期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Longan Aril Reverses H2O2 Cytotoxicity in PC12 Cells via RAS/MEK/ERK Signaling Pathway
1
作者 tianrong lei Yang CAO +4 位作者 Chang LI Jianghua ZHANG Honghe XIAO Cheng SONG Hongyan LI 《Medicinal Plant》 CAS 2021年第2期54-59,共6页
[Objectives]To explore the neuroprotective effects and mechanism of Longan Aril(LA)effective parts on PC12 cells injured by H2O2.[Methods]The neuroprotective effects of LA were evaluated by the cell viability,SOD and ... [Objectives]To explore the neuroprotective effects and mechanism of Longan Aril(LA)effective parts on PC12 cells injured by H2O2.[Methods]The neuroprotective effects of LA were evaluated by the cell viability,SOD and MDA content,apoptosis assay and relative protein expression of Aβand p-Tau.The neuroprotective mechanism of LA was studied by using metabolomics and network pharmacology,and the expressions of RAS/MEK/ERK signaling pathway-related proteins were detected by western blotting.[Results]LA could improve the cell survival rate and SOD content,and reduce apoptosis and expression of Aβand p-tau.Inhibition of RAS/MEK/ERK signaling pathway is a possible mechanism of LA neuroprotective effects.[Conclusions]LA has a neuroprotective effects in vitro and be likely to inhibit the process of AD by inhibition of RAS/MEK/ERK signalling pathway. 展开更多
关键词 Longan Aril(LA) RAS/MEK/ERK pathway Alzheimer's disease(AD) Neuroprotective effects
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部