Glioblastoma multiforme(GBM)is a debilitating disease that is associated with poor prognosis,short median patient survival and a very limited response to therapies.GBM has a very complex pathogenesis that involves mut...Glioblastoma multiforme(GBM)is a debilitating disease that is associated with poor prognosis,short median patient survival and a very limited response to therapies.GBM has a very complex pathogenesis that involves mutations and alterations of several key cellular pathways that are involved in cell proliferation,survival,migration and angiogenesis.Therefore,efforts that are directed toward better understanding of GBM pathogenesis are essential to the development of efficient therapies that provide hope and extent patient survival.In this review,we outline the alterations commonly associated with GBM pathogenesis and summarize therapeutic strategies that are aimed at targeting aberrant cellular pathways in GBM.展开更多
基金This work was supported by the John and Lucille van Geest Foundation,the John van Geest Cancer Research Centre(Nottingham Trent University)and the Headcase cancer trust.
文摘Glioblastoma multiforme(GBM)is a debilitating disease that is associated with poor prognosis,short median patient survival and a very limited response to therapies.GBM has a very complex pathogenesis that involves mutations and alterations of several key cellular pathways that are involved in cell proliferation,survival,migration and angiogenesis.Therefore,efforts that are directed toward better understanding of GBM pathogenesis are essential to the development of efficient therapies that provide hope and extent patient survival.In this review,we outline the alterations commonly associated with GBM pathogenesis and summarize therapeutic strategies that are aimed at targeting aberrant cellular pathways in GBM.
