[背景]近年来,青少年电子烟使用率不断上升,且电子烟相关肺损伤病例激增,引起各领域研究人员的关注。[目的]通过文献计量学及可视化分析探讨2013-2022年全球范围内电子烟或电子烟产品使用相关肺损伤(EVALI)的研究热点与趋势。[方法]选用...[背景]近年来,青少年电子烟使用率不断上升,且电子烟相关肺损伤病例激增,引起各领域研究人员的关注。[目的]通过文献计量学及可视化分析探讨2013-2022年全球范围内电子烟或电子烟产品使用相关肺损伤(EVALI)的研究热点与趋势。[方法]选用Web of Science核心数据库,获取2013-2022年全球EVALI相关的文献,从国家/地区、机构、作者、期刊、被引文献、关键词等方面进行统计,采用CiteSpace 6.2.R1绘制发文量趋势分析图、作者合作网络分析图、论文共被引聚类时间分布图、关键词聚类分析图等图谱,并对数据进行可视化分析。[结果]通过检索,2013-2022年间EVALI相关研究的文献共有888篇。发文量逐年增加,在2020年增幅明显,从2021年开始有所下降,但引用量逐年增加。发文量最活跃的国家是美国(631篇),欧美国家合作紧密且中心性更为突出,发文机构中加州大学系统以103篇居榜首。Rahman I (27篇)发表论文最多,中心度较高;Goniewicz M L被引文献最多;网络分析图显示作者间的合作相对较弱。American Journal of Respiratory and Critical Care Medicine(《美国呼吸与重症监护医学杂志》)是发文量最高的期刊(94篇)。被引次数前5名的文献均被引用超过300次。EVALI相关研究的高频关键词依次是nicotine(尼古丁,149次),exposure(暴露,118次)、oxidative stress(氧化应激,80次)等。共同引用网络中关键节点的聚类和聚类时间分布图表明青少年电子烟成瘾开始受到社会的广泛关注。从突现分析得到排名前25个关键词来看,对EVALI发病机制的研究重点逐渐从电子烟蒸气对肺产生的氧化应激损伤转向调味化学物质在肺损伤过程中发挥的氧化作用,目前该领域研究的兴趣主要是电子烟中各种化学物质以及加热元件对肺的损伤机制。[结论] EVALI正受到政府、医疗机构等领域研究人员的持续关注。多种电子烟成分如调味化学物质产生了不同程度的细胞毒性、炎症和肺损伤。但EVALI的病理生理机制仍不清楚,未来应鼓励更多的中国学者参与该领域研究。展开更多
OBJECTIVE: To verify the Traditional Chinese Medicine(TCM) theory that kidney-Qi deficiency(KQD)is considered to be the main cause of aging using cross-sectional study.METHODS: Demographic and lifestyle characteristic...OBJECTIVE: To verify the Traditional Chinese Medicine(TCM) theory that kidney-Qi deficiency(KQD)is considered to be the main cause of aging using cross-sectional study.METHODS: Demographic and lifestyle characteristics of 90 healthy participants were collected with a self-administered questionnaire. KQD syndrome was diagnosed according to Deng's diagnosis standard. Creatinine-adjusted urinary 8-hydroxy-2'-deoxyguanosine(8-OH-dG) and 8-isomeric-prostaglandin2α(8-iso-PGF2α), salivary advanced oxidation protein products(AOPPs), malondialdehyde(MDA) and dehydroepiandrosterone-sulfate(DHEA-S) were selected as aging markers and measured using enzyme-linked immunosorbent assay.RESULTS: No significant differences were observed in participant characteristics between the KQD group and non-KQD(NKQD) group(P > 0.05). Levels of 8-OH-dG, 8-iso-PGF2α, AOPPs, and MDA increased with age, except for a slight decrease in8-OH-dG in the older group. The increase in8-iso-PGF2α was significant(P < 0.05). DHEA-S significantly decreased with increasing age(P < 0.01).8-OH-dG levels were higher in the KQD group compared with the NKQD group. Levels of urinary8-iso-PGF2α, salivary AOPPs, and MDA in the KQD group were lower than in the NKQD group. Salivary DHEA-S was higher in the KQD group compared with the NKQD group. However, differences between KQD group and NKQD group were not significant.CONCLUSION: The current results suggested that KQD syndrome, as diagnosed by Deng's standard,does not underlie the aging phenotype.展开更多
文摘[背景]近年来,青少年电子烟使用率不断上升,且电子烟相关肺损伤病例激增,引起各领域研究人员的关注。[目的]通过文献计量学及可视化分析探讨2013-2022年全球范围内电子烟或电子烟产品使用相关肺损伤(EVALI)的研究热点与趋势。[方法]选用Web of Science核心数据库,获取2013-2022年全球EVALI相关的文献,从国家/地区、机构、作者、期刊、被引文献、关键词等方面进行统计,采用CiteSpace 6.2.R1绘制发文量趋势分析图、作者合作网络分析图、论文共被引聚类时间分布图、关键词聚类分析图等图谱,并对数据进行可视化分析。[结果]通过检索,2013-2022年间EVALI相关研究的文献共有888篇。发文量逐年增加,在2020年增幅明显,从2021年开始有所下降,但引用量逐年增加。发文量最活跃的国家是美国(631篇),欧美国家合作紧密且中心性更为突出,发文机构中加州大学系统以103篇居榜首。Rahman I (27篇)发表论文最多,中心度较高;Goniewicz M L被引文献最多;网络分析图显示作者间的合作相对较弱。American Journal of Respiratory and Critical Care Medicine(《美国呼吸与重症监护医学杂志》)是发文量最高的期刊(94篇)。被引次数前5名的文献均被引用超过300次。EVALI相关研究的高频关键词依次是nicotine(尼古丁,149次),exposure(暴露,118次)、oxidative stress(氧化应激,80次)等。共同引用网络中关键节点的聚类和聚类时间分布图表明青少年电子烟成瘾开始受到社会的广泛关注。从突现分析得到排名前25个关键词来看,对EVALI发病机制的研究重点逐渐从电子烟蒸气对肺产生的氧化应激损伤转向调味化学物质在肺损伤过程中发挥的氧化作用,目前该领域研究的兴趣主要是电子烟中各种化学物质以及加热元件对肺的损伤机制。[结论] EVALI正受到政府、医疗机构等领域研究人员的持续关注。多种电子烟成分如调味化学物质产生了不同程度的细胞毒性、炎症和肺损伤。但EVALI的病理生理机制仍不清楚,未来应鼓励更多的中国学者参与该领域研究。
基金Supported by Shanghai Municipal Commission of Health and Family Planning Project:Preliminary Study on the Construction of Asthma Integrative Medicine Management Platform based on Smart Devices and Mobile Internet(No.ZYKC201602001)
文摘OBJECTIVE: To verify the Traditional Chinese Medicine(TCM) theory that kidney-Qi deficiency(KQD)is considered to be the main cause of aging using cross-sectional study.METHODS: Demographic and lifestyle characteristics of 90 healthy participants were collected with a self-administered questionnaire. KQD syndrome was diagnosed according to Deng's diagnosis standard. Creatinine-adjusted urinary 8-hydroxy-2'-deoxyguanosine(8-OH-dG) and 8-isomeric-prostaglandin2α(8-iso-PGF2α), salivary advanced oxidation protein products(AOPPs), malondialdehyde(MDA) and dehydroepiandrosterone-sulfate(DHEA-S) were selected as aging markers and measured using enzyme-linked immunosorbent assay.RESULTS: No significant differences were observed in participant characteristics between the KQD group and non-KQD(NKQD) group(P > 0.05). Levels of 8-OH-dG, 8-iso-PGF2α, AOPPs, and MDA increased with age, except for a slight decrease in8-OH-dG in the older group. The increase in8-iso-PGF2α was significant(P < 0.05). DHEA-S significantly decreased with increasing age(P < 0.01).8-OH-dG levels were higher in the KQD group compared with the NKQD group. Levels of urinary8-iso-PGF2α, salivary AOPPs, and MDA in the KQD group were lower than in the NKQD group. Salivary DHEA-S was higher in the KQD group compared with the NKQD group. However, differences between KQD group and NKQD group were not significant.CONCLUSION: The current results suggested that KQD syndrome, as diagnosed by Deng's standard,does not underlie the aging phenotype.
