Incidence of colorectal cancer(CRC)is on rise.While approximately 70%of all CRC cases are sporadic in nature,20%-25%have familial aggregation and only<5%is hereditary in origin.Identification of individuals with he...Incidence of colorectal cancer(CRC)is on rise.While approximately 70%of all CRC cases are sporadic in nature,20%-25%have familial aggregation and only<5%is hereditary in origin.Identification of individuals with hereditary predilection for CRC is critical,as it has an impact on their overall surgical management including surgical timing,approach&technique and determines the role of prophylactic surgery and outcome.This review highlights the concept of hereditary CRC,provides insight into its molecular basis,possibility of its application into clinical practice and emphasizes the current treatment strategies with surgical management,based on the available international guidelines.展开更多
Parenting children of opposite genders is a powerful motive for parents to seek “sex-selection” services. Medical beneficence and patient autonomy support making these services available. Our goals in this study inc...Parenting children of opposite genders is a powerful motive for parents to seek “sex-selection” services. Medical beneficence and patient autonomy support making these services available. Our goals in this study included data to permit proper patient education, assess outcome, and evaluation of potential biases in this technology. IVF/PGD cases from August 2004 to December 2009 were studied (n = 122). FISH was used to analyze nuclear DNA of biopsied embryos. The variables analyzed were patient age, Day 3 Fluorescent In Situ Hybridization (FISH), the number of fertilized embryos, the number of embryos biopsied, Preimplantation Genetic Diagnosis (PGD) results, the number of embryos transferred, and the fate of remaining embryos. Female embryos were sought in 84 cycles, and male embryos desired in 38 cycles. Couples seeking female offspring had a reduced likelihood of a female-only transfer vs. those seeking males (p < 0.001). No transfer was performed in 32 cases for lack of normal embryos of desired gender. Clinical pregnancy rate per embryo transfer was 30.4%. PGD success rates for gender variety were lower than expected comparative to traditional IVF. In this report we present our clinical experience with IVF/PGD for gender selection. We attempt to analyze which patients seek this specialized treatment and to provide direct clinical and laboratory outcome data from our completed cycles.展开更多
文摘Incidence of colorectal cancer(CRC)is on rise.While approximately 70%of all CRC cases are sporadic in nature,20%-25%have familial aggregation and only<5%is hereditary in origin.Identification of individuals with hereditary predilection for CRC is critical,as it has an impact on their overall surgical management including surgical timing,approach&technique and determines the role of prophylactic surgery and outcome.This review highlights the concept of hereditary CRC,provides insight into its molecular basis,possibility of its application into clinical practice and emphasizes the current treatment strategies with surgical management,based on the available international guidelines.
文摘Parenting children of opposite genders is a powerful motive for parents to seek “sex-selection” services. Medical beneficence and patient autonomy support making these services available. Our goals in this study included data to permit proper patient education, assess outcome, and evaluation of potential biases in this technology. IVF/PGD cases from August 2004 to December 2009 were studied (n = 122). FISH was used to analyze nuclear DNA of biopsied embryos. The variables analyzed were patient age, Day 3 Fluorescent In Situ Hybridization (FISH), the number of fertilized embryos, the number of embryos biopsied, Preimplantation Genetic Diagnosis (PGD) results, the number of embryos transferred, and the fate of remaining embryos. Female embryos were sought in 84 cycles, and male embryos desired in 38 cycles. Couples seeking female offspring had a reduced likelihood of a female-only transfer vs. those seeking males (p < 0.001). No transfer was performed in 32 cases for lack of normal embryos of desired gender. Clinical pregnancy rate per embryo transfer was 30.4%. PGD success rates for gender variety were lower than expected comparative to traditional IVF. In this report we present our clinical experience with IVF/PGD for gender selection. We attempt to analyze which patients seek this specialized treatment and to provide direct clinical and laboratory outcome data from our completed cycles.
