Prognostic Value of Neutrophil to Lymphocyte Ratio for In-hospital Mortality in Elderly Patients with Acute Myocardial Infarction

Coronary artery disease （CAD） is a multifactorial disease in which inflammation plays a central role. This study aimed to investigate the association of inflammatory markers such as the neutrophil to lymphocyte ratio （NLR）, the Global Registry of Acute Coronary Events （GRACE） score with in-hospital mortality of elderly patients with acute myocardial infarction （AMI） in an attempt to explore the prognostic value of these indices for elderly AMI patients. One thousand consecutive CAD patients were divided into two groups based on age 60. The laboratory and clinical characteristics were assessed retrospectively by reviewing the medical records. The NLR and GRACE score were calculated. In the elderly （〉60 years）, patients with non-ST-elevation myocardial infarction （NSTEMI） and ST-elevation myocardial infarction （STEMI） had significantly higher NLR than did those with unstable angina （UA） and stable angina pectoris （SAP） （P〈0.01）. The NLR was considerably elevated in older AMI patients compared with their younger counterparts （〈60 years） （P〈0.05）. In elderly AMI patients, the NLR was considerably higher in the high-risk group than in both the low-risk and mediumrisk groups based on the GRACE score （P〈0.05 and P〈0.01, respectively）, and the NLR was positively correlated with the GRACE score （r=0.322, P〈0.001）. Either the NLR level or the GRACE score was significantly higher in the death group than in the surviving group （P〈0.05）. By curve receiver operator characteristic curve （ROC） analysis, the optimal cut-off levels of 9.41 for NLR and 174 for GRACE score predicted in-hospital death [ROC area under the curve （AUC） 0.771 and 0.787, respectively, P〈0.001]. It was concluded that an elevated NLR is a potential predictor of in-hospital mortality in elderly patients with AMI.

Pentraxin 3 （PTX3） promoter methylation associated with PTX3 plasma levels and neutrophil to lymphocyte ratio in coronary artery disease

BackgroundPentraxin 3 (PTX3 ) 在煽动性的条件下面在心被表示并且在 atherogenesis 起一个重要作用。有增加的 PTX3 层次的病人可以受不了心脏的事件的更高的率。由倡导者 methylation 的特定的基因的规定在 atherogenesis 是重要的。影响在 epigenetics 之间的 PTX3 层次和 PTX3 层次的因素一直不是 investigated.MethodsBlood 样品从进入心病学的部门的 64 个病人被收集， 35 有冠的动脉疾病(CAD ) ，并且 29 是没有 CAD 的。PTX3 的血浆层次被 ELISA 测量。PTX3 倡导者 methylation 经由甲基特定的 PCR 被评估。冠的动脉损害的严厉被 PTX3 倡导者 methylation 的 angiography.ResultsThe 水平在 CAD 组评估是 62.69%&#x000b1；20.57% ，显著地比没有 CAD 的组的降低，它是 72.45%&#x000b1；11.84%(P = 0.03 ) 。在 CAD 组的更低的 PTX3 倡导者 methylation 层次与更高的血浆 PTX3 集中被联系(r =&#x02212； 0.29， P = 0.02 ) 。而且，更低的 PTX3 倡导者 methylation 层次与被联系对在人的淋巴细胞比率(NLR ) 更高嗜中性(r =&#x02212； 0.58， P = 0.002 ) 学习提供的在场的 .ConclusionsThe PTX3 倡导者的 methylation 在冠的动脉疾病与 PTX3 血浆层次和 NLR 被联系的新证据。这研究也证明由长期的发炎的 epigenetics 的那修正可能是在影响血浆 PTX3 集中的动脉粥样硬化患者过程的重要分子的机制。