A crosslinked chitosan film with α-tocopherol was produced by a solution casting method. The appearance, mechanical properties, morphology, barrier properties and release kinetics of the α-tocopherol were evaluated....A crosslinked chitosan film with α-tocopherol was produced by a solution casting method. The appearance, mechanical properties, morphology, barrier properties and release kinetics of the α-tocopherol were evaluated. The addition of glutaraldehyde and α-tocopherol decreased the lightness and greenness and increased the yellowness of the chitosan-based film. Moreover, it also affected the compatibility of the film due to a decrease in the opacity values. The elongation at break(EB) and tensile strength(TS) values of the film decreased when the glutaraldehyde and α-tocopherol were added. In contrast, the Young’s modulus(YM) values increased. SEM micrographs showed coarse spots and pores on the surface and cross-section of the film when compared with the chitosan film. Based on the results, it was indicated that the chitosan structure was disconnected by the α-tocopherol, and the glutaraldehyde as a crosslinking agent generated a link between the chitosan network, which could be the cause of the reduced flexibility and the increased surface roughness of the film. However, the glutaraldehyde and α-tocopherol did not result in a significant difference in water vapour permeability(WVP) values. The glutaraldehyde influenced the release kinetics of the α-tocopherol as seen by the decrease of the diffusion coefficient values that were calculated using the Fickian diffusion model.展开更多
基金Supported by Tianjin Science and Technology Planning Project(No.18PTSYJC00140)
文摘A crosslinked chitosan film with α-tocopherol was produced by a solution casting method. The appearance, mechanical properties, morphology, barrier properties and release kinetics of the α-tocopherol were evaluated. The addition of glutaraldehyde and α-tocopherol decreased the lightness and greenness and increased the yellowness of the chitosan-based film. Moreover, it also affected the compatibility of the film due to a decrease in the opacity values. The elongation at break(EB) and tensile strength(TS) values of the film decreased when the glutaraldehyde and α-tocopherol were added. In contrast, the Young’s modulus(YM) values increased. SEM micrographs showed coarse spots and pores on the surface and cross-section of the film when compared with the chitosan film. Based on the results, it was indicated that the chitosan structure was disconnected by the α-tocopherol, and the glutaraldehyde as a crosslinking agent generated a link between the chitosan network, which could be the cause of the reduced flexibility and the increased surface roughness of the film. However, the glutaraldehyde and α-tocopherol did not result in a significant difference in water vapour permeability(WVP) values. The glutaraldehyde influenced the release kinetics of the α-tocopherol as seen by the decrease of the diffusion coefficient values that were calculated using the Fickian diffusion model.
