We present a cut-cell method for the simulation of 2D incompressible flows past obstacles.It consists in using the MAC scheme on cartesian grids and imposing Dirchlet boundary conditions for the velocity field on the ...We present a cut-cell method for the simulation of 2D incompressible flows past obstacles.It consists in using the MAC scheme on cartesian grids and imposing Dirchlet boundary conditions for the velocity field on the boundary of solid structures following the Shortley-Weller formulation.In order to ensure local conservation properties,viscous and convecting terms are discretized in a finite volume way.The scheme is second order implicit in time for the linear part,the linear systems are solved by the use of the capacitance matrix method for non-moving obstacles.Numerical results of flows around an impulsively started circular cylinder are presented which confirm the efficiency of the method,for Reynolds numbers 1000 and 3000.An example of flows around a moving rigid body at Reynolds number 800 is also shown,a solver using the PETSc-Library has been prefered in this context to solve the linear systems.展开更多
Invasive micropapillary carcinomas (IMPC) of the breast account for less than 2% of all breast cancers and have been recently described as luminal B carcinomas. CD24, CD44, ALDH1 and EZH2 are commonly used as stem-cel...Invasive micropapillary carcinomas (IMPC) of the breast account for less than 2% of all breast cancers and have been recently described as luminal B carcinomas. CD24, CD44, ALDH1 and EZH2 are commonly used as stem-cell markers that display differential expression as a function of stage and molecular type, but their pattern of expression according to this rare histological type remains poorly defined and unknown for EZH2. We assessed expression of these markers in a series of 28 micropapillary breast carcinomas and compared the results with those obtained in a series of luminal A (27 cases) and B (34 cases) invasive carcinomas not otherwise specified (IC-NST). CD24 and CD44 were expressed in most cases. However, CD24 was expressed at the inverted apical membrane in 85% of invasive micropapillary carcinoma and at the apical pole of gland-forming cells in 45% of luminal A (p-val = 6.8 × 10-4) and 13% of luminal B cases (p-val = 1.1 × 10-7). ALDH1 was expressed in the stroma in most tumors, but in only 25%, 11% and 15% in epithelial cells of IMPC, luminal A and B IC-NST, respectively. Nuclear expression of EZH2 was not observed in luminal A tumors, and was detected in 35% (12/34) of luminal B carcinomas (p-val = 6.1 × 10-3) and only 4% (1/28) of invasive micropapillary carcinomas. This series shows that invasive micropapillary carcinomas harbor a CD24-positive inverted apical pole associated with weak EZH2 expression, phenotypical characteristics that distinguish this entity from other luminal carcinomas.展开更多
法国军方首席参谋长皮埃尔·维利埃（Pierre de Villiers）在2017年7月19日出人意料地辞职了．终结了他与法国总统马克龙因大规模削减国防预算而意见不合的局面。此前．法国财政部长曾宣布．作为政府总体支出降低计划的一部分．201...法国军方首席参谋长皮埃尔·维利埃（Pierre de Villiers）在2017年7月19日出人意料地辞职了．终结了他与法国总统马克龙因大规模削减国防预算而意见不合的局面。此前．法国财政部长曾宣布．作为政府总体支出降低计划的一部分．2017年的国防开支将减少85亿欧元（10亿美元）。展开更多
文摘We present a cut-cell method for the simulation of 2D incompressible flows past obstacles.It consists in using the MAC scheme on cartesian grids and imposing Dirchlet boundary conditions for the velocity field on the boundary of solid structures following the Shortley-Weller formulation.In order to ensure local conservation properties,viscous and convecting terms are discretized in a finite volume way.The scheme is second order implicit in time for the linear part,the linear systems are solved by the use of the capacitance matrix method for non-moving obstacles.Numerical results of flows around an impulsively started circular cylinder are presented which confirm the efficiency of the method,for Reynolds numbers 1000 and 3000.An example of flows around a moving rigid body at Reynolds number 800 is also shown,a solver using the PETSc-Library has been prefered in this context to solve the linear systems.
文摘Invasive micropapillary carcinomas (IMPC) of the breast account for less than 2% of all breast cancers and have been recently described as luminal B carcinomas. CD24, CD44, ALDH1 and EZH2 are commonly used as stem-cell markers that display differential expression as a function of stage and molecular type, but their pattern of expression according to this rare histological type remains poorly defined and unknown for EZH2. We assessed expression of these markers in a series of 28 micropapillary breast carcinomas and compared the results with those obtained in a series of luminal A (27 cases) and B (34 cases) invasive carcinomas not otherwise specified (IC-NST). CD24 and CD44 were expressed in most cases. However, CD24 was expressed at the inverted apical membrane in 85% of invasive micropapillary carcinoma and at the apical pole of gland-forming cells in 45% of luminal A (p-val = 6.8 × 10-4) and 13% of luminal B cases (p-val = 1.1 × 10-7). ALDH1 was expressed in the stroma in most tumors, but in only 25%, 11% and 15% in epithelial cells of IMPC, luminal A and B IC-NST, respectively. Nuclear expression of EZH2 was not observed in luminal A tumors, and was detected in 35% (12/34) of luminal B carcinomas (p-val = 6.1 × 10-3) and only 4% (1/28) of invasive micropapillary carcinomas. This series shows that invasive micropapillary carcinomas harbor a CD24-positive inverted apical pole associated with weak EZH2 expression, phenotypical characteristics that distinguish this entity from other luminal carcinomas.
