The protective effects of iptakalim hydrochloride (Ipt) 0.5-4.0mg·kg^-1 ip on global cerebral ischemia/reperfusion-evoked insult in gerbil were studied using bilateral carotid artery ligation to prepare the globa...The protective effects of iptakalim hydrochloride (Ipt) 0.5-4.0mg·kg^-1 ip on global cerebral ischemia/reperfusion-evoked insult in gerbil were studied using bilateral carotid artery ligation to prepare the global cerebral ischemia model.The NMDA receptor blocker,ketamine was administered as a positive control drug and saling was administered as a negative model control.The results shown that Ipt decreased the increasing locomotor activity evoked by ischemia and had reliable functional protection of ischemia-induced hippocampus injury.Ipt could also improve global cerebral ischemia-induced working memory impairments.Ipt decreased the number of necrotic and apoptotic neurons and increased the remaining number of healthy neurons in hippocampus CAl zone.Ipt promoted the recovery of hippocampus function.Ipt reversed ischemia-evoked increases of grutamate,aspartate,glycine and glutamine in hippocampus,striatum and cortex of gerbils completely and reversed the increase of GABA and taurine partly.It is concluded that Ipt has experimental therapeutic effects on global cerebral ischemia.展开更多
文摘The protective effects of iptakalim hydrochloride (Ipt) 0.5-4.0mg·kg^-1 ip on global cerebral ischemia/reperfusion-evoked insult in gerbil were studied using bilateral carotid artery ligation to prepare the global cerebral ischemia model.The NMDA receptor blocker,ketamine was administered as a positive control drug and saling was administered as a negative model control.The results shown that Ipt decreased the increasing locomotor activity evoked by ischemia and had reliable functional protection of ischemia-induced hippocampus injury.Ipt could also improve global cerebral ischemia-induced working memory impairments.Ipt decreased the number of necrotic and apoptotic neurons and increased the remaining number of healthy neurons in hippocampus CAl zone.Ipt promoted the recovery of hippocampus function.Ipt reversed ischemia-evoked increases of grutamate,aspartate,glycine and glutamine in hippocampus,striatum and cortex of gerbils completely and reversed the increase of GABA and taurine partly.It is concluded that Ipt has experimental therapeutic effects on global cerebral ischemia.
