Many patients with chronic idiopathic urticaria are not sufficiently controlled with histamine H1-receptor antagonists. Leukotriene receptor antagonists have been reported to be effective for certain cases of urticari...Many patients with chronic idiopathic urticaria are not sufficiently controlled with histamine H1-receptor antagonists. Leukotriene receptor antagonists have been reported to be effective for certain cases of urticaria, although their proper application remains to be established. To study the effectiveness of montelukast, a leukotriene receptor antagonist, for the treatment of chronic urticaria that was not controlled by histamine H1-receptor antagonists. Twenty-five pat ients with chronic idiopathic urticaria were treated with 10 mg of montelukast f or one week or more, without changing any precedent treatment that they were usi ng before the study including histamine H1-receptor antagonists. The effectiven ess of montelukast for each patient was evaluated and compared with clinical fea tures and/or backgrounds of the patients. Twelve patients, including six who had been treated with corticosteroids, were evaluated as “markedly improved”or “ improved”following treatment with montelukast. There was no statistically signi ficant relation of the effectiveness to the complications with non-steroidal an ti-inflammatory drugs (NSAIDs) intolerance, mechanical urticaria, or reactions to autologous serum skin test. However, the patients for whom montelukastwas eff ective were younger (33.2±16.3 years, mean ±SD)(P < 0.05, Mann-Whitney test) and their duration of illness shorter (15.9±18.3 months) (P < 0.005, Mann-Whit ney test) than those of patients for whom montelukast was ineffective (45.9±15. 0 years, 89.6±71.7 months). Montelukast may be worth trying for patientswith ch ronic idiopathic urticaria,when the condition is not sufficiently controlled wit h histamine H1-receptor antagonists.展开更多
文摘Many patients with chronic idiopathic urticaria are not sufficiently controlled with histamine H1-receptor antagonists. Leukotriene receptor antagonists have been reported to be effective for certain cases of urticaria, although their proper application remains to be established. To study the effectiveness of montelukast, a leukotriene receptor antagonist, for the treatment of chronic urticaria that was not controlled by histamine H1-receptor antagonists. Twenty-five pat ients with chronic idiopathic urticaria were treated with 10 mg of montelukast f or one week or more, without changing any precedent treatment that they were usi ng before the study including histamine H1-receptor antagonists. The effectiven ess of montelukast for each patient was evaluated and compared with clinical fea tures and/or backgrounds of the patients. Twelve patients, including six who had been treated with corticosteroids, were evaluated as “markedly improved”or “ improved”following treatment with montelukast. There was no statistically signi ficant relation of the effectiveness to the complications with non-steroidal an ti-inflammatory drugs (NSAIDs) intolerance, mechanical urticaria, or reactions to autologous serum skin test. However, the patients for whom montelukastwas eff ective were younger (33.2±16.3 years, mean ±SD)(P < 0.05, Mann-Whitney test) and their duration of illness shorter (15.9±18.3 months) (P < 0.005, Mann-Whit ney test) than those of patients for whom montelukast was ineffective (45.9±15. 0 years, 89.6±71.7 months). Montelukast may be worth trying for patientswith ch ronic idiopathic urticaria,when the condition is not sufficiently controlled wit h histamine H1-receptor antagonists.
