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Epitranscriptomics of cancer 被引量:2
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作者 Marina Tusup thomas kundig Steve Pascolo 《World Journal of Clinical Oncology》 CAS 2018年第3期42-55,共14页
The functional impact of modifications of cellular RNAs,including m RNAs,mi RNAs and lnc RNAs,is a field of intense study.The role of such modifications in cancer has started to be elucidated.Diverse and sometimes opp... The functional impact of modifications of cellular RNAs,including m RNAs,mi RNAs and lnc RNAs,is a field of intense study.The role of such modifications in cancer has started to be elucidated.Diverse and sometimes opposite effects of RNA modifications have been reported.Some RNA modifications promote,while ot-hers decrease the growth and invasiveness of cancer.The present manuscript reviews the current knowledge on the potential impacts of N6-Methyladenosine,Pse-udouridine,Inosine,2’O-methylation or methylcytidine in cancer’s RNA.It also highlights the remaining qu-estions and provides hints on research avenues and potential therapeutic applications,whereby modulating dynamic RNA modifications may be a new method to treat cancer. 展开更多
关键词 RNA modifications N6-methyladenosine 5-methylcytidine 2’O-methylation or methylcytidine PSEUDOURIDINE INOSINE
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