To the Editor,Sarcoidosis is a disease known for over a century and remains enigmatic in etiology and pathophysiology.1 While the pulmonary manifestation prevails in more than 90%of cases,sarcoidosis can affect any or...To the Editor,Sarcoidosis is a disease known for over a century and remains enigmatic in etiology and pathophysiology.1 While the pulmonary manifestation prevails in more than 90%of cases,sarcoidosis can affect any organ.Commonly,it targets the eyes,skin,lymph nodes,and,in rare instances,the liver and spleen.2 The development of the disease is significantly influenced by genetic and environmental factors,as well as gene variations on chromosome 6.Notably,first-degree relatives of patients have a heightened risk factor of 3.7.Other adverse prognostic factors involve being of Black race,female gender,and having a lower income.The increased incidence of sarcoidosis among firefighters who responded to the 9/11 disaster highlighted environmental triggers,including agricultural employment,metalworking,firefighting,exposure to inorganic and silica dust,and handling building supplies.1 Clinical symptoms can vary widely depending on the affected organ.Diagnosis often relies on characteristic chest radiography findings,but approximately 10%of patients show noncaseating granulomas on biopsy without pulmonary abnormalities.2 Herein,we present a unique case of multiorgan sarcoidosis,where the sole manifestations were severe thrombocytopenia,weight loss,and a history of cerebral vascular events.展开更多
文摘To the Editor,Sarcoidosis is a disease known for over a century and remains enigmatic in etiology and pathophysiology.1 While the pulmonary manifestation prevails in more than 90%of cases,sarcoidosis can affect any organ.Commonly,it targets the eyes,skin,lymph nodes,and,in rare instances,the liver and spleen.2 The development of the disease is significantly influenced by genetic and environmental factors,as well as gene variations on chromosome 6.Notably,first-degree relatives of patients have a heightened risk factor of 3.7.Other adverse prognostic factors involve being of Black race,female gender,and having a lower income.The increased incidence of sarcoidosis among firefighters who responded to the 9/11 disaster highlighted environmental triggers,including agricultural employment,metalworking,firefighting,exposure to inorganic and silica dust,and handling building supplies.1 Clinical symptoms can vary widely depending on the affected organ.Diagnosis often relies on characteristic chest radiography findings,but approximately 10%of patients show noncaseating granulomas on biopsy without pulmonary abnormalities.2 Herein,we present a unique case of multiorgan sarcoidosis,where the sole manifestations were severe thrombocytopenia,weight loss,and a history of cerebral vascular events.
