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间充质干细胞源性外泌体抑制创伤性脑损伤炎症反应的研究进展 被引量:4
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作者 王文瑞 黄晓飞 +4 位作者 孙田静 刘思佳 胡权 高甜 喻安永 《中国现代医学杂志》 CAS 北大核心 2022年第14期61-65,共5页
中国每年约有80万新发创伤性脑损伤(TBI)患者,其中重度患者死亡率约为27%,是青壮年死亡和致残的首要原因,为社会及家庭带来极大影响。TBI按病理、生理机制分为原发性脑损伤和继发性脑损伤。原发性脑损伤是机械性致伤因素的直接结果,而... 中国每年约有80万新发创伤性脑损伤(TBI)患者,其中重度患者死亡率约为27%,是青壮年死亡和致残的首要原因,为社会及家庭带来极大影响。TBI按病理、生理机制分为原发性脑损伤和继发性脑损伤。原发性脑损伤是机械性致伤因素的直接结果,而继发性脑损伤是在原有脑损伤基础上,颅外损伤与颅内物理、生化变化的总和,与TBI预后有重要关系。其中神经炎症反应所引起的一系列分子、细胞、组织器官水平级联反应在继发性脑损伤形成中有重要作用。目前间充质干细胞源性外泌体(MSC-Exo)作为脑损伤极具前景的治疗方式,可有效减轻神经炎症反应,改善TBI预后。该文就MSC-Exo抑制TBI后神经炎症反应的作用机制及其治疗前景作一综述,以期为后续的研究和治疗提供一定的参考。 展开更多
关键词 创伤性脑损伤 间充质干细胞 外泌体 炎症反应
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Influence of road types on road traffic accidents in northern Guizhou Province,China
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作者 tian-jing sun Si-Jia Liu +5 位作者 Fa ng-Ke Xie Xiao-Fei Huang Jian-Xiu Tao Yuan-Lan Lu Tian-Xi Zhang An-Yong Yu 《Chinese Journal of Traumatology》 CAS CSCD 2021年第1期34-38,共5页
Purpose The increasing number of deaths due to road traffic accidents(RTAs)has attracted global attention.However,the influence of road types is rarely considered in the study of RTAs.This study evaluates the influenc... Purpose The increasing number of deaths due to road traffic accidents(RTAs)has attracted global attention.However,the influence of road types is rarely considered in the study of RTAs.This study evaluates the influence of different road types in RTAs in northern Guizhou to provide a basis for the formulation of evidence-based policies and measures.Methods We obtained the data from the Zunyi Traffic Management Data Platform for the years 2009–2018.The mortality rates of RTAs were calculated.Descriptive methods and Chi-square tests were used to analyze the characteristics of road traffic collisions on different road types.We also examined the associations between the mortality rate per 10,000 vehicles and the growth of per capital gross domestic product(GDP)with Spearman’s rank correlation analysis.According to the passing volume and the infrastructure,we defined different types of roads,like administrative road,functional road,general urban road and urban expressway.Results In 2012,the traffic mortality rate of administrative roads was 8.9 per 100,000 people,and the mortality rate of functional roads was 7.4 per 100,000 people,which decreased in 2018 to 6.1 deaths per 100,000 people and 5.2 deaths per 100,000 people,respectively.The mortality rate per 10,000 vehicles reached the highest level in 2011(28.8 per 10,000 vehicles and 22.5 per 10,000 vehicles on administrative and functional roads,respectively).The death rate of county roads was the highest among administrative roads(χ^(2)=17.389,p<0.05)and that of fourth-class roads was the highest among functional roads(χ^(2)=21.785,p<0.05).The mortality rate per 10,000 vehicles was negatively correlated with per capital GDP.Conclusion Although our research shows that RTAs in northern Guizhou have steadily declined in recent years,the range of decline is relatively small.Many measures and sustainable efforts are needed to control road traffic death and accelerate the progress in road traffic safety in northern Guizhou. 展开更多
关键词 Road traffic accidence Road types TREATMENT Injury prevention
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