Objective: To explore the effects of Xuefu Zhuyu Decoction combined with conventional therapy on inflammatory response, oxidative stress, endothelium and related factors in patients with acute cerebral infarction. Met...Objective: To explore the effects of Xuefu Zhuyu Decoction combined with conventional therapy on inflammatory response, oxidative stress, endothelium and related factors in patients with acute cerebral infarction. Methods: A total of 162 patients with acute cerebral infarction admitted to our hospital from November 2016 to January 1818 were selected as subjects. According to the random sampling method, the subjects were divided into 81 cases in the control group and 81 cases in the observation group. The control group was treated with conventional intracranial pressure, anticoagulation, anti-oxidation and lipid-lowering treatment. The observation group was treated with Xuefu Zhuyu Decoction on the basis of the control group. The changes of inflammatory response, oxidative stress, endothelium and related factors were compared and analyzed. Results:Before treatment, the levels of TNF-α, CRP, SOD, MDA, AOPPS, NO, ET-1, MMP-9, PAF and IGF-1 in the two groups were not significantly different, and there was no statistical significance. After treatment, the levels of TNF-α and CRP in the two groups were significantly lower than those before treatment, and the levels of TNF-α and CRP in the observation group were significantly lower than control group;the levels of MDA and AOPPS in the two groups were significantly lower than those before treatment, while the level of SOD was significantly higher than before treatment, and the levels of MDA and AOPPS in the observation group were significantly lower than control group, while the level of SOD was significantly higher. In the control group;the level of ET-1 in the two groups was significantly lower than that before treatment, while the level of NO was significantly higher than that before the treatment, and in the observation group the level of ET-1 was significantly lower than the control group, while the level of NO was significantly higher. In the control group;the levels of MMP-9 and PAF in the two groups were significantly lower than those before treatment, while the level of IGF-1 was significantly higher than before treatment, and the levels of MMP-9 and PAF in the observation group were significantly lower than control group, while the level of IGF-1 was significantly higher than control group. Conclusions: Xuefu Zhuyu Decoction combined with conventional treatment of acute cerebral infarction can effectively reduce inflammation and oxidative stress, improve vascular endothelial function and nerve function, and significantly reduce the degree of brain injury, which has clinical significance.展开更多
A polypseudorotaxane（PPR） nanoparticle was fabricated by the self-assembly of m PEG-protoporphyrin IX（PpIX） conjugate and a-CDs via the host-guest interaction.The nanoparticle loaded with anticancer drug doxorubi...A polypseudorotaxane（PPR） nanoparticle was fabricated by the self-assembly of m PEG-protoporphyrin IX（PpIX） conjugate and a-CDs via the host-guest interaction.The nanoparticle loaded with anticancer drug doxorubicin（DOX） exerted synergistic photodynamic and chemotherapy.The nanoparticle was spherical with the mean size of 89 nm,the low critical micelle concentration（CMC） of DOX-loaded nanoparticle was 9.3 mg/m L and the drug loading content was 9.93%.The in vitro anticancer activity test revealed that the DOX-loaded nanoparticle exhibited promising reactive oxygen species（ROS）cytotoxicity and chemotherapeutic efficacy to cancer cells.The PPR nanoparticle is potentially promising for synergistic photodynamic and chemotherapy for cancers.展开更多
文摘Objective: To explore the effects of Xuefu Zhuyu Decoction combined with conventional therapy on inflammatory response, oxidative stress, endothelium and related factors in patients with acute cerebral infarction. Methods: A total of 162 patients with acute cerebral infarction admitted to our hospital from November 2016 to January 1818 were selected as subjects. According to the random sampling method, the subjects were divided into 81 cases in the control group and 81 cases in the observation group. The control group was treated with conventional intracranial pressure, anticoagulation, anti-oxidation and lipid-lowering treatment. The observation group was treated with Xuefu Zhuyu Decoction on the basis of the control group. The changes of inflammatory response, oxidative stress, endothelium and related factors were compared and analyzed. Results:Before treatment, the levels of TNF-α, CRP, SOD, MDA, AOPPS, NO, ET-1, MMP-9, PAF and IGF-1 in the two groups were not significantly different, and there was no statistical significance. After treatment, the levels of TNF-α and CRP in the two groups were significantly lower than those before treatment, and the levels of TNF-α and CRP in the observation group were significantly lower than control group;the levels of MDA and AOPPS in the two groups were significantly lower than those before treatment, while the level of SOD was significantly higher than before treatment, and the levels of MDA and AOPPS in the observation group were significantly lower than control group, while the level of SOD was significantly higher. In the control group;the level of ET-1 in the two groups was significantly lower than that before treatment, while the level of NO was significantly higher than that before the treatment, and in the observation group the level of ET-1 was significantly lower than the control group, while the level of NO was significantly higher. In the control group;the levels of MMP-9 and PAF in the two groups were significantly lower than those before treatment, while the level of IGF-1 was significantly higher than before treatment, and the levels of MMP-9 and PAF in the observation group were significantly lower than control group, while the level of IGF-1 was significantly higher than control group. Conclusions: Xuefu Zhuyu Decoction combined with conventional treatment of acute cerebral infarction can effectively reduce inflammation and oxidative stress, improve vascular endothelial function and nerve function, and significantly reduce the degree of brain injury, which has clinical significance.
基金financial support of National Natural Science Foundation of China(No.51573111)Program for Changjiang Scholars and Innovative Research Team in University(No.IRT-15R48)
文摘A polypseudorotaxane（PPR） nanoparticle was fabricated by the self-assembly of m PEG-protoporphyrin IX（PpIX） conjugate and a-CDs via the host-guest interaction.The nanoparticle loaded with anticancer drug doxorubicin（DOX） exerted synergistic photodynamic and chemotherapy.The nanoparticle was spherical with the mean size of 89 nm,the low critical micelle concentration（CMC） of DOX-loaded nanoparticle was 9.3 mg/m L and the drug loading content was 9.93%.The in vitro anticancer activity test revealed that the DOX-loaded nanoparticle exhibited promising reactive oxygen species（ROS）cytotoxicity and chemotherapeutic efficacy to cancer cells.The PPR nanoparticle is potentially promising for synergistic photodynamic and chemotherapy for cancers.
