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Pathological mechanism of immune disorders in diabetic kidney disease and intervention strategies
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作者 Tong Zhou Yi-Lin Fang +1 位作者 tian-tian tian Gui-Xia Wang 《World Journal of Diabetes》 SCIE 2024年第6期1111-1121,共11页
Diabetic kidney disease is one of the most severe chronic microvascular complications of diabetes and a primary cause of end-stage renal disease.Clinical studies have shown that renal inflammation is a key factor dete... Diabetic kidney disease is one of the most severe chronic microvascular complications of diabetes and a primary cause of end-stage renal disease.Clinical studies have shown that renal inflammation is a key factor determining kidney damage during diabetes.With the development of immunological technology,many studies have shown that diabetic nephropathy is an immune complex disease,and that most patients have immune dysfunction.However,the immune response associated with diabetic nephropathy and autoimmune kidney disease,or caused by ischemia or infection with acute renal injury,is different,and has a complicated pathological mechanism.In this review,we discuss the pathogenesis of diabetic nephropathy in immune disorders and the intervention mechanism,to provide guidance and advice for early intervention and treatment of diabetic nephropathy. 展开更多
关键词 Diabetic kidney disease Immune disorders Pathological mechanism Intervention strategy Kidney damage Diabetic nephropathy INFLAMMASOME IMMUNOGLOBULIN
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