Adjustable ion energy barrier for reliable memristive neuromorphic systems

With the rapid development of artificial intelligence and the processing of large-scale data,the demand for low-power and high-speed computing has become increasingly crucial[1].Neuromorphic computing,which mimics the neural structure of the human brain,offers a promising solution to overcome the limitations of traditional von Neumann architecture[2,3].

De Novo Design of Polymeric Carrier to Photothermally Release Singlet Oxygen for Hypoxic Tumor Treatment

Intratumoral hypoxia extremely limits the clinic applications of photodynamic therapy(PDT).Endoperoxides allow thermally releasing singlet oxygen(1O_(2))in a defned quantity and ofer promising opportunities for oxygen-independent PDT treatment of hypoxic tumors.However,previous composite systems by combining endoperoxides with photothermal reagents may result in unpredicted side efects and potential harmful impacts during therapy in vivo.Herein,we de novo design an all-in-one polymer carrier,which can photothermally release 1O_(2).Te strategy has been demonstrated to efectively enhance the production of 1O_(2) and realize the photodamage in vitro,especially in hypoxic environment.Additionally,the polymer carrier accumulates into tumor afer intravenous injection via the enhanced permeation and retention efects and accelerates the oxygen-independent generation of 1O_(2) in tumors.Te oxidative damage results in good inhibitory efect on tumor growth.Realization of the strategy in vivo paves a new way to construct photothermal-triggered oxygen-independent therapeutic platform for clinical applications.

Flexible high-resolution micro-LED display device with integrations of transparent,conductive,and highly elastic hydrogel

Computer vision techniques are real-time,immersive,and perceptual human-computer interaction technology.Excellent display effect,dynamic surface flexibility,and safe bio-adhesion are essential for various human–computer interaction applications,such as metaverse interfaces,skin-like sensors,and optoelectronic medical devices.However,realizing the flexible matching of inorganic optoelectronic devices and organisms remains a grand challenge for current display technologies.Here,we proposed a novel strategy by combining the optoelectronic advantages of inorganic micro light emitting diode(micro-LED)display and the extraordinary mechanical/biological compatibility of organic materials to overcome this challenge.A highly elastic(greater than 2000%strain),highly transparent(94%visible light transmittance),biocompatible conductive hydrogel composite electrode layer was fabricated.For the first time,we realized the on-chip electrical interconnection of 4900 LED units to form a blue-green light display patch with high resolution(264 PPI),low power consumption(4.4 mW)and adaptive surface attachment.This work demonstrates an integrated scheme and potential applications of flexible high-resolution microdisplays,such as wearable fullcolor micro-LED smart curved display devices and conformable biomedical monitoring systems.