Background: Brain abscess is defined as a focal intracranial infection that is initiated as an area of cerebritis and evolves into a collection of pus surrounded by a vascularized capsule. These are complications of h...Background: Brain abscess is defined as a focal intracranial infection that is initiated as an area of cerebritis and evolves into a collection of pus surrounded by a vascularized capsule. These are complications of head trauma, neurosurgical operations, meningitis, and otogenic, mastoid, and paranasal air sinus infections. Management involves both medical and surgical treatment. Surgical management includes either aspiration or excision of lesions larger than 2.5 cm in diameter, depending on brain location. However, literature on surgical treatment is replete with several procedures which, on their own, may not determine outcome. Aim: Aim is to study the epidemiology, management and outcome of various treatment modalities of brain abscess in our institute. Material and Methods: We conducted a retrospective study of demographic data as well as indications, treatment modalities, and outcomes of various surgical procedures for evacuation of intracranial abscesses in patients admitted to our Neuro-intensive care unit at R.N.T. Medical College, Udaipur, Rajasthan, India from January 2013 to June 2019. Results: We carried out 53 procedures in 43 (30 male and 13 female) patients with various intracranial abscesses. Most abscesses [16, i.e. 37%] occurred in the second decade and second most common in the first decade [15, i.e. 34%]. In infants 4 (9%) cases of intracranial abscesses were present. None of the infants had features of congenital heart disease. The predisposing factors were mostly otolaryngologic (15) or posttraumatic (8). Most commonly abscesses were located in frontal 13 (30%) followed by cerebellar 9 (21%). Burr hole evacuation was done in 74% of cases. 3 patients (7% of cases) died. Prognosis appears to worsen with ventriculitis, multiple abscesses especially in infants, and immunosuppression. Conclusion: In conclusion, brain abscess still continues to be a formidable challenge, with prognosis that dramatically improved over the last decades due to advances in brain imaging, neurosurgical techniques and better use of old and more recent antibacterial agents. Mortality is improved compared with historical series;however, long-term morbidity is significant particularly in the infant population. Further researches must be conducted to clarify specific aspects, such as anticonvulsant prophylaxis/therapy, and also for the improvement of microbiological diagnosis.展开更多
A new circuit technique for 65 nm technology is proposed in this paper for reducing the subthreshold and gate oxide leakage currents in idle and non idle mode of operation for footerless domino circuits. In this techn...A new circuit technique for 65 nm technology is proposed in this paper for reducing the subthreshold and gate oxide leakage currents in idle and non idle mode of operation for footerless domino circuits. In this technique a p-type and an n-type leakage controlled transistors (LCTs) are introduced between the pull-up and pull-down network and the gate of one is controlled by the source of the other. For any combination of input, one of the LCT will operate near its cut off region and will increase the resistance between supply voltage and ground resulting in reduced leakage current. Furthermore, the leakage current is suppressed at the output inverter circuit by inserting a transistor below the n-type transistor of the inverter offering more resistive path between supply voltage and ground. The proposed technique is applied on benchmark circuits reduction of active power consumption is observed from 10.9% to 44.76% at different temperature variations. For same benchmark circuits, operating at two clock modes and giving low and high inputs at 25℃ and 110℃ temperatures the maximum leakage power saving of 98.9% is achieved when compared to standard footerless domino logic circuits.展开更多
文摘Background: Brain abscess is defined as a focal intracranial infection that is initiated as an area of cerebritis and evolves into a collection of pus surrounded by a vascularized capsule. These are complications of head trauma, neurosurgical operations, meningitis, and otogenic, mastoid, and paranasal air sinus infections. Management involves both medical and surgical treatment. Surgical management includes either aspiration or excision of lesions larger than 2.5 cm in diameter, depending on brain location. However, literature on surgical treatment is replete with several procedures which, on their own, may not determine outcome. Aim: Aim is to study the epidemiology, management and outcome of various treatment modalities of brain abscess in our institute. Material and Methods: We conducted a retrospective study of demographic data as well as indications, treatment modalities, and outcomes of various surgical procedures for evacuation of intracranial abscesses in patients admitted to our Neuro-intensive care unit at R.N.T. Medical College, Udaipur, Rajasthan, India from January 2013 to June 2019. Results: We carried out 53 procedures in 43 (30 male and 13 female) patients with various intracranial abscesses. Most abscesses [16, i.e. 37%] occurred in the second decade and second most common in the first decade [15, i.e. 34%]. In infants 4 (9%) cases of intracranial abscesses were present. None of the infants had features of congenital heart disease. The predisposing factors were mostly otolaryngologic (15) or posttraumatic (8). Most commonly abscesses were located in frontal 13 (30%) followed by cerebellar 9 (21%). Burr hole evacuation was done in 74% of cases. 3 patients (7% of cases) died. Prognosis appears to worsen with ventriculitis, multiple abscesses especially in infants, and immunosuppression. Conclusion: In conclusion, brain abscess still continues to be a formidable challenge, with prognosis that dramatically improved over the last decades due to advances in brain imaging, neurosurgical techniques and better use of old and more recent antibacterial agents. Mortality is improved compared with historical series;however, long-term morbidity is significant particularly in the infant population. Further researches must be conducted to clarify specific aspects, such as anticonvulsant prophylaxis/therapy, and also for the improvement of microbiological diagnosis.
文摘A new circuit technique for 65 nm technology is proposed in this paper for reducing the subthreshold and gate oxide leakage currents in idle and non idle mode of operation for footerless domino circuits. In this technique a p-type and an n-type leakage controlled transistors (LCTs) are introduced between the pull-up and pull-down network and the gate of one is controlled by the source of the other. For any combination of input, one of the LCT will operate near its cut off region and will increase the resistance between supply voltage and ground resulting in reduced leakage current. Furthermore, the leakage current is suppressed at the output inverter circuit by inserting a transistor below the n-type transistor of the inverter offering more resistive path between supply voltage and ground. The proposed technique is applied on benchmark circuits reduction of active power consumption is observed from 10.9% to 44.76% at different temperature variations. For same benchmark circuits, operating at two clock modes and giving low and high inputs at 25℃ and 110℃ temperatures the maximum leakage power saving of 98.9% is achieved when compared to standard footerless domino logic circuits.
