Continuous flow has recently emerged as a powerful enabling technology that greatly improves many reactions' efficiency. Here, we apply the technology to intermolecular [4+2] annulation of cyclobutylanilines with ...Continuous flow has recently emerged as a powerful enabling technology that greatly improves many reactions' efficiency. Here, we apply the technology to intermolecular [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes by photoredox catalysis. An across-the-board improvement in the annulation's efficiency is noticed. Moreover, a gram-scale annulation is successfully demonstrated in continuous flow using a much lower catalyst loading.展开更多
基金supported by the University of Arkansasthe Arkansas Bioscience Institute+1 种基金the National Institutes of Health(P30 GM103450)from the National Institute of General Medical Sciencesthe NSF Career Award(CHE-1255539)
文摘Continuous flow has recently emerged as a powerful enabling technology that greatly improves many reactions' efficiency. Here, we apply the technology to intermolecular [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes by photoredox catalysis. An across-the-board improvement in the annulation's efficiency is noticed. Moreover, a gram-scale annulation is successfully demonstrated in continuous flow using a much lower catalyst loading.
