The development of novel drugs to overcome the current global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an important task.Although antiviral age...The development of novel drugs to overcome the current global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an important task.Although antiviral agents have been investigated,one of the important goals of treatment is also to control the biological response to the infection.A series of elegant basic studies have revealed that lysophosphatidylserine(LysoPS)might play important roles in inflammation through three kinds of G protein-coupled receptors[1];LysoPS reportedly suppresses activation of T cells[2]and secretion of inflammatory cytokines from macrophages[3]and promotes phagocytosis of apoptotic cells,including apoptotic neutrophils,by macrophages[4].展开更多
基金This work was supported by Research Grants in the Natural Sciences from the Mitsubishi Foundation(MK)Leading Advanced Projects for medical innovation(LEAP)from AMED(JA and YY).
文摘The development of novel drugs to overcome the current global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an important task.Although antiviral agents have been investigated,one of the important goals of treatment is also to control the biological response to the infection.A series of elegant basic studies have revealed that lysophosphatidylserine(LysoPS)might play important roles in inflammation through three kinds of G protein-coupled receptors[1];LysoPS reportedly suppresses activation of T cells[2]and secretion of inflammatory cytokines from macrophages[3]and promotes phagocytosis of apoptotic cells,including apoptotic neutrophils,by macrophages[4].
