Connectome mapping studies have documented a principal primary-to-transmodal gradient in the adult brain network,capturing a functional spectrum that ranges from perception and action to abstract cognition.However,how...Connectome mapping studies have documented a principal primary-to-transmodal gradient in the adult brain network,capturing a functional spectrum that ranges from perception and action to abstract cognition.However,how this gradient pattern develops and whether its development is linked to cognitive growth,topological reorganization,and gene expression profiles remain largely unknown.Using longitudinal resting-state functional magnetic resonance imaging data from 305 children(aged 6-14 years),we describe substantial changes in the primary-to-transmodal gradient between childhood and adolescence,including emergence as the principal gradient,expansion of global topography,and focal tuning in primary and default-mode regions.These gradient changes are mediated by developmental changes in network integration and segregation,and are associated with abstract processing functions such as working memory and expression levels of calcium ion regulated exocytosis and synaptic transmission-related genes.Our findings have implications for understanding connectome maturation principles in normal development and developmental disorders.展开更多
A dysbiosis in microbial diversity or functionality can promote disease development.Emerging preclinical and clinical evidence emphasizes the interplay between microbiota and both disease evolution and the treatment r...A dysbiosis in microbial diversity or functionality can promote disease development.Emerging preclinical and clinical evidence emphasizes the interplay between microbiota and both disease evolution and the treatment response of different cancers.One bacterium that has garnered much attention in a few cancer microbiota studies is Fusobacterium nucleaum(Fn).To provide updated knowledge of the functional role of Fn in cancer prevention and management,this review summarizes the relationship among Fn,cancer,and chemoimmunotherapy response,with the potential mechanisms of action also intensively discussed,which will benefit the development of strategies to prevent or treat cancer via Fn-based therapeutic interventions.展开更多
Main observation and conclusion Ring-opening metathesis polymerization(ROMP)is a powerful toolbox in preparation of bottlebrush polymers for its high activity.However,the ROMP of macromonomers with repeating tertiary ...Main observation and conclusion Ring-opening metathesis polymerization(ROMP)is a powerful toolbox in preparation of bottlebrush polymers for its high activity.However,the ROMP of macromonomers with repeating tertiary amine groups,for example,poly(2-(dimethylamino)ethyl methacrylate)(PDMAEMA).展开更多
基金supported by the National Natural Science Foundation of China(31830034,82021004,81620108016,31221003,31521063,81671767,82071998,81971690,32130045,and 61761166004)Changjiang Scholar Professorship Award(T2015027)+3 种基金the National Key Research and Development Project of China(2018YFA0701402)Beijing Nova Program(Z191100001119023)the Beijing Brain Initiative of Beijing Municipal Science&Technology Commission(Z181100001518003)the Fundamental Research Funds for the Central Universities(2020NTST29)。
文摘Connectome mapping studies have documented a principal primary-to-transmodal gradient in the adult brain network,capturing a functional spectrum that ranges from perception and action to abstract cognition.However,how this gradient pattern develops and whether its development is linked to cognitive growth,topological reorganization,and gene expression profiles remain largely unknown.Using longitudinal resting-state functional magnetic resonance imaging data from 305 children(aged 6-14 years),we describe substantial changes in the primary-to-transmodal gradient between childhood and adolescence,including emergence as the principal gradient,expansion of global topography,and focal tuning in primary and default-mode regions.These gradient changes are mediated by developmental changes in network integration and segregation,and are associated with abstract processing functions such as working memory and expression levels of calcium ion regulated exocytosis and synaptic transmission-related genes.Our findings have implications for understanding connectome maturation principles in normal development and developmental disorders.
基金This work was supported by the Natural Science Foundation of Shandong Province(grant no.ZR2021MH384)the Study Abroad Program of Shandong Province(grant no.201803053).
文摘A dysbiosis in microbial diversity or functionality can promote disease development.Emerging preclinical and clinical evidence emphasizes the interplay between microbiota and both disease evolution and the treatment response of different cancers.One bacterium that has garnered much attention in a few cancer microbiota studies is Fusobacterium nucleaum(Fn).To provide updated knowledge of the functional role of Fn in cancer prevention and management,this review summarizes the relationship among Fn,cancer,and chemoimmunotherapy response,with the potential mechanisms of action also intensively discussed,which will benefit the development of strategies to prevent or treat cancer via Fn-based therapeutic interventions.
基金This work was supported by the National Natural Science Foundation of China(No.52073201).
文摘Main observation and conclusion Ring-opening metathesis polymerization(ROMP)is a powerful toolbox in preparation of bottlebrush polymers for its high activity.However,the ROMP of macromonomers with repeating tertiary amine groups,for example,poly(2-(dimethylamino)ethyl methacrylate)(PDMAEMA).
