Due to their unique activation modes,small organic molecule catalysts(organocatalysts)have proved their potential in facilitating the remote functionalizations of unsaturated acceptors with extended conjugation.The or...Due to their unique activation modes,small organic molecule catalysts(organocatalysts)have proved their potential in facilitating the remote functionalizations of unsaturated acceptors with extended conjugation.The organocatalytic 1,6-addition reaction involving the attack of nucleophiles on the δ-carbon of the α,β,γ,δ-unsaturated acceptors has emerged as an excellent strategy to create a stereocenter at the δ-site with high regio-and stereo-control.Organocatalysis has also opened the window for developing complex domino reactions involving the 1,6-addition step.Tremendous advancement has been accomplished in the organocatalytic asymmetric 1,6-addition and related domino reactions for the stereocontrolled synthesis of complex molecular structures bearing multiple stereocenters.This review article summarizes the significant advancement in stereoselective domino reactions involving 1,6-addition as a critical step.展开更多
基金financial support from the Council of Scientific and Industrial Research(CSIR),India(File No.:02(0422)/21/EMR-Ⅱ)the Indian Institute of Technology Jammu for providing Seed Grant(File No.:SG0002)to establish the independent research groupthe Indian Institute of Technology Jammu for the fellowships.
文摘Due to their unique activation modes,small organic molecule catalysts(organocatalysts)have proved their potential in facilitating the remote functionalizations of unsaturated acceptors with extended conjugation.The organocatalytic 1,6-addition reaction involving the attack of nucleophiles on the δ-carbon of the α,β,γ,δ-unsaturated acceptors has emerged as an excellent strategy to create a stereocenter at the δ-site with high regio-and stereo-control.Organocatalysis has also opened the window for developing complex domino reactions involving the 1,6-addition step.Tremendous advancement has been accomplished in the organocatalytic asymmetric 1,6-addition and related domino reactions for the stereocontrolled synthesis of complex molecular structures bearing multiple stereocenters.This review article summarizes the significant advancement in stereoselective domino reactions involving 1,6-addition as a critical step.
