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Immunological Status to Hepatitis B Virus of Pregnant Women in Dakar, Senegal
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作者 Maguette Sylla Niang Khadidiatou Sarr Fall +9 位作者 Babacar Mbengue Moustapha Mbow Ndiokhor Nd. Diouf Ousseynou Boye Gora Lo Papa Madieye Guèye Rena Derwiche Amina Sow Sall tandakha ndiaye dieye Alioune dieye 《Open Journal of Immunology》 2017年第2期37-44,共8页
Objective: Evaluate the immunological status to hepatitis B virus of Senegalese pregnant women by screening HBs antigen. Material and methods: The selection criteria of women were presence at the laboratory for biolog... Objective: Evaluate the immunological status to hepatitis B virus of Senegalese pregnant women by screening HBs antigen. Material and methods: The selection criteria of women were presence at the laboratory for biological exams of pregnancy follow-up. All volunteers for the study were screened for HBs antigen (HBs Ag). Investigation of chronic hepatitis B markers (HBe Ag, anti-HBe, viral quantification) was performed in HBs Ag positive participants. The concentration of anti-HBs antibodies was assessed in HBs Ag negative women. Results: One hundred and fifteen (115) pregnant women were included in the study from July to October 2014. The mean age was 29 ± 6 years, ranging from 16 to 47. The seroprevalence of HBs Ag was 12% and the majority of women (90%) were not vaccinated. Any of the 14 HBs Ag-positive subjects did not express serum HBe Ag, (marker of active viral replication) and all were positive for anti-HBe antibodies. Their viral load (HBV DNA) was undetectable and serum transaminases were normal. The anti-HBs antibodies titrated in HBs-Ag negative women serum revealed that only 46 had protective levels against HBV whilst 55 of them were unprotected. 展开更多
关键词 HBS Ag PREGNANCY Senegal
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