Tumor hypoxia is one of the hostile tumor micro-environment characteristics occurring in solid tumors.This feature is closely related to tumor progression and can negatively impair the effec-tiveness of cancer therape...Tumor hypoxia is one of the hostile tumor micro-environment characteristics occurring in solid tumors.This feature is closely related to tumor progression and can negatively impair the effec-tiveness of cancer therapeutics.Recently,various strategies have been developed that enable effi-cient tumor oxygenation,not only enhancing tre-atment outcome of oxygen-consuming cancer therapeutics such as radiotherapy and photody-namic therapy,but also reversing the immunosup-pressive tumor microenvironment to promote cancer immunotherapy.This review focuses on the latest progress in design and fabrication of inno-vative tumor-targeted oxygen nanoshuttles that attenuate tumor hypoxia and enhance cancer therapy.Future perspectives for clinical translation of tumor-targeted oxygen nanoshuttles will be fur-ther discussed.展开更多
基金This work was partially supported by the National Re-search Programs from Ministry of Science and Technol-ogy(MOST)of China(2016YFA0201200)the National Natural Science Foundation of China(51525203,51761145041,and 51802209)+3 种基金the Natural Science Foun-dation of Jiangsu Province(BK20180848)the China Postdoctoral Science Foundation(2017M610348 and 2018T110545)Collaborative Innovation Center of Suz-hou Nano Science and Technology,the 111 Program from the Ministry of Education of China,a project funded by the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions,the Joint NSFC-ISF Research Grant no.2533/17by the council for higher education postdoctoral fellowship for outstanding wom-an in Science for Oshra Betzer,and the industry-academy postdoctoral scholarship(3-15677)from the Ministry of Science,Technology&Space Israel for Oshra Betzer.
文摘Tumor hypoxia is one of the hostile tumor micro-environment characteristics occurring in solid tumors.This feature is closely related to tumor progression and can negatively impair the effec-tiveness of cancer therapeutics.Recently,various strategies have been developed that enable effi-cient tumor oxygenation,not only enhancing tre-atment outcome of oxygen-consuming cancer therapeutics such as radiotherapy and photody-namic therapy,but also reversing the immunosup-pressive tumor microenvironment to promote cancer immunotherapy.This review focuses on the latest progress in design and fabrication of inno-vative tumor-targeted oxygen nanoshuttles that attenuate tumor hypoxia and enhance cancer therapy.Future perspectives for clinical translation of tumor-targeted oxygen nanoshuttles will be fur-ther discussed.
