A novel cerebrovascular drug-coated balloon catheter for treating symptomatic intracranial atherosclerotic stenosis lesions:Study protocol for a prospective,multicenter,single-arm,target-value clinical trial

Background:Previous single-center studies have demonstrated that drug-coated balloons(DCBs)may reduce restenosis rates,which is an important factor affecting the prognosis for intracranial interventional therapy.However,currently available cardiac DCBs are not always suitable for the treatment of intracranial atherosclerotic stenosis(ICAS).This study aimed to evaluate the safety and efficacy of a novel DCB catheter designed for patients with severely symptomatic ICAS.Methods:This prospective,multicenter,single-arm,target-value clinical trial was conducted in 9 Chinese stroke centers to evaluate the safety and efficacy of a novel DCB catheter for treating symptomatic severe ICAS.Primary metrics and other indicators were collected and analyzed using SAS version 9.4(SAS Institute,Cary,NC,USA).Results:A total of 155 patients were enrolled in this study.The preliminary collection of follow-up data has been completed,while data quality control is ongoing.Conclusion:Results of this study demonstrated the patency rate,safety,and effectiveness of a novel on-label paclitaxel DCB designed for the treatment of ICAS.Ethics and dissemination:This study,involving human participants,was reviewed and approved by the Ethics Committee of Drugs(Devices)Clinical Experiment at Henan Provincial People’s Hospital(reference number:2020-145-03)and other research centers participating in the clinical trial.The results of this study will be presented at international conferences and sent to peer-reviewed journals for publication.Standard protocol items:The Recommendations for Interventional Trials checklist was used when drafting the study protocol.Trial registration number:Registered with the Chinese Clinical Trial Registry on June 11,2021(Chi CTR2100047223).

Ultra-light and flexible pencil-trace anode for high performance potassium-ion and lithium-ion batteries

Engineering design of battery configurations and new battery system development are alternative approaches to achieve high performance batteries. A novel flexible and ultra-light graphite anode is fabricated by simple friction drawing on filter paper with a commercial 8 B pencil.Compared with the traditional anode using copper foil as current collector, this innovative current-collector-free design presents capacity improvement of over 200% by reducing the inert weight of the electrode. The as-prepared pencil-trace electrode exhibits excellent rate performance in potassium-ion batteries(KIBs), significantly better than in lithium-ion batteries(LIBs), with capacity retention of 66% for the KIB vs. 28% for the LIB from 0.1 to 0.5 A g^(-1). It also shows a high reversible capacity of ～230 mAh g^(-1) at 0.2 A g^(-1), 75% capacity retention over350 cycles at 0.4 A g^(-1)and the highest rate performance(based on the total electrode weight) among graphite electrodes for K+ storage reported so far.

Evaluation of using a double helical, closed-cell stent-retriever(Skyflow) for thrombectomy procedures in acute arterial occlusion: A preclinical study and a clinical trial

Background and purpose:Stent retriever thrombectomy is the standard therapeutic approach for ischemic stroke with acute large-vessel occlusion.This study evaluated the safety and efficacy of a new thrombectomy device(Skyflow)in the treatment of acute ischemic stroke.Methods:After an arterial occlusion model was established,stent-retriever thrombectomy was performed.Digital subtraction angiography(DSA)and autopsy were carried out immediately after thrombectomy in six animals in the acute experimental group.Simulated stent-retriever thrombectomy was performed for three animals in the subacute experimental group,and follow-up angiography and vascular pathological examination were assessed 90 days after the operation.In the clinical trial,192 patients with intracranial anterior circulation large vessel occlusion,within 8 h of symptom onset,were included to undergo thrombectomy with either Skyflow or Solitaire FR stent retriever.Efficacy and safety endpoints were recorded(including successful reperfusion,favorable clinical outcomes,time from puncture to reperfusion,instrument operation success rates and National Institutes of Health Stroke Scale(NIHSS)scores at 7 days for efficacy endpoints,and symptomatic intracranial hemorrhage(sICH),subarachnoid hemorrhage(SAH)and all-cause mortality rates for safety endpoints).Results:All blood vessels achieved successful recanalization in the animal models.In the clinical trial,successful recanalization was attained in 88.4%of patients of the Skyflow group,which was comparable to that of the Solitaire FR group(82.5%)in the full analysis set of the clinical trial.There were no severe complications on DSA,an animal autopsy,or vessel pathological examination in animal experiments.Additionally,no statistically significant difference was observed between the Skyflow and Solitaire FR groups in the clinical trial regarding the safety endpoints.Conclusion:This study showed that the new Skyflow stent retriever is safe and effective for the treatment of acute large vessel occlusion,as demonstrated in our animal study and human trial.

Research on energy structure and development strategy from 2010 to 2015 in Qingdao, China

With the fast development of Qingdao's economy, the energy consumption is increasing significantly. In this paper, based on the energy statistic data in Qingdao area from 2010 to 2015,energy consumption structure was analyzed, indicating the existence of single energy structure;that is, coal, petroleum, and natural gas are dominant in the area. Thus, some issues between energy supply and demand have been brought. To solve present problem, we put forward to formulate the development strategy of energy, including energy savings, the exploitation of petroleum and natural gas resources, the development and utilization of renewable energy sources, and energy policy. It is worthy of mentioning that, according to the geological investigation, the shale gas may be abundant in Qingdao area and the gas resource amount estimated is huge. This is our first finding, important for developing unconventional energy and adjusting the energy structure in Qingdao in the future. Therefore, we suggest that Qingdao government should take action to develop local new energy resources for satisfying the energy demand.

Boosting lifespan of conversion-reaction anodes for full/half potassium-ion batteries via multi-dimensional carbon nano-architectures confinement effect

Transition metal selenides are regarded as prospective conversion-reaction anodes for potassium-ion batteries(PIBs)because of their relatively high electrical conductivity,large theoretical specific capacity,abundant resources and low cost.The challenge of the metal selenides originates from a serious volume change during cycling,which induces serious structural collapse and fast capacity degradation.In the present work,the multi-dimensional carbon nano-architectures confined bimetallic selenides(ZnSe/CoSe_(2)@N-CNTs/rGO)were constructed by a facile MOF-assisted strategy.In such special nanoarchitectures,N-doped CNTs protect the metal selenides centers from serious volume expansion/electrode pulverization,as well as improve the sluggish kinetics.ZnSe/CoSe_(2)@N-CNTs/rGO electrode boosts the lifespan of half PIBs with a large discharge specific capacity of 200 m Ah g^(-1)at 2 A g^(-1)after 3800 cycles.The full PIBs battery with ZnSe/CoSe_(2)@N-CNTs/rGO electrode as anode and Prussian blue as cathode exhibits well electrochemical performance(151 m Ah g^(-1)at 100 m A g^(-1)after 100 cycles).DFT calculation suggests that the CNTs could change the K+adsorption energy and decrease K+diffusion energy barrier,which dramatically enhances K+storage kinetics.This work offers an effective material engineering approach for designing hierarchical“all-in-one”electrodes with high excellent cycling stability for PIBs.

Safety and efficacy of the SeparGateTM balloon-guiding catheter in neurointerventional surgery:A prospective,multicenter,single-arm clinical trial

Objective:To evaluate the safety and efficacy of the SeparGateballoon-guiding catheter(BGC)for blocking flow and delivering devices in neurointerventional surgery.Method:This prospective multicenter single-arm trial enrolled patients who received BGC adjuvant therapy to provide temporary blood flow arrest of the supra-aortic arch arteries and their branch vessels in interventional therapy.The primary endpoint was immediate procedural success rate in flow arrest,device delivery,and withdrawal.The efficacy endpoints were intraoperative product performance,including rigidity,smoothness,fracture resistance of the catheter wall,catheter push performance,compatibility and radiopaque display,integrity,adhesion thrombus after withdrawal and balloon rupture.The safety endpoints were adverse and serious adverse events associated with the test device and serious adverse events resulting in death or serious health deterioration.Result:A total of 129 patients were included;of them,128 were analyzed in the full analysis set(FAS)and per protocol set(PPS).Immediate procedural success was achieved in 97.7%of patients with FAS and PPS.The lower bound of the 95%confidence interval was 94.6%,higher than the preset efficacy margin of 94%.Device-related adverse events occurred in 2(1.6%)cases.One was mild adverse event of vasospasm,which resolved spontaneously.The other was serious adverse event of dissection aggravation,which was treated with stenting angioplasty.No device defects were observed.Conclusion:In neurointerventional surgery,the SeparGateBGC can be used to temporarily block the flow of the supra-aortic arch arteries and their branch vessels and guide the interventional device to the target vascular position.

Recent Progress of Catalytic Cathodes for Lithium-oxygen Batteries

Lithium-oxygen batteries are among the most promising electrochemical energy storage systems,which have attracted significant attention in the past few years duo to its far more energy density than lithium-ion batteries.Lithium oxygen battery energy storage is a reactive storage mechanism,and the discharge and charge processes are usually called oxygen reduction reaction(ORR)and oxygen evolution reaction(OER).Consequently,complex systems usually create complex problems,lithium oxygen batteries also face many problems,such as excessive accumulation of discharge products(Li_(2)O_(2))in the cathode pores,resulting in reduced capacity,unstable cycling performance and so on.Cathode catalyst,which could influence the kinetics of OER and ORR in lithium oxygen(Li-O_(2))battery,is one of the decisive factors to determine the electrochemical performance of the battery,so the design of cathode catalyst is vitally important.This review discusses the catalytic cathode materials,which are divided into four parts,carbon based materials,metals and metal oxides,composite materials and other materials.

Hierarchical and lamellar porous carbon as interconnected sulfur host and polysulfide-proof interlayer for Li–S batteries

A robust three-dimensional(3D)interconnected sulfur host and a polysulfide-proof interlayer are key components in high-performance Li–S batteries.Herein,cellulose-based 3D hierarchical porous carbon(HPC)and two-dimensional(2D)lamellar porous carbon(LPC)are employed as the sulfur host and polysulfide-proof inter-layer,respectively,for a Li–S battery.The 3D HPC displays a cross-linked macroporous structure,which allows high sulfur loading and restriction capability and provides unobstructed electrolyte diffusion channels.With a stackable carbon sheet of 2D LPC that has a large plane view size and is ultrathin and porous,the LPC-coated separator effectively inhibits polysulfides.An optimized combination of the HPC and LPC yields an electrode structure that effectively protects the lithium anode against corrosion by polysulfides,giving the cell a high ca-pacity of 1339.4 mAh g^(-1) and high stability,with a capacity decay rate of 0.021% per cycle at 0.2C.This work provides a new understanding of biomaterials and offers a novel strategy to improve the performance of Li–S batteries for practical applications.

Metal chalcogenides for potassium storage

Potassium-based energy storage technologies,especially potassium ion batteries(PIBs),have received great interest over the past decade.A pivotal challenge facing high-performance PIBs is to identify advanced electrode materials that can store the large-radius K+ions,as well as to tailor the various thermodynamic parameters.Metal chalcogenides are one of the most promising anode materials,having a high theoretical specific capacity,high in-plane electrical conductivity,and relatively small volume change on charge/discharge.However,the development of metal chalcogenides for PIBs is still in its infancy because of the limited choice of high-performance electrode materials.However,numerous efforts have been made to conquer this challenge.In this article,we overview potassium storage mechanisms,the technical hurdles,and the optimization strategies for metal chalcogenides and highlight how the adjustment of the crystalline structure and choice of the electrolyte affect the electrochemical performance of metal-chalcogenide-based electrode materials.Other potential potassium-based energy storage systems to which metal chalcogenides can be applied are also discussed.Finally,future research directions focusing on metal chalcogenides for potassium storage are proposed.

Late Mesozoic rifting and its deep dynamic mechanisms in the central Sulu orogenic belt: Records from Lingshan Island

The Lingshan Island scientific drill confirms that two episodes(Laiyang period and Qingshan period) of rifting developed in the central Sulu orogenic belt(SOB) in Late Mesozoic. With a set of methods including fieldwork, drilling, core logging, zircon U-Pb dating and whole rock geochemistry applied, the age, the depositional sequence and the deep dynamic mechanisms of rift evolution were unraveled. The stratigraphic sequence of the Laiyang-Qingshan Groups on Lingshan Island was composed of two different rifting sequences:(1) Laiyang Group(147–125 Ma), which consists of deep-water gravity flow deposits with interlayers of intermediate volcanic rocks;and(2) Lower Qingshan Group(125–119 Ma), which unconformably overlies the former sequence and contains subaerial volcanic deposits and terrestrial deposits. The tectonic environment changed during the evolution of these two episodes of rifting: the rift was in a NNW-SSE extensional environment in the Laiyang period and showed the typical passive rifting character that “lithospheric extension and rifting preceded volcanism”. The passive rifting period was ended by a short WNW-ESE compression at about 125 Ma. After that, the tectonic environment transferred to a strong NW-SE extensional environment and the rifting evolved into a volcanic arc basin in the Qingshan period. The igneous rocks are shoshonitic to high-K calc-alkaline trachyandesites to trachytes with a few intercalated lamprophyres and a rhyolite.The geochemical characteristics of the igneous rocks indicate that they are mantle-derived melts with a metasomatized mantle source and/or crustal contamination. In addition, an increased thinning of the lithosphere happened during the rifting episodes.The low-angle subduction of the Paleo-Pacific plate in the Jurassic weakened the thickened SOB lithospheric mantle. The rollback of the subducting plate started in late Jurassic to early Cretaceous, and the SOB lithospheric mantle was delaminated synchronously because of the gravity collapse. Thus, this caused passive rifting in the Laiyang period. Thereafter, the rollback and trench retreat of the high-angle subducting Paleo-Pacific plate would have achieved its climax, resulting in the strong regional extension. Passive rifting was ended by the crustal uplift caused by asthenospheric upwelling beneath the rift. The lower crust was heated by the upwelling asthenosphere and partially melted to form felsic melts, which were emplaced upwards and erupted explosively. The rift evolved into a volcanic arc basin in the Qingshan period and showed some characteristics of active rifting. Above all, a passive rifting in the Laiyang period and a volcanic arc basin in the Qingshan period developed successively in the Lingshan Island area(the central SOB). This records the transfer of the study area from the Paleo-Tethys tectonic domain to the circum-Pacific tectonic domain. The delamination of SOB lithospheric mantle and the upwelling of asthenospheric material were the deep dynamic mechanisms driving the development and evolution of two rift episodes. Additionally, the rift development was controlled remotely by the subduction of the Paleo-Pacific plate.

m6A RNA methylation-mediated HNF3γreduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance

Hepatocyte nuclear factor 3γ(HNF3γ)is a hepatocyte nuclear factor,but its role and clinical significance in hepatocellular carcinoma(HCC)remain unclear.Herein,we report that HNF3γexpression is downregulated in patient HCC and inversely correlated with HCC malignancy and patient survival.Moreover,our data suggested that the HNF3γreduction in HCC could be mediated by METTL14-dependent m6A methylation of HNF3γmRNA.HNF3γexpression was increased during hepatic differentiation and decreased in dedifferentiated HCC cells.Interestingly,HNF3γdelivery promoted differentiation of not only HCC cells but also liver CSCs,which led to suppression of HCC growth.Mechanistic analysis suggested an HNF3γ-centered regulatory network that includes essential liver differentiation-associated transcription factors and functional molecules,which could synergistically facilitate HCC cell differentiation.More importantly,enforced HNF3γexpression sensitized HCC cells to sorafenib-induced growth inhibition and cell apoptosis through transactivation of OATP1B1 and OATP1B3 expression,which are major membrane transporters for sorafenib uptake.Clinical investigation showed that patient-derived HCC xenografts with high HNF3γexpression exhibited a sorafenib response and patients with high HCC HNF3γlevels benefited from sorafenib therapy.Together,these results suggest that HNF3γplays an essential role in HCC differentiation and may serve as a therapeutic target and predictor of sorafenib benefit in patients.

Late Jurassic to early Cretaceous magnetostratigraphy of scientific drilling core LK-1 in the Lingshan Island of Riqingwei Basin,eastern China

The Sulu orogenic belt is an uplift zone that was formed in the Late Triassic.Several Jurassic to Cretaceous sedimentary successions have been recognized within the Sulu orogenic belt in recent studies,including outcrops that are considered to be related to the newly discovered Riqingwei Basin.This basin has been the focus of extensive study due to its continuous Cretaceous rock sequence,geological location and petroleum resource potential.However,the lack of a consolidated chronology for the strata has precluded a better understanding of stratigraphy,tectonic evolution and resource potential of the Riqingwei Basin.Here,we present the results of a new magnetostratigraphic study of the continental scientific drilling borehole LK-1,which is located on Lingshan Island,offshore Shandong province,eastern China.The goals of this study are to(1)refine the Late Jurassic to Early Cretaceous chronostratigraphic framework of the Riqingwei Basin,and(2)investigate the location of the J/K boundary in the Borehole Core LK-1.The observed patterns of the paleomagnetic polarity zone in the LK-1 borehole correlate well with the geomagnetic polarity time scale(GPTS),and the continuous magnetostratigraphy profile defined in this core indicates an age ranging from 146.5 to 125.8 Ma for the samples interval.The sediment accumulation rates(SAR)of LK-1 show one period of high SAR(~10.5 cm kyr^(-1))at 135.3–130.6 Ma and two periods of low SAR(~4.8 and~2.2 cm kyr^(-1))at145.7–135.3 and 130.6–125.8 Ma,respectively.In addition,the magnetostratigraphic results suggest that the Jurassic-Cretaceous(J/K)boundary of the LK-1 is located within the magnetozone N21.2 n(~1254 m).This comprehensive geochronologic framework provides a good correlation of the marine Upper Jurassic to Lower Cretaceous strata in the Riqingwei Basin to other marine strata and continental sequences,in addition to providing a foundation for the study of the structural evolution of eastern China.

An Imported Case and an Infected Close Contact of the Omicron Variant of SARS-CoV-2—Guangdong Province,China,December 13,2021

On November 27,2021,a 67-year-old male returning from Canada via airplane was transferred to the central isolation hotel in Shanghai.During the quarantine,his 1st,4th,7th,and 14th days of specimens returned negative for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which causes coronavirus disease 2019(COVID-19).On December 11,he completed 14 days of centralized isolation and returned to Guangzhou from Shanghai via airplane,then he was closed-loop transferred to Yuexiu District for a 7-day home isolation.On December 12,the local Community Health Service Center routinely collected his throat swab and the result returned to COVID-19 positive on December 13,2021.He was transported to the Guangzhou Eighth People’s Hospital for isolated treatment by negative pressure ambulance on the same day.The patient had two inflamed lungs according to the chest computed tomography(CT)examination,but his most recently updated condition was stable.An estimated 600 close contacts were identified and were placed in centralized isolation.On December 16,one of the close contacts,a 70-year-old female also tested positive for COVID-19.She lived on the lower floor of the same type of apartment as the imported case and spent 19 hours in the same building.

Urban Geospatial Information Acquisition Mobile Mapping System based on close-range photogrammetry and IGS site calibration

The measurement accuracy of the Mobile Mapping System (MMS) is the main problem, which restricts its development and application, so how to calibrate the MMS to improve its measure-ment accuracy has always been a research hotspot in the industry. This paper proposes a position and attitude calibration method with error correction based on the combination of the feature point and feature surface. First, the initial value of the spatial position relation-ship between each sensor of MMS is obtained by close-range photogrammetry. Second, the optimal solution for error correction is calculated by feature points in global coordinates jointly measured with International GNSS Service (IGS) stations. Then, the final transformation para-meters are solved by combining the initial values obtained originally, thereby realizing the rapid calibration of the MMS. Finally, it analyzed the RMSE of MMS point cloud after calibration, and the results demonstrate the feasibility of the calibration approach proposed by this method. Under the condition of a single measurement sensor accuracy is low, the plane and elevation absolute accuracy of the point cloud after calibration can reach 0.043 m and 0.072 m, respectively, and the relative accuracy is smaller than 0.02 m. It meets the precision require-ments of data acquisition for MMS. It is of great significance for promoting the development of MMS technology and the application of some novel techniques in the future, such as auton-omous driving, digital twin city, urban brain et al.

m6A RNA methylation-mediated HNF3γ reduction rendershepatocellular carcinoma dedifferentiation and sorafenibresistance

Hepatocyte nuclear factor 3γ(HNF3γ)is a hepatocyte nuclear factor,but its role and clinical significance in hepatocellular carcinoma(HCC)remain unclear.Herein,we report that HNF3γexpression is downregulated in patient HCC and inversely correlated with HCC malignancy and patient survival.Moreover,our data suggested that the HNF3γreduction in HCC could be mediated by METTL14-dependent m6A methylation of HNF3γmRNA.HNF3γexpression was increased during hepatic differentiation and decreased in dedifferentiated HCC cells.Interestingly,HNF3γdelivery promoted differentiation of not only HCC cells but also liver CSCs,which led to suppression of HCC growth.Mechanistic analysis suggested an HNF3γ-centered regulatory network that includes essential liver differentiation-associated transcription factors and functional molecules,which could synergistically facilitate HCC cell differentiation.More importantly,enforced HNF3γexpression sensitized HCC cells to sorafenib-induced growth inhibition and cell apoptosis through transactivation of OATP1B1 and OATP1B3 expression,which are major membrane transporters for sorafenib uptake.Clinical investigation showed that patient-derived HCC xenografts with high HNF3γexpression exhibited a sorafenib response and patients with high HCC HNF3γlevels benefited from sorafenib therapy.Together,these results suggest that HNF3γplays an essential role in HCC differentiation and may serve as a therapeutic target and predictor of sorafenib benefit in patients.