal medicines were administrated for 8 weeks(7 times/week)starling f...The effects of Chinese herbal medicines including Hachimi-jio-gan(HJG)and/or Hochu-ekki-to(HET)on osteopenia inrats were investigated.The Chinese herbal medicines were administrated for 8 weeks(7 times/week)starling from 1 weekafter ovariectomy.HJG and Prescription-2(Prsc-2,the prescription based on HJG)showed protective effect on bone loss ofthe vertebrae after ovariectomy.However,Prescription-1(the prescription based on HJG and HE-T)had no effect.Then,wemade osteopenia model in rats by prednisolone and low calcium diet.Prsc-2 and HJG were administrated for 20 weeks withprednisolone.These Chinese remedies showed protective effects for osteopenia,with better indices on bone loss of the limbsthan HJG alone in the osteopenia rats.It can be concluded that Prsc-2 is more effective than HJG for bone loss induced byvarious factors,and the additives in Prsc-2 may enhance the therapeutic effect.展开更多
In the adenine-induced renal failure rats, reversibility of renal failure and recovery of bone mineral density (BMD) by discontinuation of adenine-rich diet were reported: We think that the effect to bone metabolism w...In the adenine-induced renal failure rats, reversibility of renal failure and recovery of bone mineral density (BMD) by discontinuation of adenine-rich diet were reported: We think that the effect to bone metabolism with medication may be able to be evaluated as reinforcement of the BMD recovery. We have so far investigated the Chinese herbal medicine based on Hachimi-jio-gan (HJG) which are more effective than HJG alone. In this study, we investigated the effects of our Chinese herbal prescription on BMD in the adenine-treated rats compared to that of vitamin D3treatment. Young male rats were administrated 100 mg/ml adenine for 8 weeks, and they showed renal failure and bone loss. The adenine-treated rats were divided into the following 3 groups, that is, the group experienced no treatment (control), the group givenour Chinese herbal medicine (HAO), and the group given vitamin D3 (VD3) medication. It is likely that VD3 medication was less effective for increase of the femoral BMD than increase of the spinal BMD. In contrast, HAO was effective for increase of the femoral BMD. The VD3 group showed low deoxypyridinoline (Dpd: bone resorption maker) as compared to the control group.However, the HAO group showed same or slightly high Dpd. It is suggested that VD3 may increase BMD by reduction of bone resorption, while HAO may show effect on BMD by activating bone metabolism. It is indicated that HAO may become a curative medicine for bone loss because of the different target site from vitamin D3.展开更多
文摘The effects of Chinese herbal medicines including Hachimi-jio-gan(HJG)and/or Hochu-ekki-to(HET)on osteopenia inrats were investigated.The Chinese herbal medicines were administrated for 8 weeks(7 times/week)starling from 1 weekafter ovariectomy.HJG and Prescription-2(Prsc-2,the prescription based on HJG)showed protective effect on bone loss ofthe vertebrae after ovariectomy.However,Prescription-1(the prescription based on HJG and HE-T)had no effect.Then,wemade osteopenia model in rats by prednisolone and low calcium diet.Prsc-2 and HJG were administrated for 20 weeks withprednisolone.These Chinese remedies showed protective effects for osteopenia,with better indices on bone loss of the limbsthan HJG alone in the osteopenia rats.It can be concluded that Prsc-2 is more effective than HJG for bone loss induced byvarious factors,and the additives in Prsc-2 may enhance the therapeutic effect.
文摘In the adenine-induced renal failure rats, reversibility of renal failure and recovery of bone mineral density (BMD) by discontinuation of adenine-rich diet were reported: We think that the effect to bone metabolism with medication may be able to be evaluated as reinforcement of the BMD recovery. We have so far investigated the Chinese herbal medicine based on Hachimi-jio-gan (HJG) which are more effective than HJG alone. In this study, we investigated the effects of our Chinese herbal prescription on BMD in the adenine-treated rats compared to that of vitamin D3treatment. Young male rats were administrated 100 mg/ml adenine for 8 weeks, and they showed renal failure and bone loss. The adenine-treated rats were divided into the following 3 groups, that is, the group experienced no treatment (control), the group givenour Chinese herbal medicine (HAO), and the group given vitamin D3 (VD3) medication. It is likely that VD3 medication was less effective for increase of the femoral BMD than increase of the spinal BMD. In contrast, HAO was effective for increase of the femoral BMD. The VD3 group showed low deoxypyridinoline (Dpd: bone resorption maker) as compared to the control group.However, the HAO group showed same or slightly high Dpd. It is suggested that VD3 may increase BMD by reduction of bone resorption, while HAO may show effect on BMD by activating bone metabolism. It is indicated that HAO may become a curative medicine for bone loss because of the different target site from vitamin D3.
