A number of beach-bar sandstone reservoir beds are developed in the upper fourth member of the Eocene Shahejie Formation (Es4s) on the southern slope of the Dongying Sag.Based on the analysis of seismic and logging ...A number of beach-bar sandstone reservoir beds are developed in the upper fourth member of the Eocene Shahejie Formation (Es4s) on the southern slope of the Dongying Sag.Based on the analysis of seismic and logging data,with characterization and petrographic studies of core and cutting samples,this paper analyzes the hydrocarbon accumulation characteristics in two typical blocks of the Boxing and Wangjiagang oilfields,especially reservoir bed heterogeneity and migration conditions that influence oil and gas distribution,calculates the index of reservoir bed quality (IRQ) with a mathematical method,and discusses the relationship between driving force and resistance of hydrocarbon accumulation.Taking into account the characteristics of thin interbeds in beach-bar sandstones,an experimental model simulated the characteristics of hydrocarbon migration and accumulation in thin interbedded sandstones with reservoir bed heterogeneity.The results showed that hydrocarbon distribution and properties were extremely non-uniform.Reservoir bed and migration conditions controlled hydrocarbon accumulation in beach-bar sandstones.IRQ is above 0.4 in the main hydrocarbon region.Sand body distribution,structural configuration and fault systems controlled the direction of regional migration and location of hydrocarbon accumulation.Simulation experiments indicated that the change of driving force for hydrocarbon migration affected selective accumulation mechanisms.Hydrocarbon moved vertically along fault zones to the reservoir and resulted in the distribution of hydrocarbon in the reservoir.Two kinds of hydrocarbon accumulation models exist in the study area.One is a hydrocarbon accumulation model controlled by reservoir bed heterogeneity and the second is a hydrocarbon accumulation model controlled by a complex migration system with faults connecting sandbodies.Finally,different exploration strategies should be adopted for the detailed exploration for beach-bar sandstone reservoirs according to different geological backgrounds.展开更多
目的基于生物信息学分析平台探讨龟芍平颤方抗帕金森病的分子机制。方法从1994年4月~2019年12月的中英文数据库(中国期刊全文数据库、维普期刊全文数据库、中国生物医学文献数据库、中华本草、PubMed、Web of Science、SciFinder Schol...目的基于生物信息学分析平台探讨龟芍平颤方抗帕金森病的分子机制。方法从1994年4月~2019年12月的中英文数据库(中国期刊全文数据库、维普期刊全文数据库、中国生物医学文献数据库、中华本草、PubMed、Web of Science、SciFinder Scholar)中获得龟芍平颤方(龟甲、白芍、川芎、天麻)的化学成分,并于PubChem数据库中查找该方每种有效成分的人源活性靶蛋白。检索Gene数据库,查找帕金森病相关人源基因。将上述靶蛋白与基因上传至生物信息学分析平台,分析两者共同涉及的分子网络与生物学通路。结果获得龟芍平颤方人源活性靶蛋白323个(龟甲58个、白芍119个、川芎72个、天麻74个);获取帕金森病相关人源基因392个。建立上述靶蛋白及基因共同作用的主要分子网络,并甄选出G-蛋白偶联受体信号传导通路等10条主要的生物学通路。结论龟芍平颤方可能通过调控G-蛋白偶联受体信号传导通路等发挥抗帕金森病作用。展开更多
基金financially supported by National Major Projects of Fine Characterization of Complex Hydrocarbon Reservoir and Prediction of Remaining Oil Distribution (No. 20095009-003)
文摘A number of beach-bar sandstone reservoir beds are developed in the upper fourth member of the Eocene Shahejie Formation (Es4s) on the southern slope of the Dongying Sag.Based on the analysis of seismic and logging data,with characterization and petrographic studies of core and cutting samples,this paper analyzes the hydrocarbon accumulation characteristics in two typical blocks of the Boxing and Wangjiagang oilfields,especially reservoir bed heterogeneity and migration conditions that influence oil and gas distribution,calculates the index of reservoir bed quality (IRQ) with a mathematical method,and discusses the relationship between driving force and resistance of hydrocarbon accumulation.Taking into account the characteristics of thin interbeds in beach-bar sandstones,an experimental model simulated the characteristics of hydrocarbon migration and accumulation in thin interbedded sandstones with reservoir bed heterogeneity.The results showed that hydrocarbon distribution and properties were extremely non-uniform.Reservoir bed and migration conditions controlled hydrocarbon accumulation in beach-bar sandstones.IRQ is above 0.4 in the main hydrocarbon region.Sand body distribution,structural configuration and fault systems controlled the direction of regional migration and location of hydrocarbon accumulation.Simulation experiments indicated that the change of driving force for hydrocarbon migration affected selective accumulation mechanisms.Hydrocarbon moved vertically along fault zones to the reservoir and resulted in the distribution of hydrocarbon in the reservoir.Two kinds of hydrocarbon accumulation models exist in the study area.One is a hydrocarbon accumulation model controlled by reservoir bed heterogeneity and the second is a hydrocarbon accumulation model controlled by a complex migration system with faults connecting sandbodies.Finally,different exploration strategies should be adopted for the detailed exploration for beach-bar sandstone reservoirs according to different geological backgrounds.
文摘目的基于生物信息学分析平台探讨龟芍平颤方抗帕金森病的分子机制。方法从1994年4月~2019年12月的中英文数据库(中国期刊全文数据库、维普期刊全文数据库、中国生物医学文献数据库、中华本草、PubMed、Web of Science、SciFinder Scholar)中获得龟芍平颤方(龟甲、白芍、川芎、天麻)的化学成分,并于PubChem数据库中查找该方每种有效成分的人源活性靶蛋白。检索Gene数据库,查找帕金森病相关人源基因。将上述靶蛋白与基因上传至生物信息学分析平台,分析两者共同涉及的分子网络与生物学通路。结果获得龟芍平颤方人源活性靶蛋白323个(龟甲58个、白芍119个、川芎72个、天麻74个);获取帕金森病相关人源基因392个。建立上述靶蛋白及基因共同作用的主要分子网络,并甄选出G-蛋白偶联受体信号传导通路等10条主要的生物学通路。结论龟芍平颤方可能通过调控G-蛋白偶联受体信号传导通路等发挥抗帕金森病作用。