Glutamine is an importantα-amino acid that provides carbon and nitrogen sources for the biosynthesis of nucleotides,proteins,and lipids.It also generates metabolites that fuel the tricarboxylic acid cycle and maintai...Glutamine is an importantα-amino acid that provides carbon and nitrogen sources for the biosynthesis of nucleotides,proteins,and lipids.It also generates metabolites that fuel the tricarboxylic acid cycle and maintain intracellular redox balances.Malignant cells have a heightened metabolic dependence on glutamine to support incessant tumor growth and mitigate tumor microenvironmental stresses including hypoxia,nutrient depletion.展开更多
基金Supported by the Richard W.TeLinde Research Program,The Johns Hopkins University(USA).
文摘Glutamine is an importantα-amino acid that provides carbon and nitrogen sources for the biosynthesis of nucleotides,proteins,and lipids.It also generates metabolites that fuel the tricarboxylic acid cycle and maintain intracellular redox balances.Malignant cells have a heightened metabolic dependence on glutamine to support incessant tumor growth and mitigate tumor microenvironmental stresses including hypoxia,nutrient depletion.
