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Development of 3He-filled linear position-sensitive detector for neutron scattering instruments at CSNS
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作者 Lin Zhu Jian-rong Zhou +21 位作者 Xin-feng Jiang Xiao-juan Zhou Wen-qin Yang Yuan-Guang Xia liang Xiao Hong Luo Bei-ju Guan Yan-feng Wang Hong Xu Pei-xun Shen Hai-yun Teng Jia-jie Li Gui-an Yang Ju-ping Xu Huai-can Chen Song-lin Wang Jian Zhuang Jun-rong Zhang Wen Yin Zhi-jia Sun Yuan-bo Chen tianjiao liang 《Radiation Detection Technology and Methods》 CSCD 2023年第1期100-106,共7页
Background Helium-3-filled linear position-sensitive detectors(LPSDs)have been widely applied to neutron scattering instruments in recent decades owing to the high detection efficiency,the excellent neutron/gamma disc... Background Helium-3-filled linear position-sensitive detectors(LPSDs)have been widely applied to neutron scattering instruments in recent decades owing to the high detection efficiency,the excellent neutron/gamma discrimination,and the ability to construct the detector with large area coverage.More than 65%of neutron instruments at the China Spallation Neutron Source(CSNS)require ^(3)He LPSDs for the building of the detector system.The detector of a neutron scattering instrument is normally an array detector composed of a large number of ^(3)He LPSDs.However,no appropriate substitute detector is available for the ^(3)He LPSD for operation over a short period,and its specifications need to be customized to satisfy the requirements of different instruments.This necessitates the development of ^(3)He LPSDs with different specifications for building and upgrading the detectors of neutron scattering instruments at CSNS.Purpose To meet the general requirements specified by the neutron instruments at CSNS,a ^(3)He LPSD was developed and its performances were investigated by using the neutron beam.Methods The neutron beam experiments for this ^(3)He LPSD,including measurements of counting rate plateau curve,position calibration,and position resolution along the tube path,were carried out at the beamline-20 of CSNS.To evaluate its performance in the instrument operation,a detector module made of this ^(3)He LPSD has been installed in the multi-physics instrument(MPI),and the comparison test with the commercial ^(3)He LPSD has been conducted at neutron scattering experiments.Results and conclusion The experimental measurements for this ^(3)He LPSD based on the neutron beam showed that it satisfies the requirements for use in neutron scattering instruments.It reaches a plateau slope of 2.6%/100 V with a plateau range from 1750 to 1950 V and attained a minimal position resolution of 5.3 mm(FWHM),superior to the one achieved by the commercial ^(3)He LPSD.In addition,this ^(3)He LPSD detector module applied to the MPI has been working steadily for half of year and is available for use in experiments.These results provide a sound basis for the subsequent construction and upgradation of the detector of neutron scattering instruments at CSNS. 展开更多
关键词 Counting rate CSNS LPSD Plateau curve Position resolution
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BNCT中子源的研发现况与展望 被引量:4
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作者 傅世年 梁天骄 陈和生 《科学通报》 EI CAS CSCD 北大核心 2022年第14期1471-1478,共8页
硼中子俘获疗法(boron neutron capture therapy,BNCT)治疗癌症是一种典型的二元疗法,它既需要高品质的中子束,又需要高靶向性的含硼药物,两者缺一不可、密切配合,方可对肿瘤实现细胞级精准的靶向杀伤.BNCT治疗方法显著的优越性的背后,... 硼中子俘获疗法(boron neutron capture therapy,BNCT)治疗癌症是一种典型的二元疗法,它既需要高品质的中子束,又需要高靶向性的含硼药物,两者缺一不可、密切配合,方可对肿瘤实现细胞级精准的靶向杀伤.BNCT治疗方法显著的优越性的背后,是对中子源和载硼药物特性的很高要求.含硼药物研究涉及多学科,包括放射学、化学、医学、药学、生物学和物理学等.本文主要讨论BNCT中子源的问题.首先,介绍BNCT对中子束特性要求的国际标准,回顾几十年来BNCT中子源发展的困难所在;然后,展现近年来加速器中子源异军突起、开创BNCT新未来的前景,明确研发中的核心技术;最后,报告我国在此领域前沿研究的最新成果及其发展展望. 展开更多
关键词 硼中子俘获疗法(BNCT) 强流质子加速器 中子源 载硼靶向药物
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偶联阿霉素^(10)B_(4)C纳米颗粒的制备及其在联合硼中子俘获治疗/化疗中的应用 被引量:1
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作者 张玉财 周琪怡 +3 位作者 陈俊阳 童剑飞 梁天骄 赵利 《科学通报》 EI CAS CSCD 北大核心 2022年第14期1546-1554,共9页
硼中子俘获治疗(boron neutron capture therapy,BNCT)是一种二元靶向肿瘤治疗方法,研发新型多功能硼药是提高BNCT疗效的关键.本研究通过对^(10)B_(4)C纳米颗粒进行表面化学修饰制备了一种新型多功能纳米硼药.首先在^(10)B_(4)C纳米颗... 硼中子俘获治疗(boron neutron capture therapy,BNCT)是一种二元靶向肿瘤治疗方法,研发新型多功能硼药是提高BNCT疗效的关键.本研究通过对^(10)B_(4)C纳米颗粒进行表面化学修饰制备了一种新型多功能纳米硼药.首先在^(10)B_(4)C纳米颗粒表面接枝超支化聚丙三醇(PG),然后通过pH敏感的腙键偶联阿霉素(DOX),得到纳米硼药^(10)B_(4)C-PG-DOX.PG层的高亲水性使^(10)B_(4)C-PG-DOX在水溶液中具有良好的分散性和稳定性;而DOX单元的引入使^(10)B_(4)C-PG-DOX带有正电荷并赋予纳米颗粒一定的亲脂性,从而更容易被肿瘤细胞内吞.当^(10)B_(4)C-PG-DOX的浓度为10μg^(10)B/mL时,平均每个4T1小鼠乳腺癌细胞中^(10)B原子数高达(4.92±0.36)×10^(11)个.^(10)B_(4)C-PG-DOX进入4T1细胞后,主要分布在溶酶体中,而溶酶体的酸性环境有利于腙键断裂并释放DOX,从而对细胞产生化疗效应.结合加速器热中子照射,^(10)B_(4)C-PG-DOX对4T1细胞展现出良好的BNCT/化学联合治疗效果.因此,^(10)B_(4)C-PG-DOX是一种具有潜在应用价值的多功能纳米硼药. 展开更多
关键词 碳化硼 阿霉素 纳米硼药 硼中子俘获治疗 化疗
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Design of imaging system for CSNS near-target beam diagnostics
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作者 Zhirong Zeng Shanhua Zhang +8 位作者 Weilin Cheng Quanzhi Yu Shaohong Wei Bin Zhou Donghui Zhu Quan Ji Aijun Zeng tianjiao liang Yuanbo Chen 《Radiation Detection Technology and Methods》 2018年第2期38-46,共9页
Introduction China Spallation Neutron Source(CSNS)is an accelerator-based pulsed neutron source which produces neutron with spallation reaction induced by proton bombarding tungsten target.With increasing beam powers ... Introduction China Spallation Neutron Source(CSNS)is an accelerator-based pulsed neutron source which produces neutron with spallation reaction induced by proton bombarding tungsten target.With increasing beam powers and influences on target,near-target monitoring becomes extreme necessary.In this situation,an optical imaging system for proton beam diagnostics and monitoring near the target is being developed at CSNS,which can provide real-time images of the beam on target and beam distribution information.Target imaging system design and development In the design of CSNS target imaging system,coating of Cr^(3+):Al_(2)O_(3) is used to convert particle radiation into emission light.According to the geometry limits of CSNS target station,a special optical system was designed and fabricated to collect the emission light.When the proton beams strike on the target,the coating on the target will be excited,emitting luminescence at the same time.The mirrors and lenses of the optical system image the distribution of emission light into a radiation-hard imaging fiber,which transmits the images to the GigE camera located at low-dose area outside of the target station.Software was written on the LabView platform to control the camera and analyze the images on line.Mock-up of the imaging system was manufactured to test and evaluate the performances of the system.Some important characteristics of the system were obtained and studied.Conclusion Tests on the mock-up of the system present reliably expectation for beam diagnostics.The imaging system has been installed at CSNS recently.More work will be continued to improve the properties of the system. 展开更多
关键词 Beam diagnostics Beam profile Imaging system Luminescent coating
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Measurements and characteristics of Al_(2)O_(3):Cr^(3+) coating for the proton beam imaging system
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作者 Zhirong Zeng Quanzhi Yu +4 位作者 Shaohong Wei Bin Zhou Quan Ji tianjiao liang Yuanbo Chen 《Radiation Detection Technology and Methods》 2017年第1期54-60,共7页
Introduction To set up an online proton beam diagnostic system near the neutron production target of China Spallation Neutron Source(CSNS),a luminescence coating sprayed on the target windowand a corresponding optic s... Introduction To set up an online proton beam diagnostic system near the neutron production target of China Spallation Neutron Source(CSNS),a luminescence coating sprayed on the target windowand a corresponding optic system were fabricated.In the work,the fabrication of Al_(2)O_(3):Cr^(3+) coating was explored.Measurements on the sprayed samples were performed to analyze the characteristics of the Al_(2)O_(3):Cr^(3+) coating.Fabrication and tests of coating samples Three kinds of powders with different Cr concentrations were used to fabricate the luminescence coating samples.The flame spraying,plasma spraying and D-gun spraying processes were explored.Photoluminescence(PL),X-ray diffraction(XRD),scanned electron mirror(SEM)and radioluminescence experiment by 300 MeV deuterium beam were carried out to analyze and characterize the samples.Results The emission spectrum excited by 532-nm laser has two obvious peaks at 692.9 nm and 694.3 nm.The samples by flame spraying process with the powders obtained from melting method show higher luminescence intensity than the samples by plasma spraying process.It is observed that the luminescence intensity has some relationships with the alpha phase in the samples,which is deduced from the XRD and photoluminescence tests results.A lower temperature during the flame spraying process will help to keep more alpha phase in the material.The selected four samples show successful fluoresced results in the radioluminescence experiment.Conclusions The luminescence intensity of the coating is improved greatly by the studies on the fabrication process and the characteristics of the samples.The luminescence coating used in beam diagnostics will be fabricated by the confirmed technical process.More works will be continued to improve the characteristics of the luminescence light by controlling Cr concentration and annealing in 1200∼2000℃ environment in the future. 展开更多
关键词 Al_(2)O_(3):Cr^(3+)luminescence coating Beam diagnostics Spallation target
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