A growing number of studies have demonstrated that repeated exposure to sevoflurane during development results in persistent social abnormalities and cognitive impairment.Davunetide,an active fragment of the activity-...A growing number of studies have demonstrated that repeated exposure to sevoflurane during development results in persistent social abnormalities and cognitive impairment.Davunetide,an active fragment of the activity-dependent neuroprotective protein(ADNP),has been implicated in social and cognitive protection.However,the potential of davunetide to attenuate social deficits following sevoflurane exposure and the underlying developmental mechanisms remain poorly understood.In this study,ribosome and proteome profiles were analyzed to investigate the molecular basis of sevoflurane-induced social deficits in neonatal mice.The neuropathological basis was also explored using Golgi staining,morphological analysis,western blotting,electrophysiological analysis,and behavioral analysis.Results indicated that ADNP was significantly down-regulated following developmental exposure to sevoflurane.In adulthood,anterior cingulate cortex(ACC)neurons exposed to sevoflurane exhibited a decrease in dendrite number,total dendrite length,and spine density.Furthermore,the expression levels of Homer,PSD95,synaptophysin,and vglut2 were significantly reduced in the sevoflurane group.Patch-clamp recordings indicated reductions in both the frequency and amplitude of miniature excitatory postsynaptic currents(mEPSCs).Notably,davunetide significantly ameliorated the synaptic defects,social behavior deficits,and cognitive impairments induced by sevoflurane.Mechanistic analysis revealed that loss of ADNP led to dysregulation of Ca^(2+)activity via the Wnt/β-catenin signaling,resulting in decreased expression of synaptic proteins.Suppression of Wnt signaling was restored in the davunetide-treated group.Thus,ADNP was identified as a promising therapeutic target for the prevention and treatment of neurodevelopmental toxicity caused by general anesthetics.This study provides important insights into the mechanisms underlying social and cognitive disturbances caused by sevoflurane exposure in neonatal mice and elucidates the regulatory pathways involved.展开更多
To further improve the performance of UKF(Unscented Kalman Filter) algorithm used in BDS/SINS(BeiDou Navigation Satellite System/Strap down Inertial Navigation System), an improved GM-UKF(Gaussian Mixture Unscented Ka...To further improve the performance of UKF(Unscented Kalman Filter) algorithm used in BDS/SINS(BeiDou Navigation Satellite System/Strap down Inertial Navigation System), an improved GM-UKF(Gaussian Mixture Unscented Kalman Filter) considering non-Gaussian distribution is discussed in this paper. This new algorithm using SVD(Singular Value Decomposition) is proposed to alternative covariance square root calculation in UKF sigma point production. And to end the rapidly increasing number of Gaussian distributions, PDF(Probability Density Function) re-approximation is conducted. In principle this efficiency algorithm proposed here can achieve higher computational speed compared with traditional GM-UKF. And simulation experiment result show that, compared with UKF and GM-UKF algorithm, new algorithm implemented in BDS/SINS tightly integrated navigation system is suitable for handling nonlinear/non-Gaussian integrated navigation position calculation, for its lower computational complexity with high accuracy.展开更多
Global navigation satellite system occultation sounder (GNOS) Fengyun-3C was launched successfully on September 23, 2013, which carried GPS/BDS receiver for the first time. This provides the convenience to study the e...Global navigation satellite system occultation sounder (GNOS) Fengyun-3C was launched successfully on September 23, 2013, which carried GPS/BDS receiver for the first time. This provides the convenience to study the enhancement results of low earth orbiter satellite (LEO) to BDS precise orbit determination (POD). First the data characteristic and code observation noise of GNOS are analyzed. Then the enhancement experiments in the case of global and regional ground observation stations layout are processed with four POD schemes: BDS single system, GPS/BDS double system, BDS single system with GNOS observations, GPS/BDS double system with GNOS observations. The precision of BDS orbits and clocks are compared via overlapping arcs. Results show that in the case of global station layout the along directional precision of GEO satellite has the biggest improvement, with the improvement percentage 60%. Then the precision of cross direction and the along direction of remaining satellites shows the second biggest improvement. The orbit precision of BDS-only POD in part of observation arcs some satellite even suffers a slight decline. The root mean square (RMS) of overlapping clock difference of visible arcs in GPS/BDS POD experiments improves by 0.1 ns level. As to the experiments of regional station layout with 7 ground stations, the orbit and clock overlapping precision and orbit predicting precision are analyzed. Results show that the predicting precision of BDS GEO satellites in the along direction improves by 85%. The remaining also has a substantial improvement, with the average percentage 21.7%. RMS of overlapping clock difference of visible arcs improves by 0.5 ns level.展开更多
River discharge is a significant hydrological variable, as it represents the basin-scale integrated output of the hydrological cycle. At present, river discharge observations are usually measured at ground-based gauge...River discharge is a significant hydrological variable, as it represents the basin-scale integrated output of the hydrological cycle. At present, river discharge observations are usually measured at ground-based gauges across rivers worldwide. In some areas, however, measurements used in the practice of flood prediction and disaster prevention are either fully inaccessible or difficult to obtain in a timely and functional fashion (1)It has also been reported that the scarcity of global river discharge observations may have undermined the efforts to calculate a globally meaningful estimate of the adjusted biodiversity threat (2)The Tibetan Plateau(TP), also known as the ‘‘Asian Water Tower'.展开更多
There is increasing concern about the uncombined(UC)observation model in the field of global navigation satellite system(GNSS).Based on the global positioning system(GPS)and the third-generation BeiDou navigation sate...There is increasing concern about the uncombined(UC)observation model in the field of global navigation satellite system(GNSS).Based on the global positioning system(GPS)and the third-generation BeiDou navigation satellite system(BDS-3),this study processed the UC precision orbit determination(POD)for single and dual systems.First,a UC observation model suitable for multi-GNSS POD was derived,and the ionospheric-free(IF)combination observation model was presented.Although the ambiguity parameters of UC and IF strategies were different after reparameterization,the difference could be removed when processing ambiguity resolution,and the equivalence was proved theoretically.To demonstrate the accuracy of BDS-3 orbits fully,the observation data of approximately 1 month were selected for determining the precise orbit for global positioning system(GPS)only,BDS-3 only,and GPS/BDS-3 systems based on the UC and IF models.The orbit precision of BDS-3 satellites was validated by using metrics,including comparison with precision products released by Wuhan University,orbit boundary discontinuity,and satellite laser ranging(SLR)residuals.The results show that the orbit accuracies of the IF and UC models are almost the same,the difference in orbits is approximately several millimeters,and the clock difference is within 0.01 ns.The GPS/BDS-3 combined solution shows better accuracy compared to other solutions.The average accuracies in the R and 3D directions are approximately 4 and 15 cm,and the clock standard deviation is approximately 0.2 ns compared to external orbit product.The root mean square of SLR residuals is approximately 4 cm.展开更多
基金supported by the National Natural Science Foundation of China(82171170,81971076,82371277 to H.Z.,82101345 to L.R.L.)。
文摘A growing number of studies have demonstrated that repeated exposure to sevoflurane during development results in persistent social abnormalities and cognitive impairment.Davunetide,an active fragment of the activity-dependent neuroprotective protein(ADNP),has been implicated in social and cognitive protection.However,the potential of davunetide to attenuate social deficits following sevoflurane exposure and the underlying developmental mechanisms remain poorly understood.In this study,ribosome and proteome profiles were analyzed to investigate the molecular basis of sevoflurane-induced social deficits in neonatal mice.The neuropathological basis was also explored using Golgi staining,morphological analysis,western blotting,electrophysiological analysis,and behavioral analysis.Results indicated that ADNP was significantly down-regulated following developmental exposure to sevoflurane.In adulthood,anterior cingulate cortex(ACC)neurons exposed to sevoflurane exhibited a decrease in dendrite number,total dendrite length,and spine density.Furthermore,the expression levels of Homer,PSD95,synaptophysin,and vglut2 were significantly reduced in the sevoflurane group.Patch-clamp recordings indicated reductions in both the frequency and amplitude of miniature excitatory postsynaptic currents(mEPSCs).Notably,davunetide significantly ameliorated the synaptic defects,social behavior deficits,and cognitive impairments induced by sevoflurane.Mechanistic analysis revealed that loss of ADNP led to dysregulation of Ca^(2+)activity via the Wnt/β-catenin signaling,resulting in decreased expression of synaptic proteins.Suppression of Wnt signaling was restored in the davunetide-treated group.Thus,ADNP was identified as a promising therapeutic target for the prevention and treatment of neurodevelopmental toxicity caused by general anesthetics.This study provides important insights into the mechanisms underlying social and cognitive disturbances caused by sevoflurane exposure in neonatal mice and elucidates the regulatory pathways involved.
基金supported by Chinese National Natural ScienceFoundation (41674016 and 41274016)
文摘To further improve the performance of UKF(Unscented Kalman Filter) algorithm used in BDS/SINS(BeiDou Navigation Satellite System/Strap down Inertial Navigation System), an improved GM-UKF(Gaussian Mixture Unscented Kalman Filter) considering non-Gaussian distribution is discussed in this paper. This new algorithm using SVD(Singular Value Decomposition) is proposed to alternative covariance square root calculation in UKF sigma point production. And to end the rapidly increasing number of Gaussian distributions, PDF(Probability Density Function) re-approximation is conducted. In principle this efficiency algorithm proposed here can achieve higher computational speed compared with traditional GM-UKF. And simulation experiment result show that, compared with UKF and GM-UKF algorithm, new algorithm implemented in BDS/SINS tightly integrated navigation system is suitable for handling nonlinear/non-Gaussian integrated navigation position calculation, for its lower computational complexity with high accuracy.
基金The National Natural Science Foundation of China (41674016,41274016,41604024).
文摘Global navigation satellite system occultation sounder (GNOS) Fengyun-3C was launched successfully on September 23, 2013, which carried GPS/BDS receiver for the first time. This provides the convenience to study the enhancement results of low earth orbiter satellite (LEO) to BDS precise orbit determination (POD). First the data characteristic and code observation noise of GNOS are analyzed. Then the enhancement experiments in the case of global and regional ground observation stations layout are processed with four POD schemes: BDS single system, GPS/BDS double system, BDS single system with GNOS observations, GPS/BDS double system with GNOS observations. The precision of BDS orbits and clocks are compared via overlapping arcs. Results show that in the case of global station layout the along directional precision of GEO satellite has the biggest improvement, with the improvement percentage 60%. Then the precision of cross direction and the along direction of remaining satellites shows the second biggest improvement. The orbit precision of BDS-only POD in part of observation arcs some satellite even suffers a slight decline. The root mean square (RMS) of overlapping clock difference of visible arcs in GPS/BDS POD experiments improves by 0.1 ns level. As to the experiments of regional station layout with 7 ground stations, the orbit and clock overlapping precision and orbit predicting precision are analyzed. Results show that the predicting precision of BDS GEO satellites in the along direction improves by 85%. The remaining also has a substantial improvement, with the average percentage 21.7%. RMS of overlapping clock difference of visible arcs improves by 0.5 ns level.
基金financially supported by the Strategic Priority Research Program of Chinese Academy of Sciences (XDA20060202)the National Natural Science Foundation of China (91747201 and 41571033)
文摘River discharge is a significant hydrological variable, as it represents the basin-scale integrated output of the hydrological cycle. At present, river discharge observations are usually measured at ground-based gauges across rivers worldwide. In some areas, however, measurements used in the practice of flood prediction and disaster prevention are either fully inaccessible or difficult to obtain in a timely and functional fashion (1)It has also been reported that the scarcity of global river discharge observations may have undermined the efforts to calculate a globally meaningful estimate of the adjusted biodiversity threat (2)The Tibetan Plateau(TP), also known as the ‘‘Asian Water Tower'.
基金National Natural Science Foundation of China(Grant Nos.41674016,41874041,41704035,41904039)by State Key Laboratory of Geo-Information Engineering,NO.SKLGIE2018-M-2-1.
文摘There is increasing concern about the uncombined(UC)observation model in the field of global navigation satellite system(GNSS).Based on the global positioning system(GPS)and the third-generation BeiDou navigation satellite system(BDS-3),this study processed the UC precision orbit determination(POD)for single and dual systems.First,a UC observation model suitable for multi-GNSS POD was derived,and the ionospheric-free(IF)combination observation model was presented.Although the ambiguity parameters of UC and IF strategies were different after reparameterization,the difference could be removed when processing ambiguity resolution,and the equivalence was proved theoretically.To demonstrate the accuracy of BDS-3 orbits fully,the observation data of approximately 1 month were selected for determining the precise orbit for global positioning system(GPS)only,BDS-3 only,and GPS/BDS-3 systems based on the UC and IF models.The orbit precision of BDS-3 satellites was validated by using metrics,including comparison with precision products released by Wuhan University,orbit boundary discontinuity,and satellite laser ranging(SLR)residuals.The results show that the orbit accuracies of the IF and UC models are almost the same,the difference in orbits is approximately several millimeters,and the clock difference is within 0.01 ns.The GPS/BDS-3 combined solution shows better accuracy compared to other solutions.The average accuracies in the R and 3D directions are approximately 4 and 15 cm,and the clock standard deviation is approximately 0.2 ns compared to external orbit product.The root mean square of SLR residuals is approximately 4 cm.
