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Neuroprotective effect of Neuro-EPO in neurodegenerative diseases:“Alea jacta est”
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作者 Ramón Rama Fernando Garzón +2 位作者 Yamila Rodríguez-Cruz tangui maurice Julio-César García-Rodríguez 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第9期1519-1521,共3页
Our common home,planet Earth,is inhabited by more than 7 billion human beings.The average life expectancy currently estimated for men is^69 years,with strong differences among countries.Currently,neurodegenerative dis... Our common home,planet Earth,is inhabited by more than 7 billion human beings.The average life expectancy currently estimated for men is^69 years,with strong differences among countries.Currently,neurodegenerative diseases are currently the leading cause of death and disability worldwide.In clinical use and neuroscience research,a solution for an effective diagnosis is in progress,but a prophylactic treatment to counteract this long-lasting plague for humanity is still unidentified. 展开更多
关键词 OUR common HOME NEURODEGENERATIVE STILL unidentified
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Sigma-1 receptor: culprit and rescuer in motor neuron diseases
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作者 Jean-Charles Liévens tangui maurice 《Neural Regeneration Research》 SCIE CAS CSCD 2021年第1期106-107,共2页
Initially,the Sigma-1 receptor(S1R)was incorrectly categorized as one of the opioid receptors.But it has since become clear that S1R is a non-opioid non-phencyclidine receptor with molecular chaperone activity.S1R is ... Initially,the Sigma-1 receptor(S1R)was incorrectly categorized as one of the opioid receptors.But it has since become clear that S1R is a non-opioid non-phencyclidine receptor with molecular chaperone activity.S1R is a 223 amino-acid long protein that shares no clear homology with any other known mammalian proteins,its closest homolog being the fungal ERG2 sterol isomerase.Even its pharmacological counterpart,the Sigma-2 receptor that was only recently cloned,is genetically distinct.S1R is more likely considered as an atypical ligand-modulated chaperone protein.S1R is widely expressed in many organs including brain where its function has mainly been explored. 展开更多
关键词 ORGANS OPIOID SIGMA
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Amylovis-201 is a new dual-target ligand,acting as an anti-amyloidogenic compound and a potent agonist of theσ1 chaperone protein
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作者 Laura Garcia-Pupo Lucie Crouzier +7 位作者 Alberto Bencomo-Martinez Johann Meunier Axelle Morilleau Benjamin Delprat Marquiza Sablon Carrazana Roberto Menendez Soto del Valle tangui maurice Chryslaine Rodriguez-Tanty 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2024年第10期4345-4359,共15页
The aggregation of Amyloid-β(Aβ)peptides is associated with neurodegeneration in Alzheimer's disease(AD).We previously identified novel naphtalene derivatives,including the lead compound Amylovis-201,able to for... The aggregation of Amyloid-β(Aβ)peptides is associated with neurodegeneration in Alzheimer's disease(AD).We previously identified novel naphtalene derivatives,including the lead compound Amylovis-201,able to form thermodynamically stable complexes with Aβspecies,peptides and fibrils.As the drug showed a chemical scaffold coherent for an effective interaction with theσ_(1) receptor chaperone and asσ_(1) agonists are currently developed as potent neuroprotectants in AD,we investigated the pharmacological action of Amylovis-201 on theσ_(1) receptor.We report that Amylovis-201 is a potentσ_(1) agonist by several in silico,in vitro and in vivo assays and that its anti-amnesic and neuroprotective effects involve a pharmacological action atσ_(1) receptors.Furthermore,we show for the first time that classicalσ_(1) receptor agonist(PRE-084),and antagonist(NE-100)are able to interact and disaggregate Aβ_(25-35) fibrils.Interestingly,Amylovis-201 was the only compound inhibiting Aβ_(25-35) aggregates formation.Our results therefore highlight a dual action of Amylovis-201 as anti-aggregating agent andσ_(1) receptor agonist that could be highly effective in long-term treatment against neurodegeneration in AD. 展开更多
关键词 Alzheimer’s disease Amyloid-b aggregation Neuroprotection s1 receptor Drug discovery Molecular modelisation Zebrafish model Learning and memory
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