OBJECTIVE To investigate the role of active component of Isatidis Radix on insulin resistance in the diabetes mellitus rat.METHODS To induce diabetic rat model with long-term high sugar and high fat plus low-dose stre...OBJECTIVE To investigate the role of active component of Isatidis Radix on insulin resistance in the diabetes mellitus rat.METHODS To induce diabetic rat model with long-term high sugar and high fat plus low-dose streptozotocin(25 mg·kg-1).Then rats were randomly divided into 6 groups:control group,model group,rosiglitazone maleate group(0.3mg·kg-1),high(100mg·kg-1),middle(50mg·kg-1)and low(25 mg·kg-1)active component of Isatidis Radix group.Drugs were adiministered orally once a day.After four weeks,following substances were measured:serum fasting blood glucose,total cholesterol,triglycerides,high density lipoprotein,low density lipoprotein,free fatty acids,fasting insulin,insulin index,pathological observation and immunohistochemistry technology of pancreas islet.RESULTS High and middle active component of Isatidis Radix group could decrease serum FBG,TC,TG,LDL,FFA,FINS and increase serum HDL,ISI;the damage of the pancreas islet has been restoration partly.CONCLUSION Active component of Isatidis Radix could improve insulin resistance in diabetic rats,which might be related to improvement of the function of pancreas islet.展开更多
The palladium catalyzed annulation of 1-bromo-2-vinylbenzene derivatives with internal alkynes was realized for the efficient synthesis of substituted naphthalenes. A controllable aryl to vinylic 1,4-palladium migrati...The palladium catalyzed annulation of 1-bromo-2-vinylbenzene derivatives with internal alkynes was realized for the efficient synthesis of substituted naphthalenes. A controllable aryl to vinylic 1,4-palladium migration process is the key for success.展开更多
Novel antibacterial polymer coatings were prepared by a facile thiol-yne click photopolymerization of 1-propargyl-3-allYl-l,3-diazanyl-2,4-cyclopentadiene bromide （[PAIMIBr） and tetra（3-mercapto-pro- pionate）penta...Novel antibacterial polymer coatings were prepared by a facile thiol-yne click photopolymerization of 1-propargyl-3-allYl-l,3-diazanyl-2,4-cyclopentadiene bromide （[PAIMIBr） and tetra（3-mercapto-pro- pionate）pentaerythritol （PETMP） （2：1 molar ratio） using 2,2-dimethoxy-2-phenylacetophenone （DMPA） as initiator. The antibacterial activity of the coatings was tested against Staphylococcus aureus （ATCC 292130） and Escherichia coli （ATCC 25922） by the dynamic shake method. The evaluation results revealed the antibacterial polymer coatings exhibited excellent inhibitory activity against S. aureus and E. coil, especially for S. aureus.展开更多
Poly[（mercaptopropyl）methylsiloxane] （PMMS）-based antibacterial polymer coatings have been prepared through a two-step sequential thiol-ene click chemistry utilizing 1-allyl-3-decylimidazolium bromide （ADIm） as ...Poly[（mercaptopropyl）methylsiloxane] （PMMS）-based antibacterial polymer coatings have been prepared through a two-step sequential thiol-ene click chemistry utilizing 1-allyl-3-decylimidazolium bromide （ADIm） as antibacterial monomer and triallyl cyanurate （TAC） as the crosslinker. These films with different content of ADIm were characterized by thermogravimetric analysis （TGA）, dynamic mechanical analysis （DMA） and pencil hardness. It was found that the mechanical and thermal properties of these films were largely influenced by the content of ADIm in the films. Films with imidazolium bromide groups displayed excellent antimicrobial activity against Staphylococcus aureus with 100% killing efficiency.展开更多
基金The project supported by Spark Technology Project by Jiangsu Province(BE2004339)
文摘OBJECTIVE To investigate the role of active component of Isatidis Radix on insulin resistance in the diabetes mellitus rat.METHODS To induce diabetic rat model with long-term high sugar and high fat plus low-dose streptozotocin(25 mg·kg-1).Then rats were randomly divided into 6 groups:control group,model group,rosiglitazone maleate group(0.3mg·kg-1),high(100mg·kg-1),middle(50mg·kg-1)and low(25 mg·kg-1)active component of Isatidis Radix group.Drugs were adiministered orally once a day.After four weeks,following substances were measured:serum fasting blood glucose,total cholesterol,triglycerides,high density lipoprotein,low density lipoprotein,free fatty acids,fasting insulin,insulin index,pathological observation and immunohistochemistry technology of pancreas islet.RESULTS High and middle active component of Isatidis Radix group could decrease serum FBG,TC,TG,LDL,FFA,FINS and increase serum HDL,ISI;the damage of the pancreas islet has been restoration partly.CONCLUSION Active component of Isatidis Radix could improve insulin resistance in diabetic rats,which might be related to improvement of the function of pancreas islet.
基金Financial support from the National Natural Science Foundation of China （Nos. 21472212, 21572253, 21772216）, the Strategic Priority Research Program of the Chinese Academy of Sciences （No. XDB 20020100） and the Key Research Program of Frontier Science （No.QYZDY-SSW-SLH026） is acknowledged.
文摘The palladium catalyzed annulation of 1-bromo-2-vinylbenzene derivatives with internal alkynes was realized for the efficient synthesis of substituted naphthalenes. A controllable aryl to vinylic 1,4-palladium migration process is the key for success.
文摘Novel antibacterial polymer coatings were prepared by a facile thiol-yne click photopolymerization of 1-propargyl-3-allYl-l,3-diazanyl-2,4-cyclopentadiene bromide （[PAIMIBr） and tetra（3-mercapto-pro- pionate）pentaerythritol （PETMP） （2：1 molar ratio） using 2,2-dimethoxy-2-phenylacetophenone （DMPA） as initiator. The antibacterial activity of the coatings was tested against Staphylococcus aureus （ATCC 292130） and Escherichia coli （ATCC 25922） by the dynamic shake method. The evaluation results revealed the antibacterial polymer coatings exhibited excellent inhibitory activity against S. aureus and E. coil, especially for S. aureus.
文摘Poly[（mercaptopropyl）methylsiloxane] （PMMS）-based antibacterial polymer coatings have been prepared through a two-step sequential thiol-ene click chemistry utilizing 1-allyl-3-decylimidazolium bromide （ADIm） as antibacterial monomer and triallyl cyanurate （TAC） as the crosslinker. These films with different content of ADIm were characterized by thermogravimetric analysis （TGA）, dynamic mechanical analysis （DMA） and pencil hardness. It was found that the mechanical and thermal properties of these films were largely influenced by the content of ADIm in the films. Films with imidazolium bromide groups displayed excellent antimicrobial activity against Staphylococcus aureus with 100% killing efficiency.
