Background:The aim is to study the relationship between single nucleotide polymorphism(SNP)of polycystic ovary syndrome(PCOS)susceptibility locus in the THADA gene(rsl3429458)and PCOS in Xinjiang Uygur women.Methods:S...Background:The aim is to study the relationship between single nucleotide polymorphism(SNP)of polycystic ovary syndrome(PCOS)susceptibility locus in the THADA gene(rsl3429458)and PCOS in Xinjiang Uygur women.Methods:Seventy-seven Uygur patients with PCOS were enrolled from Reproductive Center of the First Affiliated Hospital of Xinjiang Medical University during May 2013 to January 2017;whereas 62 matched Uighur women of reproductive age with normal menstruation were set as the control group.Results:(1)The levels of body mass index,luteinizing hormone,testosterone(T),blood glucose after 2 h of oral glucose tolerance test,insulin,triglyceride(TG)and low-density lipoprotein in PCOS group were much higher than control group(P>0.05).(2)The frequencies of TT,TG,and GG of SNP13429458 in PCOS were 63.5%,26.2%,and 10.3%,respectively;compared to the frequencies in the control group being 48.5%,39.3%,and 22.2%,respectively.The difference between these two groups was statistically significant(P>0.05).The allele frequency of T was much higher in PCOS than control women(76.5%vs.61.4%,P>0.05).Conclusions:SNPl3429458 in the THADA gene is associated with the susceptibility of PCOS in Uygur women,which may be involved in the metabolic abnormality.展开更多
Background:To investigate the effect of body mass index(BMI)on the outcomes of in vitro fertilization–embryo transfer(IVF-ET)treatment,and to provide evidence for future clinical studies of infertile women with diffe...Background:To investigate the effect of body mass index(BMI)on the outcomes of in vitro fertilization–embryo transfer(IVF-ET)treatment,and to provide evidence for future clinical studies of infertile women with different body mass indices.Methods:The relationship between pregnancy outcome and BMI in 717 infertile women who underwent IVF-ET was analyzed.Results:A total of 531 out of 717 patients were classified as having a standard body weight,and 20 patients were classified as obese.We found a significant difference in the basal follicle-stimulating hormone(FSH)level among the groups;the basal FSH level was lower in the obese group(6.80±2.20 IU/L)than in the standard weight group(7.56±2.25 IU/L).However,there were no significant differences in the age of females,the age of males,basal estradiol(E2)and luteinizing hormone(LH)levels,length of infertility,and history of dysmenorrhea.Although the pregnancy rate was highest(54.6%)in the standard weight group and lowest(45.0%)in the obese group,there was no significant difference among these groups by Chi-square test analysis.Furthermore,there were no significant differences in gonadotropin-releasing hormone agonist days,number of 2PN,and the LH level on the day of human chorionic gonadotropin treatment among the groups.Conclusions:Obese women can improve a successful pregnancy rate after undergoing IVF–ET treatment by controlling weight.展开更多
基金This project was supported by the Natural Science Foundation of Xinjiang Uygur Autonomous Region(NO.2013211A087)。
文摘Background:The aim is to study the relationship between single nucleotide polymorphism(SNP)of polycystic ovary syndrome(PCOS)susceptibility locus in the THADA gene(rsl3429458)and PCOS in Xinjiang Uygur women.Methods:Seventy-seven Uygur patients with PCOS were enrolled from Reproductive Center of the First Affiliated Hospital of Xinjiang Medical University during May 2013 to January 2017;whereas 62 matched Uighur women of reproductive age with normal menstruation were set as the control group.Results:(1)The levels of body mass index,luteinizing hormone,testosterone(T),blood glucose after 2 h of oral glucose tolerance test,insulin,triglyceride(TG)and low-density lipoprotein in PCOS group were much higher than control group(P>0.05).(2)The frequencies of TT,TG,and GG of SNP13429458 in PCOS were 63.5%,26.2%,and 10.3%,respectively;compared to the frequencies in the control group being 48.5%,39.3%,and 22.2%,respectively.The difference between these two groups was statistically significant(P>0.05).The allele frequency of T was much higher in PCOS than control women(76.5%vs.61.4%,P>0.05).Conclusions:SNPl3429458 in the THADA gene is associated with the susceptibility of PCOS in Uygur women,which may be involved in the metabolic abnormality.
基金The Natural Science Foundation of Xinjiang Uyghur Autonomous Region(No.2013211A087).
文摘Background:To investigate the effect of body mass index(BMI)on the outcomes of in vitro fertilization–embryo transfer(IVF-ET)treatment,and to provide evidence for future clinical studies of infertile women with different body mass indices.Methods:The relationship between pregnancy outcome and BMI in 717 infertile women who underwent IVF-ET was analyzed.Results:A total of 531 out of 717 patients were classified as having a standard body weight,and 20 patients were classified as obese.We found a significant difference in the basal follicle-stimulating hormone(FSH)level among the groups;the basal FSH level was lower in the obese group(6.80±2.20 IU/L)than in the standard weight group(7.56±2.25 IU/L).However,there were no significant differences in the age of females,the age of males,basal estradiol(E2)and luteinizing hormone(LH)levels,length of infertility,and history of dysmenorrhea.Although the pregnancy rate was highest(54.6%)in the standard weight group and lowest(45.0%)in the obese group,there was no significant difference among these groups by Chi-square test analysis.Furthermore,there were no significant differences in gonadotropin-releasing hormone agonist days,number of 2PN,and the LH level on the day of human chorionic gonadotropin treatment among the groups.Conclusions:Obese women can improve a successful pregnancy rate after undergoing IVF–ET treatment by controlling weight.
