Dear Editor,Chromosomal translocations result from the interchange of geneticmaterial between non-homologous chromosomes.Chromosomal translocations are formed by erroneous repair of double-stranded breaks(DSBs)via non...Dear Editor,Chromosomal translocations result from the interchange of geneticmaterial between non-homologous chromosomes.Chromosomal translocations are formed by erroneous repair of double-stranded breaks(DSBs)via non-homologous end joining(NHEJ)[1].Some genotoxic drugs produce DSBs and thus present a major risk factor for the development of oncogenic chromosomal translocations.The risk factors that interfere with translocationprone DSB repair,once DSBs are already formed,are obscure,and potential effects of drugs on translocation formation during this step have never been explored.展开更多
基金Cancéropole IdF,the Koltzov Institute of Developmental Biology,Russian Academy of Sciences Government basic research programs(0088-2021-0007)the Ministry of Science and Higher Education grants(075-15-2021-1075 to YV and 075-15-2021-1062 and 075-15-2021-1060 to MR)+1 种基金Russian Foundation for Basic Research(19-54-16002)the Interdisciplinary Scientific and Educational School of Moscow University≪Molecular Technologies of the Living Systems and Synthetic Biology≫to MR.AS was supported by the Travel Grant from Boehringer Ingelheim Fonds in 2018.
文摘Dear Editor,Chromosomal translocations result from the interchange of geneticmaterial between non-homologous chromosomes.Chromosomal translocations are formed by erroneous repair of double-stranded breaks(DSBs)via non-homologous end joining(NHEJ)[1].Some genotoxic drugs produce DSBs and thus present a major risk factor for the development of oncogenic chromosomal translocations.The risk factors that interfere with translocationprone DSB repair,once DSBs are already formed,are obscure,and potential effects of drugs on translocation formation during this step have never been explored.
