To the Editor:Biliary atresia(BA)is a rare obliterative cholangiopathy that occurs during infancy in association with destructive liver inflammation and hepatic fibrosis.Although recent studies have shown that transfo...To the Editor:Biliary atresia(BA)is a rare obliterative cholangiopathy that occurs during infancy in association with destructive liver inflammation and hepatic fibrosis.Although recent studies have shown that transforming growth factor-b(TGF-b)plays an important role in liver fibrosis and inflammation in BA,disease mechanisms remain poorly understood.Circular RNAs(circRNAs)are a recently discovered unique class of regulatory RNA molecules with high specificity.As previous evidence links circRNAs to the regulation of the TGF-b inflammatory signaling pathway,we further investigated the potential regulatory roles of circRNAs in BA and found novel insights into BA pathogenesis.展开更多
基金supported by Sanming Project of Medicine in Shenzhen(No.SZSM201812055)National Natural Science Foundation of China(No.81770512)Research topic on academic and postgraduate education in China(No.2020MSA126).
文摘To the Editor:Biliary atresia(BA)is a rare obliterative cholangiopathy that occurs during infancy in association with destructive liver inflammation and hepatic fibrosis.Although recent studies have shown that transforming growth factor-b(TGF-b)plays an important role in liver fibrosis and inflammation in BA,disease mechanisms remain poorly understood.Circular RNAs(circRNAs)are a recently discovered unique class of regulatory RNA molecules with high specificity.As previous evidence links circRNAs to the regulation of the TGF-b inflammatory signaling pathway,we further investigated the potential regulatory roles of circRNAs in BA and found novel insights into BA pathogenesis.
