The Four Most Basic Elements In Machine Cognition

ion"from the symbolic school of artificial intelligence,"association"from the connectionist school,and"interaction"from the behaviorist school,the core of cognition is established on the shoulders of such scientific giants such as Schrodinger,Turing and Wiener.Soft and hard-structured ware interact.Cognitive machine can comprise heterogeneous hard-structured ware,such as field programmable gate arrays(FPGAs),data processing units(DPUs),central processing units(CPUs),graphics processing units(GPUs),tensor processing units(TPUs),and memory.It can also be implanted with the"Baby Cognitive Nucleus"which is hard-structured ware genetically inherited and naturally evolved to form the embodied machine.Then the hard-structured ware is parasitized by rich,multi-scale soft-structured ware.By regulating matter and energy through soft-structured ware,machines produce orderly events,form coordinated and orderly thinking activities.The heterogeneous sensors configured by the machine and the speed of thinking will no longer be trapped by the extreme values of biochemical parameters of carbon-based organisms but will be able to perceive through multi-channel cross-modal means,carry out intense thinking,and maintain cognitive continuity with memory.To generate computational and memory intelligence in cognitive space which can bootstrap,self-reuse and self-replicate,imagination and creativity are improved through memory-constrained computing.The new generation of artificial intelligence will leap beyond mechanized mathematics to automation in thinking and self-driven growth of cognition,and the thinking in the cognitive space and the behavior in the physical space verify each other,from the dialogue Turing test to the embodied Turing test.Humans have entered the intelligent era of human-machine co-creation with cognitive machines iteratively inventing,discovering,and creating alongside scientists,engineers,and skilled craftsmen,each wise in its way,improving thinking ability,and amplifying human energy.

Multiple evaluations of atmospheric behavior between Criegee intermediates and HCHO: Gas-phase and air-water interface reaction

Given the high abundance of water in the atmosphere,the reaction of Criegee intermediates(CIs)with(H_(2)O)_(2) is considered to be the predominant removal pathway for CIs.However,recent experimental findings reported that the reactions of CIs with organic acids and carbonyls are faster than expected.At the same time,the interface behavior between CIs and carbonyls has not been reported so far.Here,the gas-phase and air-water interface behavior between Criegee intermediates and HCHO were explored by adopting high-level quantum chemical calculations and Born-Oppenheimer molecular dynamics(BOMD)simulations.Quantum chemical calculations evidence that the gas-phase reactions of CIs+HCHO are submerged energy or low energy barriers processes.The rate ratios speculate that the HCHO could be not only a significant tropospheric scavenger of CIs,but also an inhibitor in the oxidizing ability of CIs on SO_(x) in dry and highly polluted areas with abundant HCHO concentration.The reactions of CH_(2)OO with HCHO at the droplet’s surface follow a loop structure mechanism to produce i)SOZ(■),ii)BHMP(HOCH_(2)OOCH_(2)OH),and iii)HMHP(HOCH_(2)OOH).Considering the harsh reaction conditions between CIs and HCHO at the interface(i.e.,the two molecules must be sufficiently close to each other),the hydration of CIs is still their main atmospheric loss pathway.These results could help us get a better interpretation of the underlying CIs-aldehydes chemical processes in the global polluted urban atmospheres.

Spontaneous regression of tumor in a girl with optic pathway glioma with diencephalic syndrome

To the editor:A 6-month-old girl presented with poor appetite but no vomiting or other gastrointestinal symptom.There was no significant increase in her body weight for 2 months.Her birth weight was 3.4 kg.She also had horizontal nystagmus 2 days before her initial visit.Physical examination showed that the patient had bilateral horizontal nystagmus and left esotropia.Poor visual acuity was found on the left side.

Impact of Water Molecules on the Isomerization of CH3S（OH）CH2 to CH3S（O）CH3： A Computational Investigation

The isomerization of CH3S（OH）CH2 to CH3S（O）CH3 in the absence and presence of water has been investigated at the G3XMP2//B3LYP/6-311 ＋ G（2df, p） level. The naked isomerization, the reaction without water, gives the high barrier height （21.56 kcal.mol^-1）. Three models are constructed to describe the water influence on the isomerization, that is, water molecules are the catalyst and the microsolvation, and water molecules act as the catalyst and microsolvation simultaneously. Our results show that the isomerization barrier heights of CH3S（OH）CH2 to CH3S（O）CH3 are reduced by 12.32, 11.04, and 7.80 kcal.mol^-1, respectively, when one, two, and three water molecules are performed as catalyst, in contrast to the naked isomerization. Moreover, the rate constants of the isomerization are calculated using the transition state theory with the Wigner tunneling correction over the temperature range of 240-425 K. We find that the rate constant of a single water molecule as the catalyst is 1.58 times larger than the naked isomerization at 325 K, whereas it is slower by 6 orders of magnitude when water molecule serves as the microsolvation at 325 K, compared to naked reaction. So the water-catalyzed isomerization of CH3S（OH）CH2 to CH3S（O）CH3 is predicted to be the key role in lowering the activation energy. The isomerization involving water molecules acting as mierosolvation is unfavorable under atmospheric conditions.

Volumetric Imaging of Neural Activity by Light Field Microscopy

Recording the highly diverse and dynamic activities in large populations of neurons in behaving animals is crucial for a better understanding of how the brain works.To meet this challenge,extensive efforts have been devoted to developing functional fluorescent indicators and optical imaging techniques to optically monitor neural activity.Indeed,optical imaging potentially has extremely high throughput due to its non-invasive access to large brain regions and capability to sample neurons at high density,but the readout speed,such as the scanning speed in two-photon scanning microscopy,is often limited by various practical considerations.Among different imaging methods,light field microscopy features a highly parallelized 3D fluorescence imaging scheme and therefore promises a novel and faster strategy for functional imaging of neural activity.Here,we briefly review the working principles of various types of light field microscopes and their recent developments and applications in neuroscience studies.We also discuss strategies and considerations of optimizing light field microscopy for different experimental purposes,with illustrative examples in imaging zebrafish and mouse brains.