In this study, the SiO2eCaOeP2O5 ternary component of bioactive glass particles were successfullysynthesized by sol-gel method, then the bioactive glass particles were pressed into tablets with drypressing molding tec...In this study, the SiO2eCaOeP2O5 ternary component of bioactive glass particles were successfullysynthesized by sol-gel method, then the bioactive glass particles were pressed into tablets with drypressing molding technology. The physicochemical structure, in-vitro bioactivity and biocompatibility ofBG tablets were characterized by various methods, such as XRD、SEM、FTIR, etc. The results showedthat the sol-gel bioactive glass particle was distinguished with its amorphous structure and micron-size.After being soaked in Tris-Hcl solution for 15 d, the bioactive glass tablets didn't collapse. Also, themineralization assay in vitro showed that the bioactive glass tablets had good capability of inducing theformation of hydroxycarbonate apatite (HCA) after being immersed in simulated body fluid (SBF). Inaddition, the cytotoxicity assay indicated that the osteoblast (MC3T3) grew well on the surface ofbioactive glass tablets. According to the above results, the bioactive glass tablets presented good mechanicalstrength, excellent apatite-forming activity and high biocompatibility, which demonstratedtheir potential applications in the field of bone defect repairing.展开更多
基金This work was supported by the Joint Funds of the National Natural Science Foundation of China(Grant No.U1501245)the Fundamental Research Funds for the Central Universities(2015ZP020)+1 种基金the National Natural Science Foundation of China(Grant No.51672088)the science and technology innovation team project of Foshan(No.2015IT100062).
文摘In this study, the SiO2eCaOeP2O5 ternary component of bioactive glass particles were successfullysynthesized by sol-gel method, then the bioactive glass particles were pressed into tablets with drypressing molding technology. The physicochemical structure, in-vitro bioactivity and biocompatibility ofBG tablets were characterized by various methods, such as XRD、SEM、FTIR, etc. The results showedthat the sol-gel bioactive glass particle was distinguished with its amorphous structure and micron-size.After being soaked in Tris-Hcl solution for 15 d, the bioactive glass tablets didn't collapse. Also, themineralization assay in vitro showed that the bioactive glass tablets had good capability of inducing theformation of hydroxycarbonate apatite (HCA) after being immersed in simulated body fluid (SBF). Inaddition, the cytotoxicity assay indicated that the osteoblast (MC3T3) grew well on the surface ofbioactive glass tablets. According to the above results, the bioactive glass tablets presented good mechanicalstrength, excellent apatite-forming activity and high biocompatibility, which demonstratedtheir potential applications in the field of bone defect repairing.
