Value of myocardial function in children with Kawasaki disease by two-dimensional and three-dimensional ultrasound speckle tracking

Objective:To investigate the value of two-dimensional ultrasound speckle tracking(2D-STI)and three-dimensional ultrasound speckle tracking(3D-STI)in evaluating myocardial function in children with Kawasaki disease.Methods 92 children with Kawasaki disease admitted to our hospital from February 2017 to February 2019 were retrospectively analyzed.50 children who underwent 3D-STI examination were taken as observation group and 42 children who underwent 2D-STI examination were taken as control group.The left ventricular systolic function index,storage time and analysis time of the image,the diameter of coronary artery,the strain difference of left ventricular basal segment,middle segment,apical segment and whole segment were observed.Results The levels of left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),left ventricular myocardial mass(LVMI)in the observation group were higher than those in the control group(P<0.05),but there was no statistical difference in left ventricular ejection fraction(LVEF)between the two groups(P>0.05).The storage time and analysis time of the image in the observation group were significantly lower than those in the control group(P<0.05).The left coronary artery(LCA)and right coronary artery(RCA)in the observation group were higher than those in the control group(P<0.05).There was no statistical difference between left anterior descending(LAD)in the two groups(P>0.05).The longitudinal peak systolic strain(LS),circumferential peak systolic strain(CS)and radial peak systolic strain(RS)in the observation group were higher than those in the control group(P<0.05).The global longitudinal peak strain(GLS),global circumferential peak strain(GCS)and global radial peak strain(GRS)in the observation group were higher than those in the control group(P<0.05).LS and CS in the middle segment of the observation group were higher than those in the control group(P<0.05).Conclusions Compared with 2D-STI,3D-STI can objectively and accurately reflect the myocardial function of children with Kawasaki disease.

Expressions and significances of IFN-γ, IL-10, TGF-β, PFP and GNLY in serum of children with Henoch Schonlein purpura

Objective:To investigate the expressions of interferon-γ (IFN-γ), interleukin-10 (IL-10), transforming growth factor-β (TGF-β), perforin (PFP) and granulysin (GNLY) in serum of children with Henoch-Schonlein purpura (HSP) and their significances.Methods: 86 children with HSP admitted to our hospital from April 2016 to April 2018 were selected as the study subjects (HSP group), according to whether or not combined with renal injury, they were divided into kidney injury group (41 cases) and non-kidney injury group (45 cases), and 40 healthy children as the control group. The levels of serum IFN-γ, IL-10 and TGF-β were detected by enzyme-linked immunosorbent assay (ELISA), levels of serum PFP and GNLY were detected by RT-PCR, the differences between different groups were compared, the relationships between serum IFN-γ, IL-10, TGF-β, PFP and GNLY in group HSP was also analyzed.Results: The levels of serum IFN-γ, PFP and GNLY in HSP group were lower than those in control group (P<0.05), and the levels of serum IL-10 and TGF-β were higher than those in control group (P<0.05);the levels of serum IFN-γ, PFP and GNLY in renal injury group were lower than those in non-renal injury group (P<0.05), while the levels of serum IL-10 and TGF-β were higher than those in non-renal injury group (P<0.05);in HSP group, serum IFN-γ was negatively correlated with TGF-β (r=-0.417,P=0.037), and positively correlated with PFP and GNLY (r=0.508, 0.477,P=0.025, 0.030);there was a positive correlation between IL-10 and TGF-β (r=0.514,P=0.017).Conclusion: The changes of serum IFN-γ, IL-10, TGF-β, PFP and GNLY are closely related to the occurrence and progression of HSP, early detection is helpful to the evaluation of HSP and has guiding significance for clinical prevention of Henoch-Schonlein purpura nephritis.