Corporate ethics and sustainable development are receiving increasing attention in today’s society.More and more companies are realizing that ethical and sustainable development is not only a requirement for fulfilli...Corporate ethics and sustainable development are receiving increasing attention in today’s society.More and more companies are realizing that ethical and sustainable development is not only a requirement for fulfilling social responsibility but also a key factor for achieving long-term growth and sustainable competitive advantage.As a result,companies are integrating ethics and sustainability into their strategies,decisions,and operations to achieve both business success and social benefit.However,some companies shout sustainability and environmental protection slogans;the actual practice differs from the claim.This paper combined the planning and actual data of the Coca-Cola Company and found that the Coca-Cola Company was suspected of greenwashing.While Coca-Cola does contribute to the environment,there is a difference between what it does and what it says.As for the possibility of this problem,the article also makes a relative solution and assessment.展开更多
Ultrasound (US) has become one of the most commonly performed imaging modalities in clinical practice. It is a rapidly evolving technology with certain advantages and with unique challenges that include low imaging qu...Ultrasound (US) has become one of the most commonly performed imaging modalities in clinical practice. It is a rapidly evolving technology with certain advantages and with unique challenges that include low imaging quality and high variability. From the perspective of image analysis, it is essential to develop advanced automatic US image analysis methods to assist in US diagnosis and/or to make such assessment more objective and accurate. Deep learning has recently emerged as the leading machine learning tool in various research fields, and especially in general imaging analysis and computer vision. Deep learning also shows huge potential for various automatic US image analysis tasks. This review first briefly introduces several popular deep learning architectures, and then summarizes and thoroughly discusses their applications in various specific tasks in US image analysis, such as classification, detection, and segmentation. Finally, the open challenges and potential trends of the future application of deep learning in medical US image analysis are discussed.展开更多
Oxidation of petroleum-based byproduct dicyclopentadiene derived diformyltricyclodecanes(DFTD) to dicarboxyltriclodecanesacids(DCTDA) was conducted under catalyst-free and ultra-low temperature conditions with O2 as o...Oxidation of petroleum-based byproduct dicyclopentadiene derived diformyltricyclodecanes(DFTD) to dicarboxyltriclodecanesacids(DCTDA) was conducted under catalyst-free and ultra-low temperature conditions with O2 as oxidant. In the perspective of industry process, oxygen pressure and contents, solvent and raw material initial concentrations were screened to evaluate their influence on DCTDA generation. Results indicate that DFTD oxidation can occur rather easily under no-catalyst and ultra-low temperature conditions with O2 as oxidant. Oxygen content and pressure had positive effect on DCTDA production, γ-valerolactone(GVL) behaved best on DFTD generation in dynamics, while methanol could be used as a protective solvent to preserve DFTD.Besides, the existence of water in solvent was not beneficial to DCTDA production because of poor DFTD compatibility with water. The mechanisms of O2 and solvent influence on DCTDA generation were discussed. Meanwhile,the oxidation route of DFTD–Intermediate–DCTDA was proposed. The present work exhibits the valued potential of DFTD, which will have a positive effect on high added value of petroleum based by-products.展开更多
Tissue elasticity and viscosity are always associated with pathological changes.As a new imaging method,ultrasound vibro-acoustic imaging is developed for quantitatively measuring tissue elasticity and viscosity which...Tissue elasticity and viscosity are always associated with pathological changes.As a new imaging method,ultrasound vibro-acoustic imaging is developed for quantitatively measuring tissue elasticity and viscosity which have important significance in early diagnosis of cancer.This paper developed an ultrasound vibro-acoustic imaging research platform mainly consisting of excitation part and detection part.The excitation transducer was focused at one location within the medium to generate harmonic vibration and shear wave propagation,and the detection transducer was applied to detect shear wave at other locations along shear wave propagation path using pulse-echo method.The received echoes were amplified,filtered,digitized and then processed by Kalman filter to estimate the vibration phase.According to the phase changes between different propagation locations,we estimated the shear wave speed,and then used it to calculate the tissue elasticity and viscosity.Preliminary phantom experiments based on this platform show results of phantom elasticity and viscosity close to literature values.Upcoming experiments are now in progress to obtain quantitative elasticity and viscosity in vitro tissue.展开更多
T rays is sensitive to covalently cross linked proteins and can be used to probe unique dynamic properties of water surrounding a protein.In this paper,we demonstrate the unique abeorption properties of the dynamic hy...T rays is sensitive to covalently cross linked proteins and can be used to probe unique dynamic properties of water surrounding a protein.In this paper,we demonstrate the unique abeorption properties of the dynamic hydnation shells deternined by hemagglutinin(HA)protein in ter-ahertz frequency.We study the changes arising fom diferent concentrations in detail and show that nonlinear absorption coefficient is induced by the dynamic hydration water.The binary and ternary component model were used to interpret the nonlinearity absorption behaviors and predict the thickness of the hydration shells around the HA protein in aquous phase.展开更多
Being an emerging body-shaping technology of fat cell disruption,high-intensity focused ultrasound has been investigated intensively in recent years for its favorable natures such as painlessness,safety and noninvasio...Being an emerging body-shaping technology of fat cell disruption,high-intensity focused ultrasound has been investigated intensively in recent years for its favorable natures such as painlessness,safety and noninvasion.One of the major problems for the technology,however,is the overheating of transducers.In this study,we modified the transducer design in order to solve the overheating problem.We simulated the performance of the modified design by finite element analysis and fabricated the newly designed transducer.By measuring the actual performance data,we proved that the new design can effectively reduce temperature rise while keeping the acoustic intensity field unaffected.展开更多
Therapeutic nanoparticles are designed to enhance efficacy,real-time monitoring,targeting accuracy,biocompatibility,biodegradability,safety,and the synergy of diagnosis and treatment of diseases by leveraging the uniq...Therapeutic nanoparticles are designed to enhance efficacy,real-time monitoring,targeting accuracy,biocompatibility,biodegradability,safety,and the synergy of diagnosis and treatment of diseases by leveraging the unique physicochemical and biological properties of well-developed bio-nanomaterials.Recently,bio-inspired metal nanoclusters(NCs)consisting of several to roughly dozens of atoms(<2 nm)have attracted increasing research interest,owing to their ultrafine size,tunable fluorescent capability,good biocompatibility,variable metallic composition,and extensive surface bio-functionalization.Hybrid coreeshell nanostructures that effectively incorporate unique fluorescent inorganic moieties with various biomolecules,such as proteins(enzymes,antigens,and antibodies),DNA,and specific cells,create fluorescently visualized molecular nanoparticle.The resultant nanoparticles possess combinatorial properties and synergistic efficacy,such as simplicity,active bio-responsiveness,improved applicability,and low cost,for combination therapy,such as accurate targeting,bioimaging,and enhanced therapeutic and biocatalytic effects.In contrast to larger nanoparticles,bio-inspired metal NCs allow rapid renal clearance and better pharmacokinetics in biological systems.Notably,advances in nanoscience,interfacial chemistry,and biotechnologies have further spurred researchers to explore bio-inspired metal NCs for therapeutic purposes.The current review presents a comprehensive and timely overview of various metal NCs for various therapeutic applications,with a special emphasis on the design rationale behind the use of biomolecules/cells as the main scaffolds.In the different hybrid platform,we summarize the current challenges and emerging perspectives,which are expected to offer in-depth insight into the rational design of bio-inspired metal NCs for personalized treatment and clinical translation.展开更多
文摘Corporate ethics and sustainable development are receiving increasing attention in today’s society.More and more companies are realizing that ethical and sustainable development is not only a requirement for fulfilling social responsibility but also a key factor for achieving long-term growth and sustainable competitive advantage.As a result,companies are integrating ethics and sustainability into their strategies,decisions,and operations to achieve both business success and social benefit.However,some companies shout sustainability and environmental protection slogans;the actual practice differs from the claim.This paper combined the planning and actual data of the Coca-Cola Company and found that the Coca-Cola Company was suspected of greenwashing.While Coca-Cola does contribute to the environment,there is a difference between what it does and what it says.As for the possibility of this problem,the article also makes a relative solution and assessment.
基金the National Natural Science Foundation of China (61571304, 81571758, and 61701312)the National Key Research and Development Program of China (2016YFC0104703)+1 种基金the Medical Scientific Research Foundation of Guangdong Province, China (B2018031)the Shenzhen Peacock Plan (KQTD2016053112051497).
文摘Ultrasound (US) has become one of the most commonly performed imaging modalities in clinical practice. It is a rapidly evolving technology with certain advantages and with unique challenges that include low imaging quality and high variability. From the perspective of image analysis, it is essential to develop advanced automatic US image analysis methods to assist in US diagnosis and/or to make such assessment more objective and accurate. Deep learning has recently emerged as the leading machine learning tool in various research fields, and especially in general imaging analysis and computer vision. Deep learning also shows huge potential for various automatic US image analysis tasks. This review first briefly introduces several popular deep learning architectures, and then summarizes and thoroughly discusses their applications in various specific tasks in US image analysis, such as classification, detection, and segmentation. Finally, the open challenges and potential trends of the future application of deep learning in medical US image analysis are discussed.
基金Supported by the Research Foundation of China University of Petroleum,-Beijing at Karamay(YJ2018B02006)the Chinese Government “Thousand Talent” Program(Y42H291501).
文摘Oxidation of petroleum-based byproduct dicyclopentadiene derived diformyltricyclodecanes(DFTD) to dicarboxyltriclodecanesacids(DCTDA) was conducted under catalyst-free and ultra-low temperature conditions with O2 as oxidant. In the perspective of industry process, oxygen pressure and contents, solvent and raw material initial concentrations were screened to evaluate their influence on DCTDA generation. Results indicate that DFTD oxidation can occur rather easily under no-catalyst and ultra-low temperature conditions with O2 as oxidant. Oxygen content and pressure had positive effect on DCTDA production, γ-valerolactone(GVL) behaved best on DFTD generation in dynamics, while methanol could be used as a protective solvent to preserve DFTD.Besides, the existence of water in solvent was not beneficial to DCTDA production because of poor DFTD compatibility with water. The mechanisms of O2 and solvent influence on DCTDA generation were discussed. Meanwhile,the oxidation route of DFTD–Intermediate–DCTDA was proposed. The present work exhibits the valued potential of DFTD, which will have a positive effect on high added value of petroleum based by-products.
基金This work was supported by the National Natural Science Foundation of China(Grant No.81000637)the Key Program of National Natural Science Foundation of China(Grant No.61031003)Shenzhen-HK innovative circle project(Grant No.ZYB200907090125A).
文摘Tissue elasticity and viscosity are always associated with pathological changes.As a new imaging method,ultrasound vibro-acoustic imaging is developed for quantitatively measuring tissue elasticity and viscosity which have important significance in early diagnosis of cancer.This paper developed an ultrasound vibro-acoustic imaging research platform mainly consisting of excitation part and detection part.The excitation transducer was focused at one location within the medium to generate harmonic vibration and shear wave propagation,and the detection transducer was applied to detect shear wave at other locations along shear wave propagation path using pulse-echo method.The received echoes were amplified,filtered,digitized and then processed by Kalman filter to estimate the vibration phase.According to the phase changes between different propagation locations,we estimated the shear wave speed,and then used it to calculate the tissue elasticity and viscosity.Preliminary phantom experiments based on this platform show results of phantom elasticity and viscosity close to literature values.Upcoming experiments are now in progress to obtain quantitative elasticity and viscosity in vitro tissue.
基金We gratefully acknowledge partial financial support for this work from the National Natural Science Foundation of China(No.61205092)Guangdong Natural Science Foundation(No.S2012040007668)+1 种基金Foundation for Distinguished Young Talents in Higher Education of Guangdong,China(No.2012LYM_0116)Special Foundation of New Industries Development,Shenzhen(ZDSY20120612094855904).
文摘T rays is sensitive to covalently cross linked proteins and can be used to probe unique dynamic properties of water surrounding a protein.In this paper,we demonstrate the unique abeorption properties of the dynamic hydnation shells deternined by hemagglutinin(HA)protein in ter-ahertz frequency.We study the changes arising fom diferent concentrations in detail and show that nonlinear absorption coefficient is induced by the dynamic hydration water.The binary and ternary component model were used to interpret the nonlinearity absorption behaviors and predict the thickness of the hydration shells around the HA protein in aquous phase.
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.10904093 and 61031003)the Science and Technology Grant Scheme funds from Shenzhen Government(No.08CXY-23).
文摘Being an emerging body-shaping technology of fat cell disruption,high-intensity focused ultrasound has been investigated intensively in recent years for its favorable natures such as painlessness,safety and noninvasion.One of the major problems for the technology,however,is the overheating of transducers.In this study,we modified the transducer design in order to solve the overheating problem.We simulated the performance of the modified design by finite element analysis and fabricated the newly designed transducer.By measuring the actual performance data,we proved that the new design can effectively reduce temperature rise while keeping the acoustic intensity field unaffected.
基金support from National Natural Science Foundation of China(Grant No.11802066)Science and Technology Innovation Committee of Shenzhen(JCYJ20170818091601315,China)support from the China Postdoctoral Science Foundation(2019M01294501)。
文摘Therapeutic nanoparticles are designed to enhance efficacy,real-time monitoring,targeting accuracy,biocompatibility,biodegradability,safety,and the synergy of diagnosis and treatment of diseases by leveraging the unique physicochemical and biological properties of well-developed bio-nanomaterials.Recently,bio-inspired metal nanoclusters(NCs)consisting of several to roughly dozens of atoms(<2 nm)have attracted increasing research interest,owing to their ultrafine size,tunable fluorescent capability,good biocompatibility,variable metallic composition,and extensive surface bio-functionalization.Hybrid coreeshell nanostructures that effectively incorporate unique fluorescent inorganic moieties with various biomolecules,such as proteins(enzymes,antigens,and antibodies),DNA,and specific cells,create fluorescently visualized molecular nanoparticle.The resultant nanoparticles possess combinatorial properties and synergistic efficacy,such as simplicity,active bio-responsiveness,improved applicability,and low cost,for combination therapy,such as accurate targeting,bioimaging,and enhanced therapeutic and biocatalytic effects.In contrast to larger nanoparticles,bio-inspired metal NCs allow rapid renal clearance and better pharmacokinetics in biological systems.Notably,advances in nanoscience,interfacial chemistry,and biotechnologies have further spurred researchers to explore bio-inspired metal NCs for therapeutic purposes.The current review presents a comprehensive and timely overview of various metal NCs for various therapeutic applications,with a special emphasis on the design rationale behind the use of biomolecules/cells as the main scaffolds.In the different hybrid platform,we summarize the current challenges and emerging perspectives,which are expected to offer in-depth insight into the rational design of bio-inspired metal NCs for personalized treatment and clinical translation.
