Comparison of heating mechanisms of argon helicon plasma in different wave modes with and without blue core

In this work,we investigated the discharge characteristics and heating mechanisms of argon helicon plasma in different wave coupled modes with and without blue core.Spatially resolved spectroscopy and emission intensity of argon atom and ion lines were measured via local optical emission spectroscopy,and electron density was measured experimentally by an RFcompensated Langmuir probe.The relation between the emission intensity and the electron density was obtained and the wavenumbers of helicon and’Trivelpiece-Gould’(TG)waves were calculated by solving the dispersion relation in wave modes.The results show that at least two distinct wave coupled modes appear in argon helicon plasma at increasing RF power,i.e.blue core(or BC)mode with a significant bright core of blue lights and a normal wave(NW)mode without blue core.The emission intensity of atom line 750.5 nm(lArⅠ750.5nm)is related to the electron density and tends to be saturated in wave coupled modes due to the neutral depletion,while the intensity of ion line 480.6 nm(IArⅡ480.6nm)is a function of the electron density and temperature,and increases dramatically as the RF power is increased.Theoretical analysis shows that TG waves are strongly damped at the plasma edge in NW and/or BC modes,while helicon waves are the dominant mechanism of power deposition or central heating of electrons in both modes.The formation of BC column mainly depends on the enhanced central electron heating by helicon waves rather than TG waves since the excitation of TG waves would be suppressed in this special anti-resonance region.

Effect of neutral pressure on the blue core in Ar helicon plasma under an inhomogeneous magnetic field

The effect of neutral pressure on the blue core in Ar helicon plasma under an inhomogeneous magnetic field was investigated in this work.The neutral pressure was set to 0.08 Pa,0.36 Pa,and 0.68 Pa.A Nikon camera,intensified charge-coupled device(ICCD),optical emission spectrometer(OES),and Langmuir probe were used to diagnose the blue core in helicon plasma.Helicon plasma discharges experienced density jumps from the E mode,H mode to W mode before power just rose to 200 W.The plasma density increased and maintained a central peak with the increase of neutral pressure.However,the brightness of the blue core gradually decreased.It is demonstrated that the relative intensity of Ar II spectral lines and the ionization rate in the central area were reduced.Radial electron temperature profiles were flattened and became hollow as neutral pressure increased.It is demonstrated that increasing the neutral pressure weakened the central heating efficiency dominated by the helicon wave and strengthened the edge heating efficiency governed by the TG wave and skin effect.Therefore,the present experiment successfully reveals how the neutral pressure affects the heating mechanism of helicon plasma in an inhomogeneous magnetic field.

MdGSTF6,activated by MdMYB1,plays an essential role in anthocyanin accumulation in apple

Anthocyanins are biosynthesized on the cytosolic surface of the endoplasmic reticulum and then transported into the vacuole for storage.Glutathione S-transferases(GSTs)are considered to be responsible for the transport of anthocyanins into the vacuole.However,the regulatory mechanisms of GSTs in plants are still unclear.Here,we performed a genome-wide analysis and identified 69 GST genes in apple.The expression of MdGSTF6 was positively correlated with the anthocyanin content(r=0.949)during‘Yanfu 8’fruit development.The overexpression of MdGSTF6 in the Arabidopsis thaliana tt19 mutant resulted in seedlings of 35S::MdGSTF6-GFP/tt19 that could accumulate anthocyanin and rescue its phenotype,suggesting that MdGSTF6 was an anthocyanin transporter.The silencing of MdGSTF6 affected anthocyanin accumulation in apple fruit.Moreover,the knockdown of MdGSTF6 by RNA interference in cultured‘Gala’seedlings inhibited anthocyanin accumulation.The interaction experiments showed that MdMYB1 could bind directly to the MdGSTF6 promoter to transcriptionally activate its expression.Collectively,our results demonstrate that MdGSTF6 encodes an important GST transporter of anthocyanins in apple fruit and provide evidence for the associated regulatory mechanisms.Therefore,MdMYB1 can not only regulate anthocyanin synthesis,but also control the transport of anthocyanin in apples.This information may be useful for further clarifying the regulation of anthocyanin transport in apple.

Characteristics of inductively coupled plasma(ICP)and helicon plasma in a single-loop antenna

Large area uniform plasma sources,such as high-density magnetized inductively coupled plasma(ICP)and helicon plasma,have broad applications in industry.A comprehensive comparison of ICP and helicon plasma,excited by a single-loop antenna,is presented in this paper from the perspectives of mode transition,hysteresis behavior,and density distribution.The E-H mode transition in ICP and the E-H-W mode transition in helicon plasma are clearly observed in the experiments.Besides,the considerable variation of hysteresis behavior from inverse hysteresis to normal hysteresis by the influence of the magnetic field is explored.The bi-Maxwellian and Maxwellian electron energy distribution functions in each discharge are used to explain this phenomenon,which is essentially related to the transition from a nonlocal kinetic property to a local kinetic property of electrons.In addition,we notice that the plasma density,in the radial direction,is peaked in the center of the tube in ICP,but a complicated distribution is formed in helicon plasma.In the axial direction,the maximum plasma density is still in the center of the antenna in ICP,whereas the highest plasma density is located downstream,far away from the antenna,in helicon plasma.It is believed that the reflected electrons in the sheath and pre-sheath by the upper metallic endplate and downstream propagated helicon wave will be responsible for this plasma density profile in helicon plasma.Due to the constrained electron motion in the magnetic field,an extremely uniform density distribution will be obtained with an appropriate axial magnetic field in the wave discharge mode.

Region-of-interest micro-focus computed tomography based on an all-optical inverse Compton scattering source

Micro-focus computed tomography(CT),which allows the hyperfine structure within objects to be reconstructed,is a powerful nondestructive testing tool in many fields.However,current x-ray sources for micro-focus CT are typically limited by their relatively low photon energy and low flux.An all-optical inverse Compton scattering source(AOCS)based on laser wakefield acceleration can generate intense quasi-monoenergetic x/gamma-ray pulses in the kilo-to megaelectronvolt range with micrometer-level source size,and its potential application for micro-focus CT has become very attractive in recent years because of the rapid progress made in laser wakefield acceleration.Reported here is a successful experimental demonstration of high-fidelity micro-focus CT using an AOCS(∼70 keV)by imaging and reconstructing a test object with complex inner structures.A region-of-interest CT method is adopted to utilize the relatively small field of view of the AOCS to ensure high spatial resolution.This demonstration of AOCS-based region-of-interest micro-focus CT is a key step toward its application in the field of hyperfine nondestructive testing.

Comparison of double layer in argon helicon plasma and magnetized DC discharge plasma

We present in this paper the comparison of an electric double layer(DL)in argon helicon plasma and magnetized direct current(DC)discharge plasma.DL in high-density argon helicon plasma of 13.56 MHz RF discharge was investigated experimentally by a floating electrostatic probe and local optical emission spectroscopy(LOES).The DL characteristics at different operating parameters,including RF power(300-1500 W),tube diameter(8-60 mm),and external magnetic field(0-300 G),were measured.For comparison,DL in magnetized plasma channel of a DC discharge under different conditions was also measured experimentally.The results show that in both cases,DL appears in a divergent magnetic field where the magnetic field gradient is the largest and when the plasma density is sufficiently high.DL strength(or potential drop of DL)increases with the magnetic field in two different structures.It is suggested that the electric DL should be a common phenomenon in dense plasma under a gradient external magnetic field.DL in magnetized plasmas can be controlled properly by magnetic field structure and discharge mode(hence the plasma density).

Dynamics of plasma bullets by nanosecond pulsed micro-hollow cathode discharge within air

In this paper,the air plasma jet produced by micro-hollow cathode discharge(MHCD)is investigated.The discharge is powered by a positive nanosecond pulse high voltage supply.The waveforms of the discharge,the images of the jet,the evolution of the plasma bullet and the reactive species are obtained to analyze the characteristics of the MHCD plasma jet.It is found that the length of the plasma jet is almost proportional to the air flow rate of 2–6 slm.Two plasma bullets appear one after another during a single period of the voltage waveform,and both of the two plasma bullets are formed during the positive pulse voltage off.The propagation velocity of the two plasma bullets is on the order of several hundred m/s,which is approximate to that of the air flow.These results indicate that the gas flow has an important influence on the formation of this MHCD plasma jet.

CEPC Technical Design Report

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international partners.The complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs factory.In its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs bosons.Increasing the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of magnitude.This Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering aspects.Additionally,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection procedures.Construction is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 years.The commencement of experiments and data collection could potentially be initiated in the mid-2030s.

Gain-of-function mutant p53 in cancer progression and therapy

p53 is a key tumor suppressor,and loss of p53 function is frequently a prerequisite for cancer development.The p53 gene is the most frequently mutated gene in human cancers;p53 mutations occur in>50%of all human cancers and in almost every type of human cancers.Most of p53 mutations in cancers are missense mutations,which produce the full-length mutant p53(mutp53)protein with only one amino acid difference from wild-type p53 protein.In addition to loss of the tumor-suppressive function of wild-type p53,many mutp53 proteins acquire new oncogenic activities independently of wild-type p53 to promote cancer progression,termed gain-of-function(GOF).Mutp53 protein often accumulates to very high levels in cancer cells,which is critical for its GOF.Given the high mutation frequency of the p53 gene and the GOF activities of mutp53 in cancer,therapies targeting mutp53 have attracted great interest.Further understanding the mechanisms underlying mutp53 protein accumulation and GOF will help develop effective therapies treating human cancers containing mutp53.In this review,we summarize the recent advances in the studies on mutp53 regulation and GOF as well as therapies targeting mutp53 in human cancers.

Parallel-coupled linear-phase superconducting filter

A novel double coupling planar structure(a single microstrip line coupled with two resonators coincidental)is presented for the first time.Based on this structure,a six-pole parallel-coupled high-temperature superconducting bandpass filter with both linear phase response and quasi-elliptic function response is designed.The filter has a 40 MHz passband with a center frequency of 2,000 MHz.Its dimension is18.67 mm 9 25.96 mm.At 77 K,minimum insertion loss is0.26 dB in passband.The group delay variation is\3 ns over70%of the filter bandwidth.