Pericytes are classically defined as contra ctile cells within the central nervous system that regulate blood flow and permeability of the blood-brain barrier(BBB).This one-sided view is gradually changing,and pericyt...Pericytes are classically defined as contra ctile cells within the central nervous system that regulate blood flow and permeability of the blood-brain barrier(BBB).This one-sided view is gradually changing,and pericytes are now considered versatile cells that can switch their function in response to different stimuli(Uemura et al.,2020).In addition to their role as gatekeepers of the BBB and maintaining homeostasis of the brain’s microenvironment through adj usting the vascular intraluminal dia meter,pericytes are both sensors and initiators of inflammation.展开更多
基金Neurological Foundation First Fellowship(2244 FFE)(to TJS)Health Research Council Hercus(21/034)+1 种基金a Neurologicalgrant(2026PRG)School of Medical Science,University of Auckland(to BVD)。
文摘Pericytes are classically defined as contra ctile cells within the central nervous system that regulate blood flow and permeability of the blood-brain barrier(BBB).This one-sided view is gradually changing,and pericytes are now considered versatile cells that can switch their function in response to different stimuli(Uemura et al.,2020).In addition to their role as gatekeepers of the BBB and maintaining homeostasis of the brain’s microenvironment through adj usting the vascular intraluminal dia meter,pericytes are both sensors and initiators of inflammation.
