菜籽粕的营养价值及其在猪生产中的应用研究进展

开发与利用非常规蛋白质饲料资源用于减量替代生猪饲粮中的豆粕是当下生猪产业中的重点和难点。菜籽粕是油菜籽榨油后的副产品,是世界上第二大类植物性蛋白质饲料资源,具有粗蛋白质含量高、氨基酸均衡、产量高和成本低等优点,其作为蛋白质原料替代猪饲粮中的豆粕具有广阔的应用前景。但是,因菜籽粕抗营养因子的存在限制了其在猪饲粮中的应用。本文介绍了菜籽粕的营养价值,并阐述了提高菜籽粕饲用价值的生物学方法及其在猪生产中的应用研究进展,以期为生猪饲粮中豆粕减量替代提供参考。

基于弹簧—阻尼理论的海上变电站动力特性研究

近年来,随着海上风电的迅速发展,海上变电站的建设也逐渐兴起。然而,错综复杂、瞬息万变的海洋环境对变电站的安全性和稳定性提出了严峻的挑战,因此有必要加强对变电站分析和研究的重视。为了提高变电站数值模型分析的效率,研究以海上风电场变电站为中心,采用ABAQUS建立了实体土有限元模型和基于弹簧—阻尼理论的有限元模型,以模拟桩土相互作用。随后进行了模态分析、风浪流响应分析和地震响应分析研究。研究结果表明:使用两种模型进行模态分析得出的振型非常相似,频率误差小于5%。此外,在承受风和波流荷载时,两种模型得出的变电站结构响应具有显著的一致性。在地震荷载作用下,两个模型中样本点位移时程曲线的相位频率与测量数据非常接近。值得注意的是,基于弹簧—阻尼理论的模型计算出的振幅与地震波测量数据更为接近。此外,弹簧—阻尼理论方法还大大提高了计算效率。

The FAST Core Array

The Five-hundred-meter Aperture Spherical Radio Telescope(FAST)Core Array is a proposed extension of FAST,integrating 24 secondary 40-m antennas implanted within 5 km of the FAST site.This original array design will combine the unprecedented sensitivity of FAST with a high angular resolution(4.3"at a frequency of 1.4 GHz),thereby exceeding the capabilities at similar frequencies of next-generation arrays such as the Square Kilometre Array Phase 1 or the next-generation Very Large Array.This article presents the technical specifications of the FAST Core Array,evaluates its potential relatively to existing radio telescope arrays,and describes its expected scientific prospects.The proposed array will be equipped with technologically advanced backend devices,such as real-time signal processing systems.A phased array feed receiver will be mounted on FAST to improve the survey efficiency of the FAST Core Array,whose broad frequency coverage and large field of view(FOV)will be essential to study transient cosmic phenomena such as fast radio bursts and gravitational wave events,to conduct surveys and resolve structures in neutral hydrogen galaxies,to monitor or detect pulsars,and to investigate exoplanetary systems.Finally,the FAST Core Array can strengthen China's major role in the global radio astronomy community,owing to a wide range of potential scientific applications from cosmology to exoplanet science.

Realizing photomultiplication-type organic photodetectors based on C_(60)-doped bulk heterojunction structure at low bias

Photomultiplication(PM) structure has been widely employed to improve the optoelectronic performance of organic photodetectors(OPDs). However, most PM-type OPDs require a high negative operating voltage or complex fabrication. For obtaining high-efficiency OPDs with low voltage and easy process, here the bulk heterojunction(BHJ) structure of high exciton dissociation efficiency combined with the method of trap-assisted PM are applied to the OPDs.In this paper, we investigate the operating mechanism of OPDs based on poly(3-hexylthiophene)(P3 HT):(phenyl-C61-butyric-acid-methyl-ester)(PC61 BM), and poly-{[4,8-bis[(2-ethylhexyl)oxy]-benzo[1,2-b:4,5-b]dithiophene-2,6-diyl]-alt-[3-fluore-2-(octyloxy)carbonyl-thieno[3,4-b]thiophene-4,6-diyl]}(PBDT-TT-F):PC_(61)BM doped with C_(60) as active layer.Furthermore, the influence of C_(60) concentration on the optoelectronic performances is also discussed. With 1.6 wt.% C_(60)added, the P3 HT:PC_(61)BM:C_(60) OPD exhibits a 327.5% external quantum efficiency, a 1.21 A·W^(-1) responsivity, and a4.22 x 1012 Jones normalized detectivity at-1 V under 460 nm(0.21 mW·cm^(-2)) illumination. The experimental results show that the effective electron traps can be formed by doping a small weight of C_(60) into BHJ active layer. Thus the PM-type OPDs can be realized, which benefits from the cathode hole tunneling injection assisted by the trapped electrons in C_(60) near the A1 side. The efficiency of PM is related to the C_(60) concentration. The present study provides theoretical basis and method for the design of highly sensitive OPDs with low operating voltage and facile fabrication.

Periodic radio variability in NRAO 530:phase dispersion minimization analysis

A periodicity analysis of the radio light curves of the blazar NRAO 530 at 14.5, 8.0, and 4.8 GHz is presented employing an improved phase dispersion mini- mization technique. The result, which shows two persistent periodic components of 6 and ~ 10 yr at all three frequencies, is consistent with the results obtained with the Lomb-Scargle periodogram and weighted wavelet Z-transform algorithms. The reliability of the derived periodicities is confirmed by the Monte Carlo numerical sim- ulations which show a high statistical confidence. （Quasi-）Periodic fluctuations of the radio luminosity of NRAO 530 might be associated with the oscillations of the accre- tion disk triggered by hydrodynamic instabilities of the accreted flow.

Secondary lymphoma develops in the setting of heart failure when treating breast cancer: A case report

BACKGROUND Cardiovascular side effects occur frequently during anti-cancer treatment, and there is a growing concern that they may lead to premature morbidity and death. CASE SUMMARY A 32-year-old woman was diagnosed with breast cancer. After comprehensive treatment with neoadjuvant chemotherapy, surgery, postoperative adjuvant chemotherapy, postoperative adjuvant radiotherapy, and endocrine therapy, her breast cancer was cured. However, heart failure associated with anti-cancer treatment presented, most probably related to chemotherapy containing anthracycline. After active treatment, her cardiac function returned to normal. Unfortunately, follow-up visits revealed a second primary malignancy, lymphoma. After multiple courses of chemotherapy combined with targeted therapy, her lymphoma acquired complete remission and no cardiotoxicity was observed again. Heart failure related to breast treatment may be reversible. CONCLUSION Using alternatives to anthracycline in patients with lymphoma who are at risk of cardiac failure may preserve cardiac function.

Unraveling the electrocatalytically active sites and stability of Co&Co oxides on nanocarbon for oxygen evolution reaction in acid solution

The oxygen evolution reaction(OER)in acid solution is a significant challenge for non-precious metal electrocatalysts based on the transition metals although they have shown good OER performance in alkaline solution.In this study,we synthesized the electrocatalysts containing two or three Co species(Co,CoO and Co3O4)nanoparticles on porous graphitic carbon(PGC)nanosheets which were prepared by a facile and low-cost synthesis where Co(NO3)2•6H2O and glucose were pyrolyzed in the presence of sodium chloride template.The Co3O4-dominated catalyst as-prepared,Co3O4/PGC,is OER active in acid solution(1.74 V at a current density of 10 mA cm^−2).We identified the OER active sites in the catalyst to be the Co3O4 nanoparticles rather than carbon-coated Co.Through comparative studies of the varied catalysts,we also proved that Co3O4 is catalytically more active than Co and CoO.The Co3O4/PGC catalyst,however,lost almost of all its activity after 100 voltammetric cycles in the 1.2-1.8 V voltage window.When the catalyst stability was examined potentiostatically at different potentials,the catalyst showed good stability at 1.4 V.The stability study also revealed the mechanism of the catalyst instability in acid was caused by Co3O4 reduction below 1.4 V and by Co3O4 oxidation above 1.4 V.1.4 V is therefore a unique potential where Co3O4 nanoparticles are neither oxidized nor reduced to be susceptible to acid dissolution.

East Asian VLBI Network observations of active galactic nuclei jets:imaging with KaVA+Tianma+Nanshan

The East Asian Very Long Baseline Interferometry(VLBI) Network(EAVN) is a rapidly evolving international VLBI array that is currently promoted under joint efforts among China,Japan and Korea.EAVN aims at forming a joint VLBI Network by combining a large number of radio telescopes distributed over East Asian regions.After the combination of the Korean VLBI Network(KVN) and the VLBI Exploration of Radio Astrometry(VERA) into Ka VA,further expansion with the joint array in East Asia is actively promoted.Here we report the first imaging results(at 22 and 43 GHz) of bright radio sources obtained with Ka VA connected to Tianma 65-m and Nanshan 26-m Radio Telescopes in China.To test the EAVN imaging performance for different sources,we observed four active galactic nuclei(AGN) having different brightness and morphology.As a result,we confirmed that the Tianma 65-m Radio Telescope(TMRT) significantly enhances the overall array sensitivity,a factor of 4 improvement in baseline sensitivity and 2 in image dynamic range compared to the case of Ka VA only.The addition of the Nanshan 26-m Radio Telescope(NSRT) further doubled the east-west angular resolution.With the resulting high-dynamic-range,high-resolution images with EAVN(Ka VA+TMRT+NSRT),various fine-scale structures in our targets,such as the counter-jet in M87,a kink-like morphology of the 3 C 273 jet and the weak emission in other sources are successfully detected.This demonstrates the powerful capability of EAVN to study AGN jets and to achieve other science goals in general.Ongoing expansion of EAVN will further enhance the angular resolution,detection sensitivity and frequency coverage of the network.

Clumpy metal concentrations in elliptical galaxies NGC 4374 and NGC 4636

We present a high spatial resolution study of metal distributions in the nearby, gas-rich elliptical galaxies NGC 4374 and NGC 4636 with the Chandra ACIS archive data. We define the hardness ratio HRFeL as the ratio of the emission in 0.65- 1.4 keV to that in 0.3-0.6 keV and 1.4-3.5 keV （after the magnesium and silicon lines are excluded）, and HRcont as the ratio of the emission in 1.4-3.5keV to that in 0.3- 0.6 keV, so that the HRFeL and HRcont maps can be used to trace the iron abundance and gas temperature distributions, respectively. By applying the a Trous wavelet algorithm to the obtained emission hardness ratio maps, we reveal that the HRFeL distributions are highly irregular, exhibiting strong spatial variations on 0.1-1 Re scales, which do not follow the HRcont distributions. Since the effect of temperature variation is small, we conclude that most of the high-HRFeL regions are very likely to possess higher abundances than the ambient gas. We also find that these high-HRFeL substructures are not associated with either the LMXB or globular cluster populations, thus their origins should be related to AGN activity or mergers.

The jet of FSRQ PKS 1229-02 and its misidentification as a γ-ray AGN

Flat-spectrum radio quasar PKS 1229-02 with a knotty and asymmetric radio morphology was identified as the optical and radio counterpart of a γ-ray source. In this paper, we study the properties(e.g.morphology, opacity, polarization and kinematics) of the jet in PKS 1229-02 using radio interferometry.With our results, we find that the knotty and asymmetric morphology of this source may probably shaped by the interaction between its anterograde jet and the nonuniform dense ambient medium. By reproducing a Spectral Energy Distribution of PKS 1229-02 with the obtained kinematic parameters, we find that the relativistic beaming effect in PKS 1229-02 is not strong enough to produce the reported γ-ray emission,i.e. PKS 1229-02 may not be a γ-ray AGN. The misidentification may probably be due to the poor spatial resolution of the γ-ray detector of the previous generation.

e-VLBI observations of GRB 080409 afterglow with an Australasian radio telescope network

Transcontinental e-VLBI observations were conducted in June 2008 with telescopes in Australia, China and Japan. Detections were made of the radio-loud quasar PKS B0727-115, which shows superlu- minal motion, and the intra-day variable quasar PKS B0524＋034. The latter source was used as a phase reference calibrator for observations at the position of the gamma-ray burst GRB 080409, for which an upper limit to the radio emission is set. Australia Telescope Compact Array data were also used to derive a limit on the radio flux density of the GRB afterglow. These observations demonstrate the capability to form a large Australasian radio telescope network for e-VLBI, with data transported and processed in realtime over high capacity networks. This campaign represents the first step towards more regular e-VLBI observations in this region.

Group-scale asymmetric abundance structures in the NGC 533 group

By performing a two dimensional spectral analysis on the galaxy group NGC 533 with high-quality Chandra data, we find that the metal abundance distribution in this group is anisotropic. In the area around 2.5′ from the center, we find two concentrations of high abundance structures, in which the abundances are significantly higher than their surrounding regions at the 90% confidence level. We find that the total iron mass in these two regions agrees with the iron mass synthesized in the central dominant galaxy in n 19＋0.08 Gyr. The double-sided configuration of the high abun- 0.03 dance structure, together with the point-like radio emission in the center suggests that the abundance structures could have been transported from the center to their present positions by active galactic nucleus （AGN） activity. We further calculate the energy required for transport, and find that it could have been supplied during an AGN period. However, considering that this group is reported to have experienced a recent merger, the possibility that this merger is responsible for the abundance structures still cannot be excluded.

HPMW与垂直发射武器协同作战火力冲突判定研究

高功率微波(HPM)的舰载应用已成为未来舰艇武器发展的必然趋势,在协同防空作战中为了将HPM武器(HPMW)的作战优势最大化,研究其协同作战火力冲突及其判定方法具有重要意义。针对舰载HPM与垂直发射武器的火力冲突问题,从HPM发射特点及其对目标毁伤与干扰机理角度,采用HPM在传输过程中微波密度呈现的高斯分布效应的原理,选择微波对目标的毁伤阈值作为主要判断依据来建立HPMW危界模型;从扰动因素的角度将垂直发射武器的危界模型分为垂直上升段和转弯段,借助蒙特卡洛数值分析方法计算垂直发射武器危界模型安全阈值;描述了在协同防空作战中基于弹道预测下理想弹道与HPMW天线轴线的最短距离,通过设定的安全阈值与最短距离的关系来判断是否发生火力冲突。仿真结果表明,该模型较为准确地描述了HPMW的危界,减少了可射击空域的损失,能够有效地给出较为可靠的冲突告警信号。

淋巴瘤治疗相关的心血管并发症研究

目的:分析淋巴瘤患者治疗相关的心血管并发症及其对预后的影响。方法:回顾性分析北京大学肿瘤医院1995年1月至2017年12月期间收治的淋巴瘤患者的病历资料。收集患者在淋巴瘤治疗过程中和随访期间出现的心血管并发症,并采用Ka?plan-Meier法进行生存分析。结果:1173例淋巴瘤患者中男性742例(63.3%),女性431例(36.7%)。中位年龄为56(8~92)岁。霍奇金淋巴瘤77例(6.6%),非霍奇金淋巴瘤1095例(93.4%),病理分类不明确1例。发生治疗相关的心血管并发症137例(11.7%),包括:心律失常54例、血栓栓塞性疾病44例、心功能不全/心力衰竭15例、冠心病9例、周围血管病和脑卒中7例、高血压2例、肺动脉高压1例、心包疾病及其他5例。霍奇金淋巴瘤与非霍奇金淋巴瘤患者血管并发症的发生率无显著性差异(9.1%vs.11.9%,P=0.463)。104例(8.9%)患者因为心血管并发症导致原定抗肿瘤治疗方案的调整。发生心血管并发症患者的中位生存期与未发生心血管并发症患者相比无显著性差异(25.0个月vs.20.0个月,P=0.135)。结论:心血管并发症是淋巴瘤治疗相关的常见并发症,其中以心律失常和血栓栓塞性疾病为主。淋巴瘤治疗相关的心血管并发症对患者的预后无明显不良影响。

肺癌靶向治疗药物的心血管毒性

肺癌靶向治疗相关的心血管毒性并不少见。心律失常可能是肺癌靶向治疗中最突出的心血管毒性,其中以QT间期延长的危害最大。在接受奥希替尼和间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)抑制剂治疗的患者中,需特别警惕QT间期延长。高血压是抗血管内皮生长因子(vascular endothelial growth factor,VEGF)治疗和第三代ALK抑制剂中需关注的心血管毒性。针对HER-2靶向药物的心血管毒性相对较小。在接受MET抑制剂和ROS-1抑制剂患者中周围性水肿的发生率较高。临床治疗时需提高警惕,注意监测和处理靶向治疗中的各种心血管并发症。

直播电商消费者消费行为产生机制研究——基于双渠道影响视角

直播电商是数字化时代企业营销最新发展趋势。基于507份有效问卷,以S-O-R理论为框架,构建包含场景氛围和主播专业能力为自变量的双路径研究模型,采用层级回归分析法进行假设验证。结果表明:场景氛围和主播专业能力对消费者的信任感知和消费行为均有显著正向影响;信任感知对消费行为有显著正向影响;从众行为在信任感知和消费行为间起正向调节作用,并会强化信任感的中介效应。因此,企业应通过场景氛围营造和主播专业能力培养,提升消费者信任感知,并在倡导理性消费和传递企业价值主张的同时,适当利用从众行为,以提升企业营销效果和消费者决策效率。

风、浪、流荷载联合作用下海上升压站结构动力响应研究

台风作用引起的极端荷载对海上升压站的安全性构成了极大的威胁。基于有限元软件建立海上升压站计算模型,采用线性滤波法的AR模型模拟脉动风,采用线性波浪叠加法及改进的JONSWAP谱模拟随机波浪场,研究了结构的自振特性和风、浪、流荷载作用下结构的动力响应特性。结果表明:海上升压站结构的各阶自振频率均不在共振频率影响区域,可以保证结构不会与波浪发生共振;结构的响应随着波浪重现期或者台风风级的增大而增大,风荷载是海上升压站结构的主控荷载;风、浪、流荷载联合垂直作用于结构轴面时,会产生极端应力、位移响应,结构设计时应当在支撑柱交接部位进行加强处理。

Different prognostic association of systolic blood pressure at different time points with postdischarge events in patients hospitalized for decompensated heart failure

Background The association of systolic blood pressure(SBP) with mortality in heart failure(HF) patients is paradoxical, and the time points of baseline SBP are also different across prior studies. We hypothesized that the levels of SBP at admission and at discharge had different associations with postdischarge events. Methods The study population included patients hospitalized for decompensated HF in the Heart Failure Center of Fuwai Hospital from January 1, 2009 to December 31, 2014. The primary outcome was a composite of cardiovascular(CV) death and heart transplantation. Multivariate Cox proportional-hazards and restricted cubic spline analyses were used to assess the relationships between SBP at different time points and outcomes. Results In total, 2005 patients were included with a median follow-up of 48.4 months. The median age was 59 years, and 69.9% were male. Multivariate Cox analyses showed that compared with SBP < 105 mm Hg, higher SBP at admission was associated with better long-term primary outcome(105–119 mm Hg, HR = 0.764, P = 0.005;120-134 mm Hg, HR = 0.658, P < 0.001;≥ 135 mm Hg, HR = 0.657, P = 0.001). Patients whose discharge SBP was higher than 135 mm Hg had a similar primary outcome as those with SBP < 105 mm Hg(HR = 0.969, P = 0.867), and the results remained unchanged even after adjusting for admission SBP(HR = 1.235, P = 0.291). The results of restricted cubic spline analysis indicated similar associations. Conclusions Lower but not higher SBP at admission is associated with more CV deaths/heart transplantations(a reverse J-shaped curve). In contrast, there is a U-shaped association between discharge SBP and CV mortality/heart transplantation.

台风作用下海上升压站上部结构受力特征

以某海上风电项目场区内220 kV海上升压站结构为例,通过采用shell单元模拟支撑柱、beam单元模拟梁柱构件建立整体有限元数值模型进行仿真计算,对比分析了台风作用下海上升压站结构的受力特征:结构在二层、顶层边缘、直升机平台及附近顶层边缘位移普遍较大,重力作用导致升压站结构竖向变形明显,而受风方向的变形相对较小;结构每一层支撑柱表面与H型钢交接处局部应力明显较大,其余部位普遍较小。