Clinical observation of Guipi Decoction Combined with non steroidal drugs on sleep in elderly patients with acute traumatic pain and Qi deficiency constitutionabortion

Objective:To explore the effect of Guipi Decoction Combined with non steroidal anti-inflammatory drugs on sleep time of elderly patients with traumatic pain and Qi deficiency constitution during hospitalization.Methods:A total of 52 elderly patients hospitalized in the orthopedic(trauma)ward of the Second Affiliated Hospital of Zhejiang Chinese Medical University from November 2020 to may 2021 were randomly divided into control group and treatment group.Patients in the control group were treated with loxoprofen sodium tablets immediately after admission,and placebo was added to loxoprofen sodium tablets from the second day of admission;The patients in the treatment group were treated with loxoprofen sodium tablets after admission.Guipi Decoction was added on the basis of loxoprofen sodium tablets from the second day of admission.Before and after admission,all patients used the TCM constitution classification judgment table to evaluate the score of qi deficiency and VAS;From the first day to the fourth day after admission,the bracelet was worn to monitor the sleep time(total sleep time,deep sleep time,light sleep time and awakening times)every night.The patients were scored by VAS after taking drugs every morning.Results:Finally 25 patients in the control group and 24 patients in the treatment group completed the experiment.There was no significant difference in gender,age,fracture location,chronic medical history VAS score and TCM Qi deficiency constitution score,between two groups at admission(P>0.05).At the time of discharge,the score of qi deficiency constitution in the treatment group was 33.724±12.634;The TCM Qi deficiency constitution score of the control group was 42.25±15.912,and there was significant difference between the two groups(P<0.05);and there was significant difference in VAS score between the two groups at discharge(P<0.05).There were significant differences in total sleep time,light sleep time,deep sleep time and night awakening times between the two groups on the second,third and fourth day of admission(P<0.05).Conclusion:1.Guipi Decoction can significantly improve the sleep time of patients with Qi deficiency acute traumatic pain.2.Guipi Decoction can not only improve the constitution of patients with Qi deficiency bias,but also improve the VAS score at discharge.

Biochemical characteristics,functions and clinical significance of cofilin

Cofilin is a low molecular weight actin-binding protein widely found in eukaryotic cells in ADF/cofilin family proteins,which has a wide range of biological effects and has gradually become a research hotspot in recent years.We review the structural characteristics of cofilin,the mechanism of regulating actin,biological functions,and the relationship with clinical diseases to explore its role in the development of cancer,nervous system diseases,osteoarthritis,heart and kidney diseases.The use of cofilin phosphorylation pathways as major action-targeting sites in the treatment of these diseases could provide a basis for the development of new drugs,such as Rho related protein kinases inhibitors netarsudil to prevent cancer metastasis,neuroligin C-terminal domain(NLG1-CTD)peptides with high affinity to inhibit LIM kinase thereby preventing nervous system diseases,grape seed proanthocyanidins to inhibit cofilin related oxidative stress in the treatment of heart and kidney diseases.