The main treatments for Parkinson’s disease(PD)currently include surgery,rehabilitation,and most commonly,drug therapy.However,the drugs that are currently used to treat PD provide only symptomatic relief and delayed...The main treatments for Parkinson’s disease(PD)currently include surgery,rehabilitation,and most commonly,drug therapy.However,the drugs that are currently used to treat PD provide only symptomatic relief and delayed disease progression but have no curative effect and cause many adverse reactions.When considering pathogenic factors and metabolic regulation,PD and type 2 diabetes have a high rate of comorbidity;this provides a theoretical basis for the treatment of PD with first-line antidiabetic drugs.Among these agents,metformin reduces neuronal damage in the brains of PD patients via neuroprotection and the inhibition of oxidative stress and inflammatory responses,thus providing a novel strategy for the clinical treatment of PD.Here,we present the current state of knowledge about the use of metformin to treat PD and discuss its clinical prospects.展开更多
基金This work was supported by the Natural Science Basic Research Plan in Shaanxi Province of China(No.2019JM-098,to JM)the National Natural Science Foundation of China(No.31371298,81301151,to JM)+1 种基金Opening Project of the Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,College of Stomatology,Xi’an Jiaotong University,China(No.2017LHM-KFKT007,to JM)the National Innovation Experiment Program for University Students(No.GJ201810698126,to JM).
文摘The main treatments for Parkinson’s disease(PD)currently include surgery,rehabilitation,and most commonly,drug therapy.However,the drugs that are currently used to treat PD provide only symptomatic relief and delayed disease progression but have no curative effect and cause many adverse reactions.When considering pathogenic factors and metabolic regulation,PD and type 2 diabetes have a high rate of comorbidity;this provides a theoretical basis for the treatment of PD with first-line antidiabetic drugs.Among these agents,metformin reduces neuronal damage in the brains of PD patients via neuroprotection and the inhibition of oxidative stress and inflammatory responses,thus providing a novel strategy for the clinical treatment of PD.Here,we present the current state of knowledge about the use of metformin to treat PD and discuss its clinical prospects.
