A transition metal-free synthesis of β-(pyridin-2-yl)-methyl ketones,using(pyridin-2-yl)methyl alcohols and ketones through the 2-pyridinylmethyl borrowing strategy,has been disclosed.This approach provides an effici...A transition metal-free synthesis of β-(pyridin-2-yl)-methyl ketones,using(pyridin-2-yl)methyl alcohols and ketones through the 2-pyridinylmethyl borrowing strategy,has been disclosed.This approach provides an efficient,available and environmentally benign access,leading to alkylation products with broad functional group tolerance and excellent yields.Meanwhile,the selective cleavage of unactivated C(sp^(3))-C(sp^(3))bonds of common secondary alcohols was achieved with high atom economy.展开更多
基金the financial support provided by the National Natural Science Foundation of China(21801209 and 21801210)the Fundamental Research Funds for the Central Universities(SWU118117,SWU118028 and XDJK2019AA003)+1 种基金the Venture&Innovation Support Program for Chongqing Overseas Returnees(cx2018085)the Natural Science Foundation of Chongqing,China(cstc2020jcyj-msxmX0130).
文摘A transition metal-free synthesis of β-(pyridin-2-yl)-methyl ketones,using(pyridin-2-yl)methyl alcohols and ketones through the 2-pyridinylmethyl borrowing strategy,has been disclosed.This approach provides an efficient,available and environmentally benign access,leading to alkylation products with broad functional group tolerance and excellent yields.Meanwhile,the selective cleavage of unactivated C(sp^(3))-C(sp^(3))bonds of common secondary alcohols was achieved with high atom economy.
