The heterogeneous variational nodal method(HVNM)has emerged as a potential approach for solving high-fidelity neutron transport problems.However,achieving accurate results with HVNM in large-scale problems using high-...The heterogeneous variational nodal method(HVNM)has emerged as a potential approach for solving high-fidelity neutron transport problems.However,achieving accurate results with HVNM in large-scale problems using high-fidelity models has been challenging due to the prohibitive computational costs.This paper presents an efficient parallel algorithm tailored for HVNM based on the Message Passing Interface standard.The algorithm evenly distributes the response matrix sets among processors during the matrix formation process,thus enabling independent construction without communication.Once the formation tasks are completed,a collective operation merges and shares the matrix sets among the processors.For the solution process,the problem domain is decomposed into subdomains assigned to specific processors,and the red-black Gauss-Seidel iteration is employed within each subdomain to solve the response matrix equation.Point-to-point communication is conducted between adjacent subdomains to exchange data along the boundaries.The accuracy and efficiency of the parallel algorithm are verified using the KAIST and JRR-3 test cases.Numerical results obtained with multiple processors agree well with those obtained from Monte Carlo calculations.The parallelization of HVNM results in eigenvalue errors of 31 pcm/-90 pcm and fission rate RMS errors of 1.22%/0.66%,respectively,for the 3D KAIST problem and the 3D JRR-3 problem.In addition,the parallel algorithm significantly reduces computation time,with an efficiency of 68.51% using 36 processors in the KAIST problem and 77.14% using 144 processors in the JRR-3 problem.展开更多
A global variance reduction(GVR)method based on the SPN method is proposed.First,the global multi-group cross-sections are obtained by Monte Carlo(MC)global homogenization.Then,the SP3 equation is solved to obtain the...A global variance reduction(GVR)method based on the SPN method is proposed.First,the global multi-group cross-sections are obtained by Monte Carlo(MC)global homogenization.Then,the SP3 equation is solved to obtain the global flux distribution.Finally,the global weight windows are approximated by the global flux distribution,and the GVR simulation is performed.This GVR method is implemented as an automatic process in the RMC code.The SP3-coupled GVR method was tested on a modified version of C5 G7 benchmark with a thickened water shield.The results show that the SP3-coupled GVR method can improve the efficiency of MC criticality calculation.展开更多
Malignant tumors are still a worldwide threat to human health.Tumor treatment strategies are constantly evolving,and the advent of tumor immunotherapy has brought up hope to many types of tumors,especially for those t...Malignant tumors are still a worldwide threat to human health.Tumor treatment strategies are constantly evolving,and the advent of tumor immunotherapy has brought up hope to many types of tumors,especially for those that are refractory to conventional therapies including surgery,radiotherapy,and chemotherapy.Tumor vaccines can initiate or amplify an anti-tumor immune response in tumor patients through active immunization,and therefore occupy an important position in tumor immunotherapy.The main types of tumor vaccines include tumor cell vaccines,dendritic cell vaccines,polypeptide vaccines and nucleic acid vaccines.Due to factors such as poor antigen selection and suppressive tumor microenvironment,earliest tumor vaccines on clinical trials failed to achieve satisfactory clinical effects.However,with the development of second-generation genome sequencing technologies and bioinformatics tools,it is possible to predict neoantigens generated by tumor-specific mutations and therefore prepare personalized vaccines.This article summarizes the global efforts in developing tumor vaccines and highlights several representative tumor vaccines in each category.展开更多
Garnet-type solid-state batteries(SSBs)are considered to be one of the most promising candidates to realize next-generation lithium metal batteries with high energy density and safety.However,the dendrite-induced shor...Garnet-type solid-state batteries(SSBs)are considered to be one of the most promising candidates to realize next-generation lithium metal batteries with high energy density and safety.However,the dendrite-induced short-circuit and the poor interfacial contact impeded the practical application.Herein,interface engineering to achieve low interfacial resistance without high temperature calcination was developed,which Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO)was simply coated with complex hydride(Li_(4)(BH_(4))_(3)I(3L1L))in various mass ratios n(Li_(4)(BH_(4))_(3)I)-(100−n)LLZTO(10≤n≤40).The interfacial conductivity increases by more than three orders of magnitude from 8.29×10^(−6)S·cm^(−1)to 1.10×10^(−2)S·cm^(−1).Symmetric Li cells exhibit a high critical current density(CCD)of 4.0 mA·cm^(−2) and an excellent cycling stability for 200 h at 4.0 mA·cm^(−2).SSBs with polymeric sulfur-polyacrylonitrile(SPAN)cathode achieve a high discharge capacity of 1149 mAh·g^(−1) with a capacity retention of 91%after 100 cycles(0.2 C).This attempt guides a simple yet efficient strategy for obtaining a stable Li/LLZTO interface,which would promote the development of solid-state batteries.展开更多
In this study, AlTiN coatings were deposited on YT14 cemented carbide balls by arc ion plating technique. The friction and wear behavior of the AlTiN-coated balls against SKD11 hardened steel was investigated by slidi...In this study, AlTiN coatings were deposited on YT14 cemented carbide balls by arc ion plating technique. The friction and wear behavior of the AlTiN-coated balls against SKD11 hardened steel was investigated by sliding tests using a ball-ondisk tribometer at various temperatures from 25 to 700 ℃ in air. The results showed that the friction and wear behavior was significantly influenced by the testing temperature. Obvious fluctuations were observed in the friction curves at elevated temperatures, which could be attributed to the formation and rupture of unstable Fe and Cr oxide layers. As the temperature increased from 25 to 500 ~C, the wear rate of the coated balls increased from the scale of 10-21-10-20 m3/ N m, and then decreased to 10-22 m3/N m as the temperature further increased to 700℃. It was also found that the friction and wear behavior of the coated balls was directly dependent on the counterpart materials. As the temperature increased, the main wear mechanism of the coated balls changed from mild abrasive wear and adhesive wear to abrasive wear failure at 500℃, and then transferred to adhesive wear and mild oxidation wear at 700℃. For SKD11 hardened steel, the primary wear mechanism changed from delamination wear to abrasive wear and then transferred to plastic deformation and fatigue wear, accompanied by adhesive wear and tribo-oxidation wear.展开更多
基金supported by the National Key Research and Development Program of China(No.2020YFB1901900)the National Natural Science Foundation of China(Nos.U20B2011,12175138)the Shanghai Rising-Star Program。
文摘The heterogeneous variational nodal method(HVNM)has emerged as a potential approach for solving high-fidelity neutron transport problems.However,achieving accurate results with HVNM in large-scale problems using high-fidelity models has been challenging due to the prohibitive computational costs.This paper presents an efficient parallel algorithm tailored for HVNM based on the Message Passing Interface standard.The algorithm evenly distributes the response matrix sets among processors during the matrix formation process,thus enabling independent construction without communication.Once the formation tasks are completed,a collective operation merges and shares the matrix sets among the processors.For the solution process,the problem domain is decomposed into subdomains assigned to specific processors,and the red-black Gauss-Seidel iteration is employed within each subdomain to solve the response matrix equation.Point-to-point communication is conducted between adjacent subdomains to exchange data along the boundaries.The accuracy and efficiency of the parallel algorithm are verified using the KAIST and JRR-3 test cases.Numerical results obtained with multiple processors agree well with those obtained from Monte Carlo calculations.The parallelization of HVNM results in eigenvalue errors of 31 pcm/-90 pcm and fission rate RMS errors of 1.22%/0.66%,respectively,for the 3D KAIST problem and the 3D JRR-3 problem.In addition,the parallel algorithm significantly reduces computation time,with an efficiency of 68.51% using 36 processors in the KAIST problem and 77.14% using 144 processors in the JRR-3 problem.
基金Supported by the Shanghai Sailing Program,China(No.21YF1421100)the Startup Fund for Youngman Research at SJTU。
文摘A global variance reduction(GVR)method based on the SPN method is proposed.First,the global multi-group cross-sections are obtained by Monte Carlo(MC)global homogenization.Then,the SP3 equation is solved to obtain the global flux distribution.Finally,the global weight windows are approximated by the global flux distribution,and the GVR simulation is performed.This GVR method is implemented as an automatic process in the RMC code.The SP3-coupled GVR method was tested on a modified version of C5 G7 benchmark with a thickened water shield.The results show that the SP3-coupled GVR method can improve the efficiency of MC criticality calculation.
文摘Malignant tumors are still a worldwide threat to human health.Tumor treatment strategies are constantly evolving,and the advent of tumor immunotherapy has brought up hope to many types of tumors,especially for those that are refractory to conventional therapies including surgery,radiotherapy,and chemotherapy.Tumor vaccines can initiate or amplify an anti-tumor immune response in tumor patients through active immunization,and therefore occupy an important position in tumor immunotherapy.The main types of tumor vaccines include tumor cell vaccines,dendritic cell vaccines,polypeptide vaccines and nucleic acid vaccines.Due to factors such as poor antigen selection and suppressive tumor microenvironment,earliest tumor vaccines on clinical trials failed to achieve satisfactory clinical effects.However,with the development of second-generation genome sequencing technologies and bioinformatics tools,it is possible to predict neoantigens generated by tumor-specific mutations and therefore prepare personalized vaccines.This article summarizes the global efforts in developing tumor vaccines and highlights several representative tumor vaccines in each category.
基金This study was financially supported by the National Natural Science Foundation of China(Nos.52171180,51802154,and 51971065)the National Science Fund for Distinguished Young Scholars(No.51625102)+3 种基金the Innovation Program of Shanghai Municipal Education Commission(No.2019-01-07-00-07-E00028)the Fundamental Research Funds for the Central Universities(No.NG2022005)the Open Fund for Graduate Innovation Base in Nanjing University of Aeronautics and Astronautics(No.xcxjh20210612)partially supported by the Fundamental Research Funds for the Central Universities,NS2021043.
文摘Garnet-type solid-state batteries(SSBs)are considered to be one of the most promising candidates to realize next-generation lithium metal batteries with high energy density and safety.However,the dendrite-induced short-circuit and the poor interfacial contact impeded the practical application.Herein,interface engineering to achieve low interfacial resistance without high temperature calcination was developed,which Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO)was simply coated with complex hydride(Li_(4)(BH_(4))_(3)I(3L1L))in various mass ratios n(Li_(4)(BH_(4))_(3)I)-(100−n)LLZTO(10≤n≤40).The interfacial conductivity increases by more than three orders of magnitude from 8.29×10^(−6)S·cm^(−1)to 1.10×10^(−2)S·cm^(−1).Symmetric Li cells exhibit a high critical current density(CCD)of 4.0 mA·cm^(−2) and an excellent cycling stability for 200 h at 4.0 mA·cm^(−2).SSBs with polymeric sulfur-polyacrylonitrile(SPAN)cathode achieve a high discharge capacity of 1149 mAh·g^(−1) with a capacity retention of 91%after 100 cycles(0.2 C).This attempt guides a simple yet efficient strategy for obtaining a stable Li/LLZTO interface,which would promote the development of solid-state batteries.
基金supported in part by the projects of the National Natural Science Foundation of China(Grant No.51522502)the China Postdoctoral Science Foundation funded project(No.2016M600641)the Guangdong Natural Science Funds(Nos.2014A030311002 and 2016A050502056)
文摘In this study, AlTiN coatings were deposited on YT14 cemented carbide balls by arc ion plating technique. The friction and wear behavior of the AlTiN-coated balls against SKD11 hardened steel was investigated by sliding tests using a ball-ondisk tribometer at various temperatures from 25 to 700 ℃ in air. The results showed that the friction and wear behavior was significantly influenced by the testing temperature. Obvious fluctuations were observed in the friction curves at elevated temperatures, which could be attributed to the formation and rupture of unstable Fe and Cr oxide layers. As the temperature increased from 25 to 500 ~C, the wear rate of the coated balls increased from the scale of 10-21-10-20 m3/ N m, and then decreased to 10-22 m3/N m as the temperature further increased to 700℃. It was also found that the friction and wear behavior of the coated balls was directly dependent on the counterpart materials. As the temperature increased, the main wear mechanism of the coated balls changed from mild abrasive wear and adhesive wear to abrasive wear failure at 500℃, and then transferred to adhesive wear and mild oxidation wear at 700℃. For SKD11 hardened steel, the primary wear mechanism changed from delamination wear to abrasive wear and then transferred to plastic deformation and fatigue wear, accompanied by adhesive wear and tribo-oxidation wear.